873-75-6 | 4-Bromobenzyl alcohol

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$5.00	$4.00
25g	98%	in stock	$8.00	$6.00
100g	98%	in stock	$18.00	$13.00
500g	98%	in stock	$89.00	$63.00

Description

• Catalog Number: AB66973
• Chemical Name: 4-Bromobenzyl alcohol
• CAS Number: 873-75-6
• Molecular Formula: C7H7BrO
• Molecular Weight: 187.0339
• MDL Number: MFCD00004650
• SMILES: OCc1ccc(cc1)Br

Computed Properties

• Complexity: 77
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2

Upstream Synthesis Route

(4-Bromophenyl)methanol, also known as p-bromobenzyl alcohol, is a versatile chemical compound commonly used in organic synthesis for its unique reactivity and functional group properties. Due to its bromine substituent and hydroxyl group, (4-Bromophenyl)methanol serves as a valuable building block in the preparation of various pharmaceuticals, agrochemicals, and fine chemicals.In chemical synthesis, (4-Bromophenyl)methanol can undergo a variety of reactions to introduce new functional groups or modify existing ones. One of its key applications is as a precursor in the synthesis of aryl ethers, which are important structural motifs found in numerous biologically active compounds. By reacting (4-Bromophenyl)methanol with suitable reagents, researchers can efficiently incorporate the p-bromobenzyl alcohol moiety into target molecules, enabling the creation of diverse chemical structures with enhanced pharmacological properties.Furthermore, (4-Bromophenyl)methanol can participate in transition metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura coupling, to form biaryl compounds. These biaryl derivatives are essential components in the development of pharmaceuticals, materials, and natural product synthesis. Additionally, the hydroxyl group in (4-Bromophenyl)methanol can serve as a handle for further functionalization through esterification, etherification, or oxidation reactions, expanding its synthetic utility in organic chemistry.Overall, the strategic incorporation of (4-Bromophenyl)methanol in chemical synthesis offers chemists a powerful tool for designing and constructing complex molecules with specific functionalities, making it a valuable reagent in medicinal and materials chemistry research.

Literature

• Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.

  Journal of medicinal chemistry 20050630

• Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

  Journal of medicinal chemistry 20040729