87-41-2 | Phthalide

Packsize	Purity	Availability	Price	Discounted Price
25g	98%	in stock	$9.00	$6.00
100g	98%	in stock	$12.00	$8.00

Description

• Catalog Number: AB78345
• Chemical Name: Phthalide
• CAS Number: 87-41-2
• Molecular Formula: C8H6O2
• Molecular Weight: 134.13204
• MDL Number: MFCD00005906
• SMILES: O=C1OCc2c1cccc2
• NSC Number: 1469

Computed Properties

• Complexity: 153
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 0.8

Literature

• Total synthesis of 7',8'-dihydroaigialospirol.

  Organic letters 20121005

• Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists.

  Bioorganic & medicinal chemistry 20120815

• C(Ar)-H···O hydrogen bonds in substituted isobenzofuranone derivatives: geometric, topological, and NMR characterization.

  The journal of physical chemistry. A 20120726

• Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in Chuanxiong Rhizoma in rats.

  Current drug metabolism 20120601

• Phthalide and isocoumarin derivatives produced by an Acremonium sp. isolated from a mangrove Rhizophora apiculata.

  Journal of natural products 20120525

• Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones.

  Chemical communications (Cambridge, England) 20120516

• CN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: a facile entry to 3-substituted chiral phthalides.

  Organic & biomolecular chemistry 20120514

• Nucleophile- or light-induced synthesis of 3-substituted phthalides from 2-formylarylketones.

  Organic letters 20120504

• Simultaneous determination of nine related substances in p-phthalic acid residue by RP-HPLC.

  Journal of chromatographic science 20120501

• Copper(I) mediated facile synthesis of potent tubulin polymerization inhibitor, 9-amino-α-noscapine from natural α-noscapine.

  Bioorganic & medicinal chemistry letters 20120415

• Stereoselective synthesis of hydroxy stilbenoids and styrenes by atom-efficient olefination with thiophthalides.

  Organic & biomolecular chemistry 20120414

• A novel antioxidant isobenzofuranone derivative from fungus Cephalosporium sp.AL031.

  Molecules (Basel, Switzerland) 20120405

• Highly stereoselective chemoenzymatic synthesis of the 3H-isobenzofuran skeleton. Access to enantiopure 3-methylphthalides.

  Organic letters 20120316

• Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways.

  Archives of pharmacal research 20120301

• Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones.

  Bioorganic & medicinal chemistry 20120201

• Two phthalide dimers from the radix of Angelica sinensis.

  Natural product research 20120101

• Ligustilide: a novel TRPA1 modulator.

  Pflugers Archiv : European journal of physiology 20111201

• Two new compounds from an endophytic fungus Pestalotiopsis heterocornis.

  Journal of Asian natural products research 20111201

• The atmospheric photolysis of o-tolualdehyde.

  Environmental science & technology 20111115

• Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae.

  The Journal of antibiotics 20111101

• Ligusticum chuanxiong Hort: a review of chemistry and pharmacology.

  Pharmaceutical biology 20111101

• Synthesis of biarylketones and phthalides from organoboronic acids and aldehydes catalyzed by cobalt complexes.

  Chemical communications (Cambridge, England) 20111007

• Ruthenium-catalyzed oxidative C-H bond alkenylations in water: expedient synthesis of annulated lactones.

  Organic letters 20110819

• Adulticidal activity of phthalides identified in Cnidium officinale rhizome to B- and Q-biotypes of Bemisia tabaci.

  Journal of agricultural and food chemistry 20110810

• Phthalides and other constituents from Ligusticum porteri; sedative and spasmolytic activities of some natural products and derivatives.

  Natural product research 20110801

• Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions.

  Bioorganic & medicinal chemistry letters 20110615

• Benzannulation for the regiodefined synthesis of 2-alkyl/aryl-1-naphthols: total synthesis of arnottin I.

  The Journal of organic chemistry 20110506

• Chemical composition of the essential oil from kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice.

  Clinics (Sao Paulo, Brazil) 20110501

• Correlative analysis of metabolite profiling of Danggui Buxue Tang in rat biological fluids by rapid resolution LC-TOF/MS.

  Journal of pharmaceutical and biomedical analysis 20110428

• Metabolic profiling of GuanXin II prescription based on metabolic fingerprinting and chemical analysis.

  Journal of pharmaceutical and biomedical analysis 20110325

• Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids from Indonesian, Tahitian and Japanese liverworts.

  Natural product communications 20110301

• Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.

