869288-64-2 | PF-573228

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$34.00	$24.00
5mg	99%	in stock	$108.00	$76.00
50mg	99%	in stock	$289.00	$203.00
100mg	99%	in stock	$433.00	$303.00

Description

• Catalog Number: AC13997
• Chemical Name: PF-573228
• CAS Number: 869288-64-2
• Molecular Formula: C22H20F3N5O3S
• Molecular Weight: 491.4861
• MDL Number: MFCD11519967
• SMILES: O=C1CCc2c(N1)ccc(c2)Nc1ncc(c(n1)NCc1cccc(c1)S(=O)(=O)C)C(F)(F)F

Computed Properties

• Complexity: 822
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6
• XLogP3: 3.2

Literature

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  Toxicology 20170601

• Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells.

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• Identification of potent Yes1 kinase inhibitors using a library screening approach.

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• Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228.

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• Effect of focal adhesion kinase on the regulation of realignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch.

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• Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells.

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• Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

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• DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.

  Oncogene 20101202

• Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes.

  Journal of neurochemistry 20101001

• Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts.

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• Characterization of a novel focal adhesion kinase inhibitor in human platelets.

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