874-14-6 | 1,3-Dimethyluracil

Packsize	Purity	Availability	Price	Discounted Price
10g	98%	in stock	$13.00	$9.00
25g	98%	in stock	$17.00	$12.00
500g	98%	in stock	$299.00	$209.00

Description

• Catalog Number: AB57356
• Chemical Name: 1,3-Dimethyluracil
• CAS Number: 874-14-6
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.1399
• MDL Number: MFCD00038065
• SMILES: Cn1ccc(=O)n(c1=O)C
• NSC Number: 401858

Computed Properties

• Complexity: 210
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• XLogP3: -0.5

Upstream Synthesis Route

1,3-Dimethyluracil, also known as thymine, plays a crucial role in chemical synthesis as a versatile building block in organic chemistry. This compound is widely used in the pharmaceutical industry as a precursor for the synthesis of various drugs and bioactive molecules. In particular, 1,3-Dimethyluracil is utilized in the production of antiviral and anticancer agents due to its structural properties that enable the formation of important pharmacophores.Additionally, 1,3-Dimethyluracil serves as a key intermediate in the synthesis of nucleoside analogs, which are utilized in antiviral and antitumor treatments. Its unique molecular structure allows for diverse functionalization, making it a valuable tool in the creation of novel compounds with enhanced biological activity. Chemists leverage the synthetic versatility of 1,3-Dimethyluracil to design and develop new pharmaceuticals with improved efficacy and specificity.Furthermore, the application of 1,3-Dimethyluracil extends to the field of materials science, where it is used in the production of specialized polymers and composites. The reactivity of this compound enables the modification of polymer matrices to impart desired properties such as increased strength, thermal stability, and chemical resistance. By incorporating 1,3-Dimethyluracil into advanced materials, researchers can tailor their characteristics for specific industrial applications, ranging from coatings to electronics.In summary, 1,3-Dimethyluracil serves as a versatile and essential component in chemical synthesis, offering a wide range of applications in pharmaceuticals, materials science, and beyond. Its role as a foundational building block underscores its significance in advancing innovation and discovery in the realm of organic chemistry.

Literature

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  The journal of physical chemistry. A 20121004

• Ionization of dimethyluracil dimers leads to facile proton transfer in the absence of hydrogen bonds.

  Nature chemistry 20120318

• Heavy atom effects in the Paternò-Büchi reaction of pyrimidine derivatives with 4,4'-disubstituted benzophenones.

  Beilstein journal of organic chemistry 20110101

• Ab initio investigation of the methylation and hydration effects on the electronic spectra of uracil and thymine.

  Physical chemistry chemical physics : PCCP 20100521

• Zooming into pi-stacked manifolds of nucleobases: ionized states of dimethylated uracil dimers.

  The journal of physical chemistry. A 20100204

• Uracil and thymine reactivity in the gas phase: the S(N)2 reaction and implications for electron delocalization in leaving groups.

  Journal of the American Chemical Society 20091230

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  The journal of physical chemistry. A 20081127

• Probing noncovalent interactions in biomolecular crystals with terahertz spectroscopy.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20080314

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  Indian journal of biochemistry & biophysics 20051201

• [Raman spectroscopy study of 1,3-dimethyluracil and its ab initio (DFT) calculation].

  Guang pu xue yu guang pu fen xi = Guang pu 20041201

• Molecularly imprinted copolymer membranes functionalized by phase inversion imprinting for uracil recognition and permselective binding.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040505

• Model studies of the (6-4) photoproduct photoreactivation: synthesis and photosensitized splitting of uracil oxetane adducts.

  Bioorganic chemistry 20031001

• Equilibrium of formation of the 6-carbanion of UMP, a potential intermediate in the action of OMP decarboxylase.

  Journal of the American Chemical Society 20021127

• Photoinduced electron transfer cleavage of oxetane adducts of uracil and cytosine.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20020901

• The acidity of uracil and uracil analogs in the gas phase: four surprisingly acidic sites and biological implications.

  Journal of the American Society for Mass Spectrometry 20020801

• Fenton chemistry of 1,3-dimethyluracil.

  Journal of the American Chemical Society 20010919