  Journal of natural products 20110128

• The use of endophytes to obtain bioactive compounds and their application in biotransformation process.

  Biotechnology research international 20110101

• Identification of the major constituents in Xuebijing injection by HPLC-ESI-MS.

  Phytochemical analysis : PCA 20110101

• Antimicrobial activities of hexane extract and decussatin from stembark extract of Ficus congensis.

  International journal of molecular sciences 20110101

• Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway.

  Frontiers in microbiology 20110101

• Bioactivities of major constituents isolated from Angelica sinensis (Danggui).

  Chinese medicine 20110101

• Polyphasic analysis of intraspecific diversity in Epicoccum nigrum warrants reclassification into separate species.

  PloS one 20110101

• Antibacterial activity of new dibenzoxepinone oximes with fluorine and trifluoromethyl group substituents.

  International journal of molecular sciences 20110101

• Synthesis and Antimicrobial Evaluation of Dibenzo[b,e]oxepin-11(6H)-one O-Benzoyloxime Derivatives.

  Scientia pharmaceutica 20110101

• Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp.

  Beilstein journal of organic chemistry 20110101

• A practical total synthesis of (+)-spirolaxine methyl ether.

  The Journal of organic chemistry 20101203

• New isocourmarin and phthalide derivatives from the rhizomes of Matteuccia orientalis.

  Chemical & pharmaceutical bulletin 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.

  The Journal of organic chemistry 20100903

• Synthesis of demethylated nidulol via an intramolecular Michael reaction.

  Natural product research 20100801

• 3-Acetyl-benzoic acid.

  Acta crystallographica. Section E, Structure reports online 20100701

• Rhodium-catalyzed cascade reaction: aryl addition/intramolecular esterification to access 3-aryl and 3-alkenyl phthalides.

  Angewandte Chemie (International ed. in English) 20100510

• Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides.

  Chemical communications (Cambridge, England) 20100507

• Pesticide residues in coastal waters affected by rice paddy effluents temporarily stored in a wastewater reservoir in southern Japan.

  Archives of environmental contamination and toxicology 20100201

• Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide.

  The Journal of organic chemistry 20100115

• Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.

  Molecules (Basel, Switzerland) 20100115

• Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity.

  Biological & pharmaceutical bulletin 20100101

• Efficient synthesis of 3-arylphthalides using palladium-catalyzed arylation of aldehydes with organoboronic acids.

  The Journal of organic chemistry 20091204

• Evaluation of the in vivo antimalarial activity of ethanolic leaf and stembark extracts of Anthocleista djalonensis.

  Indian journal of pharmacology 20091201

• Phthalides by rhodium-catalyzed ketone hydroacylation.

  Journal of the American Chemical Society 20091104

• Catalytic enantioselective synthesis of chiral phthalides by efficient reductive cyclization of 2-acylarylcarboxylates under aqueous transfer hydrogenation conditions.

  Organic letters 20091015

• 3,3'-Oxybi[isobenzofuran-1(3H)-one].

  Acta crystallographica. Section E, Structure reports online 20091001

• Two new compounds from the roots of Ligusticum chuanxiong.

  Journal of Asian natural products research 20090901

• A novel compound from celery seed with a bactericidal effect against Helicobacter pylori.

  The Journal of pharmacy and pharmacology 20090801

• Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20090701

• Biomimetic studies towards the cardinalins: synthesis of (+)-ventiloquinone L and an unusual dimerisation.

  Organic & biomolecular chemistry 20090621

• Daily variation of pesticides in surface water of a small river flowing through paddy field area.

  Bulletin of environmental contamination and toxicology 20090601

• Preparative isolation and purification of isobenzofuranone derivatives and saponins from seeds of Nigella glandulifera Freyn by high-speed counter-current chromatography combined with gel filtration.

  Journal of chromatography. A 20090508

• 2-(3-Oxo-1,3-dihydro-isobenzofuran-1-yl)-phthalazin-1(2H)-one.

  Acta crystallographica. Section E, Structure reports online 20090501

• Occurence and bioactivities of funicone-related compounds.

  International journal of molecular sciences 20090401

• New phthalide glycosides from Helichrysum arenarium (L.) Moench.

  Journal of Asian natural products research 20090101

• Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii.

  Journal of AOAC International 20090101

• New antitumour fungal metabolites from Alternaria porri.

  Natural product research 20090101

• Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes.

  Parasitology research 20081201

• [Analysis of principal composition of ethyl acetate part in Huangqi Danggui decoction by HPLC-ESI-TOF-MS].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

• Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.

