89-25-8 | 3-Methyl-1-phenyl-2-pyrazolin-5-one

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$8.00	$5.00
1g	98%	in stock	$15.00	$10.00
25g	98%	in stock	$16.00	$11.00
100g	98%	in stock	$21.00	$15.00
500g	98%	in stock	$46.00	$32.00

Description

• Catalog Number: AD83310
• Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one
• CAS Number: 89-25-8
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.1992
• MDL Number: MFCD00003138
• SMILES: O=C1CC(=NN1c1ccccc1)C

Computed Properties

• Complexity: 241
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1.3

Literature

• Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.

  The Lancet. Neurology 20170701

• Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma.

  Cell death & disease 20170701

• Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease.

  Neuropharmacology 20160901

• Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability.

  Molecular neurobiology 20160501

• Edaravone attenuates brain damage in rats after acute CO poisoning through inhibiting apoptosis and oxidative stress.

  Environmental toxicology 20160301

• Ginsenoside Rd attenuates Aβ25-35-induced oxidative stress and apoptosis in primary cultured hippocampal neurons.

  Chemico-biological interactions 20150905

• Change in soluble epoxide hydrolase (sEH) during cisplatin-induced acute renal failure in mice.

  The Journal of toxicological sciences 20150801

• A novel pyrazolone-based derivative induces apoptosis in human esophageal cells via reactive oxygen species (ROS) generation and caspase-dependent mitochondria-mediated pathway.

  Chemico-biological interactions 20150425

• Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits.

  Proceedings of the National Academy of Sciences of the United States of America 20150421

• Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse.

  PloS one 20150101

• Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia.

  Placenta 20140701

• Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice.

  Pharmacognosy magazine 20140101

• Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation.

  BMC neuroscience 20130101

• Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke.

  Biomedical reports 20130101

• Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20121101

• Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD.

  The International journal of neuroscience 20121101

• Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model.

  Neuroscience 20121025

• Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant.

  Experimental and molecular pathology 20121001

• Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat.

  Molecular and cellular biochemistry 20121001

• Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C.

  The Journal of infectious diseases 20121001

• Mass spectrometric O-glycan analysis after combined O-glycan release by beta-elimination and 1-phenyl-3-methyl-5-pyrazolone labeling.

  Biochimica et biophysica acta 20120901

• Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy.

  Journal of cellular and molecular medicine 20120901

• Perfluorocarbon-facilitated CNS oxygen toxicity in rats: reversal by edaravone.

  Brain research 20120830

• Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one.

  Journal of medicinal chemistry 20120823

• A hypothesis: Edaravone exert cardioprotection partly via modulation of adiponectin.

  Medical hypotheses 20120801

• Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat.

  Molecular and cellular biochemistry 20120801

• Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model.

  World journal of gastroenterology 20120721

• A somatostatin analogue, octreotide, ameliorates intestinal ischemia-reperfusion injury through the early induction of heme oxygenase-1.

  The Journal of surgical research 20120615

• Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats.

  Journal of vascular surgery 20120601

• The effect of edaravone on ischemia-reperfusion injury in rat ovary.

  European journal of obstetrics, gynecology, and reproductive biology 20120601

• Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601

• Phase I clinical study of edaravone in healthy Chinese volunteers: safety and pharmacokinetics of single or multiple intravenous infusions.

  Drugs in R&D 20120601

• Discharge of solubilized and Dectin-1-reactive β-glucan from macrophage cells phagocytizing insoluble β-glucan particles: involvement of reactive oxygen species (ROS)-driven degradation.

  Biochemical and biophysical research communications 20120504

• The predominance of type I oligosaccharides is a feature specific to human breast milk.

  Advances in nutrition (Bethesda, Md.) 20120501

• [Neuroprotective effects of combined pretreatment with edaravone and propofol on neonatal rat cerebral cortical neurons with ischemia/reperfusion injury in vitro].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20120501

• What is the role of free radical scavengers in acute stroke?

  JPMA. The Journal of the Pakistan Medical Association 20120501

• Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform.

  Drug metabolism and disposition: the biological fate of chemicals 20120401

• Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary study.

