873837-23-1 | BMS-599626 Hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$32.00	$22.00
5mg	99%	in stock	$78.00	$54.00
10mg	99%	in stock	$116.00	$81.00
25mg	99%	in stock	$196.00	$137.00
50mg	99%	in stock	$323.00	$226.00
100mg	99%	in stock	$510.00	$357.00

Description

• Catalog Number: AH85244
• Chemical Name: BMS-599626 Hydrochloride
• CAS Number: 873837-23-1
• Molecular Formula: C27H28ClFN8O3
• Molecular Weight: 567.0144232
• MDL Number: MFCD12407406
• SMILES: O=C(Nc1cn2c(c1C)c(ncn2)Nc1ccc2c(c1)cnn2Cc1cccc(c1)F)OC[C@@H]1COCCN1.Cl

Computed Properties

• Complexity: 828
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 40
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 8

Literature

• Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors.

  Annals of oncology : official journal of the European Society for Medical Oncology 20120201

• AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo.

  Investigational new drugs 20110801

• Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

  Journal of medicinal chemistry 20091112