  Journal of ethnopharmacology 20081030

• Decrease of 4,5,6,7-tetrachlorophthalide in paddy field soil after aerial application.

  Bulletin of environmental contamination and toxicology 20081001

• Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.

  Journal of natural products 20081001

• Dynamic nature of the ligustilide complex.

  Journal of natural products 20080901

• 3-(5,6,7,8-Tetra-hydro-2-naphth-yl)iso-benzofuran-1(3H)-one.

  Acta crystallographica. Section E, Structure reports online 20080901

• Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20080801

• Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015.

  Bioorganic & medicinal chemistry 20080601

• Variation of 4,5,6,7-tetrachlorophthalide in water after aerial application to rice cultivation area.

  Bulletin of environmental contamination and toxicology 20080501

• 3-(4-Methyl-piperazin-1-yl)isobenzofuran-1(3H)-one.

  Acta crystallographica. Section E, Structure reports online 20080501

• 3-(2-Hydr-oxy-5-methyl-anilino)isobenzo-furan-1(3H)-one.

  Acta crystallographica. Section E, Structure reports online 20080501

• High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of phosphatidylinositol-specific phospholipase C.

  Analytical biochemistry 20080415

• 2-(3-Oxo-1,3-dihydro-isobenzofuran-1-ylamino)benzoic acid.

  Acta crystallographica. Section E, Structure reports online 20080401

• 3-(2-Chloro-anilino)isobenzofuran-1(3H)-one.

  Acta crystallographica. Section E, Structure reports online 20080401

• 3-(2,4-Dichloro-anilino)iso-benzo-furan-1(3H)-one.

  Acta crystallographica. Section E, Structure reports online 20080401

• [GC-MS analysis of essential oil from rhizomes of Ligusticum chuanxiong cultivated in GAP base for Chinese medicinal materials of China].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

• Flavor enhancement of chicken broth from boiled celery constituents.

  Journal of agricultural and food chemistry 20080123

• Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats.

  Pharmacology, biochemistry, and behavior 20080101

• Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales.

  Planta medica 20080101

• Chemical markers for the quality control of herbal medicines: an overview.

  Chinese medicine 20080101

• Reductive dechlorination of chloroethenes by Dehalococcoides-containing cultures enriched from a polychlorinated-dioxin-contaminated microcosm.

  The ISME journal 20071001

• Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone.

  Bioorganic & medicinal chemistry letters 20070915

• Importance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level.

  ChemMedChem 20070701

• Direct access to 1,4-dihydroxyanthraquinones: the Hauser annulation reexamined with p-quinones.

  The Journal of organic chemistry 20070622

• Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells.

  Planta medica 20070601

• The structural diversity of phthalides from the Apiaceae.

  Journal of natural products 20070501

• Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry.

  Planta medica 20070401

• Rhodium-catalyzed asymmetric one-pot transesterification and [2 + 2 + 2] cycloaddition leading to enantioenriched 3,3-disubstituted phthalides.

  Organic letters 20070329

• Highly efficient cyclization of o-iodobenzoates with aldehydes catalyzed by cobalt bidentate phosphine complexes: a novel entry to chiral phthalides.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• An alkyne strategy for the asymmetric synthesis of natural products: application to (+)-spirolaxine methyl ether.

  Angewandte Chemie (International ed. in English) 20070101

• Absolute configuration of sporotricale and structure of 6-hydroxysporotricale.

  Journal of natural products 20061201

• Regiocontrolled intramolecular cyclizations of carboxylic acids to carbon-carbon triple bonds promoted by acid or base catalyst.

  Organic letters 20061123

• The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo.

  Journal of neurochemistry 20061101

• [High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis].

  Yao xue xue bao = Acta pharmaceutica Sinica 20061101

• Runoff of aerially applied phthalide from paddy fields.

  Bulletin of environmental contamination and toxicology 20061001

• Kinetics and products of photolysis and reaction with OH radicals of a series of aromatic carbonyl compounds.

  Environmental science & technology 20060901

• Synthesis of (+)-spirolaxine methyl ether.

  The Journal of organic chemistry 20060804

• Uptake and UV-photooxidation of gas-phase PAHs on the surface of atmospheric water films. 1. Naphthalene.

  The journal of physical chemistry. A 20060727

• Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines.

  European journal of medicinal chemistry 20060601

• Two new phthalides from Ligusticum chuanxiong.

