870653-45-5 | 4-(4-Phenoxybutoxy)-7h-furo[3,2-g]chromen-7-one

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$52.00	$36.00
5mg	95%	in stock	$116.00	$81.00
50mg	95%	in stock	$318.00	$222.00

Description

• Catalog Number: AC11532
• Chemical Name: 4-(4-Phenoxybutoxy)-7h-furo[3,2-g]chromen-7-one
• CAS Number: 870653-45-5
• Molecular Formula: C21H18O5
• Molecular Weight: 350.3646
• MDL Number: MFCD11114059
• SMILES: O=c1ccc2c(o1)cc1c(c2OCCCCOc2ccccc2)cco1

Computed Properties

• Complexity: 499
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• XLogP3: 4.7

Literature

• Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate.

  Bioorganic & medicinal chemistry letters 20121201

• Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues.

  American journal of physiology. Endocrinology and metabolism 20110801

• Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2.

  Bioorganic & medicinal chemistry letters 20101201

• 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3.

  European journal of medicinal chemistry 20090501

• Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques.

  Experimental biology and medicine (Maywood, N.J.) 20071101

• Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.

  Molecular pharmacology 20051101