  Journal of the neurological sciences 20120215

• Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain.

  Brain research 20120203

• Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20120201

• Combination of reactive oxygen species and tissue-type plasminogen activator enhances the induction of gelatinase B in brain endothelial cells.

  The International journal of neuroscience 20120201

• A novel flow-injection analysis system for evaluation of antioxidants by using sodium dichloroisocyanurate as a source of hypochlorite anion.

  Drug discoveries & therapeutics 20120201

• On the outstanding antioxidant capacity of edaravone derivatives through single electron transfer reactions.

  The journal of physical chemistry. B 20120126

• Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs.

  Bioorganic & medicinal chemistry 20120115

• Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury.

  Neuroscience 20120110

• Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils.

  Neuroscience letters 20120106

• Effect of edaravone on Aβ1-40 induced enhancement of voltage-gated calcium channel current.

  CNS neuroscience & therapeutics 20120101

• Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.

  Journal of pharmacological sciences 20120101

• Density functional theory (DFT) study of edaravone derivatives as antioxidants.

  International journal of molecular sciences 20120101

• Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina.

  Investigative ophthalmology & visual science 20111228

• Edaravone for acute ischaemic stroke.

  The Cochrane database of systematic reviews 20111207

• Beyond neurological disease: new targets for edaravone (Review).

  International journal of molecular medicine 20111201

• Optimization of monosaccharide determination using anthranilic acid and 1-phenyl-3-methyl-5-pyrazolone for gastropod analysis.

  Analytical biochemistry 20111101

• Relative quantitation of glycans using stable isotopic labels 1-(d0/d5) phenyl-3-methyl-5-pyrazolone by mass spectrometry.

  Analytical biochemistry 20111101

• One-pot nonreductive O-glycan release and labeling with 1-phenyl-3-methyl-5-pyrazolone followed by ESI-MS analysis.

  Proteomics 20111101

• [Therapeutic time window for ischemic stroke].

  Rinsho shinkeigaku = Clinical neurology 20111101

• Acquired platinum resistance enhances tumour angiogenesis through angiotensin II type 1 receptor in bladder cancer.

  British journal of cancer 20111025

• The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis.

  Arthritis and rheumatism 20111001

• Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone.

  Developmental neuroscience 20111001

• Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.

  Journal of neurotrauma 20111001

• New method for absolute spinal cord ischemia protection in rabbits.

  Journal of vascular surgery 20111001

• Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.

  Investigative ophthalmology & visual science 20110921

• Singlet oxygen is essential for neutrophil extracellular trap formation.

  Biochemical and biophysical research communications 20110916

• Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110901

• Ionization energies, proton affinities, and pKa values of a large series of edaravone derivatives: implication for their free radical scavenging activity.

  The journal of physical chemistry. B 20110901

• Comparison of polysaccharides from different Dendrobium using saccharide mapping.

  Journal of pharmaceutical and biomedical analysis 20110715

• Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice.

  Naunyn-Schmiedeberg's archives of pharmacology 20110701

• In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice.

  Brain research 20110623

• New treatment of free-radical scavenger in adrenoleukodystrophy.

  Journal of clinical pharmacy and therapeutics 20110601

• Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat.

  The journal of sexual medicine 20110601

• Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in Wistar rat brains.

  Neuroscience 20110519

• Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment.

  Investigative ophthalmology & visual science 20110501

• C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation.

  Arteriosclerosis, thrombosis, and vascular biology 20110501

• Translational stroke research of the combination of thrombolysis and antioxidant therapy.

  Stroke 20110501

• [Future neuroprotective strategies in the post-thrombolysis era--neurovascular unit protection and vascular endothelial protection].

  Rinsho shinkeigaku = Clinical neurology 20110501

• Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity.

  The Journal of biological chemistry 20110415

• Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.

  Neuroscience research 20110401

• Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats.

  The Journal of pharmacy and pharmacology 20110401

• Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis.

  The Tohoku journal of experimental medicine 20110401

• [Stimulative effect of edaravone on growth of neuronal stem cells and precursor cells following lesioning of hippocampal dentate gyrus].