  Planta medica 20060601

• Determination of volatile flavor components in danggui cultivars by solvent free injection and hydrodistillation followed by gas chromatographic-mass spectrometric analysis.

  Journal of chromatography. A 20060526

• Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors.

  Bioorganic & medicinal chemistry letters 20060401

• Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery.

  Bioscience, biotechnology, and biochemistry 20060401

• Total synthesis and biological evaluation of 22-hydroxyacuminatine.

  Journal of medicinal chemistry 20060223

• Simultaneous qualitative and quantitative analyses of the major constituents in the rhizome of Ligusticum Chuanxiong using HPLC-DAD-MS.

  Chemical & pharmaceutical bulletin 20060201

• Sulfated mesoporous alumina: a highly effective solid strong base catalyst for the Tishchenko reaction in supercritical carbon dioxide.

  The journal of physical chemistry. B 20060126

• Total syntheses of oxygenated brazanquinones via regioselective homologous anionic Fries rearrangement of benzylic O-carbamates.

  Beilstein journal of organic chemistry 20060101

• GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.

  Phytochemical analysis : PCA 20060101

• A brief and convergent synthetic route to defucogilvocarcin M chromophore: the formal synthesis of WS-5995 A and C.

  The Journal of organic chemistry 20051028

• Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation.

  Planta medica 20050901

• Anxiolytic effects of benzalphthalides.

  Bioorganic & medicinal chemistry letters 20050801

• Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster.

  Journal of agricultural and food chemistry 20050713

• Synthesis of enantiopure phthalides including 3-butylphthalide, a fragrance component of celery oil, and determination of their absolute configurations.

  Chirality 20050505

• [Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050301

• Enantiomerical excess determination, purification and biological evaluation of (3S) and (3R) alpha,beta-butenolide analogues of isobenzofuranone.

  Bioorganic & medicinal chemistry letters 20050201

• [New dimeric phthalide derivative from Angelica sinensis].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050201

• HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong.

  Molecular diversity 20050101

• Efficient synthesis of isobenzofuran-1(3H)-ones (phthalides) and selected biological evaluations.

  Arzneimittel-Forschung 20050101

• A phthalide with in vitro growth inhibitory activity from an oidiodendron strain.

  Journal of natural products 20041201

• Insecticidal effect of phthalides and furanocoumarins from Angelica acutiloba against Drosophila melanogaster.

  Journal of agricultural and food chemistry 20040714

• Synthesis of phthalide derivatives using nickel-catalyzed cyclization of o-haloesters with aldehydes.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20040621

• Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C.

  Bioorganic & medicinal chemistry letters 20040607

• Evaluation of series of isobenzofuranone dimers as PKCalpha ligands: implication for the distance between the two ligand binding sites.

  Bioorganic & medicinal chemistry letters 20040607

• Polar constituents of celery seed.

  Phytochemistry 20031101

• A new regiospecific preparation of xanthones.

  Organic letters 20031002

• Synthesis and absolute configuration of (-)-3-butyl-7-hydroxyphthalide, a cytotoxic metabolite of Penicillium vulpinum.

  Bioscience, biotechnology, and biochemistry 20031001

• Characterization of phthalides in Ligusticum chuanxiong by liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometry.

  Journal of chromatographic science 20030901

• A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp.

  Planta medica 20030901

• Total synthesis of (+/-)-O-methyl PD 116740.

  Organic letters 20020627

• Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities.

  Phytochemistry 20020501

• Application of microgels as polymer supports for organic synthesis: preparation of a small phthalide library, a scavenger, and a borohydride reagent.

  Journal of combinatorial chemistry 20020101

• Efficient heterogeneous catalytic intramolecular Tishchenko reaction of o-phthalaldehyde to phthalide with alkaline earth oxides.

  Chemical communications (Cambridge, England) 20011207

• A new alternative synthesis of 5-cyanophthalide, a versatile intermediate in the preparation of the antidepressant drug citalopram.

  Farmaco (Societa chimica italiana : 1989) 20010901

• Characterization of an unknown component in Noscapine using liquid chromatography-mass spectrometry and proton nuclear magnetic resonance spectroscopy.

  Journal of chromatography. A 20010824

• Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis.

  Structure (London, England : 1993) 20010110

• Solid-phase directed ortho-lithiation and the preparation of a phthalide library.

  Journal of combinatorial chemistry 20010101

• Sedanolide, a natural phthalide from celery seed oil: effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines.

  In vitro & molecular toxicology 20010101