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20110401

• Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger.

  Brain research 20110325

• [Effects of edaravone on glial fibrillary acidic protein and interleukin-lβ expression and neuronal apoptosis in juvenile rat hippocampus after status convulsion].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110301

• [Separation of 1-phenyl-3-methyl-5-pyrazolone derivatives of traditional Chinese medicine oligosaccharides by capillary zone electrophoresis].

  Se pu = Chinese journal of chromatography 20110301

• Edaravone for acute intracerebral haemorrhage.

  The Cochrane database of systematic reviews 20110216

• OH radical scavenging activity of Edaravone: mechanism and kinetics.

  The journal of physical chemistry. B 20110210

• Towards a selected reaction monitoring mass spectrometry fingerprint approach for the screening of oligosaccharidoses.

  Analytica chimica acta 20110207

• Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone.

  Bioorganic chemistry 20110201

• Effects of continuous intravenous infusion of MCI-186 on functional recovery after spinal cord injury in rats.

  Journal of neurotrauma 20110201

• Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†).

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110201

• Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20110101

• A combined treatment for acute larger lacunar-type infarction.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20110101

• Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells.

  Pancreas 20110101

• Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?

  International immunopharmacology 20110101

• Effect of a free radical scavenger, edaravone, on free radical reactions: related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model.

  Acta neurochirurgica. Supplement 20110101

• Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A comparative study on edaravone derivatives.

  Journal of radiation research 20110101

• Effects of edaravone on a rat model of punch-drunk syndrome.

  Neurologia medico-chirurgica 20110101

• [Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20110101

• Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model.

  Journal of burn care & research : official publication of the American Burn Association 20110101

• Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke.

  BMC neurology 20110101

• Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease.

  PloS one 20110101

• Antioxidant therapy: current status and future prospects.

  Current medicinal chemistry 20110101

• Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs.

  Biological & pharmaceutical bulletin 20110101

• Edaravone attenuates impairment of synaptic plasticity in granule cell layer of the dentate gyrus following traumatic brain injury.

  The Kurume medical journal 20110101

• Protective effects of edaravone on experimental spinal cord injury in rats.

  Pediatric neurosurgery 20110101

• Edaravone: a new therapeutic approach for the treatment of acute stroke.

  Medical hypotheses 20101201

• Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes.

  Biomaterials 20101201

• [ERK1/2 mediates edaravone-triggered protection against myocardial damage induced by isoprenaline in H9c2 cells].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101201

• A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation.

  Neuroscience letters 20101112

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage.

  Current neurovascular research 20101101

• [Concept of branch atheromatous disease (BAD) and its clinical significance].

  Rinsho shinkeigaku = Clinical neurology 20101101

• Gene network analysis to determine the effects of antioxidant treatment in a rat model of neonatal hypoxic-ischemic encephalopathy.

  Journal of molecular neuroscience : MN 20101001

• Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina.

  European journal of pharmacology 20100910

• Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.

  Heart and vessels 20100901

• The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis.

  Free radical research 20100901

• Effects of edaravone on muscle atrophy and locomotor function in patients with ischemic stroke: a randomized controlled pilot study.

  Drugs in R&D 20100901

• 1-(3'-[125I]Iodophenyl)-3-methy-2-pyrazolin-5-one: preparation, solution stability, and biodistribution in normal mice.

  Chemical & pharmaceutical bulletin 20100801

• Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.

  Cancer letters 20100701

• A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?

  Expert opinion on pharmacotherapy 20100701

• Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats.

  Yao xue xue bao = Acta pharmaceutica Sinica 20100701

• A novel method for inducing focal ischemia in vitro.

  Journal of neuroscience methods 20100630

• A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery.

  Journal of neuroscience methods 20100630

• Edaravone directly reacts with singlet oxygen and protects cells from attack.

  Life sciences 20100522

• [A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20100401

• [Effect of edaravone on extracellular signal-regulated kinase 1/2 pathway following severe traumatic brain injury in rats].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20100401

• [Development of a new HPLC technique for analyzing monosaccharide composition and its application in the quality control of Silybum marianum polysaccharide].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100401

• Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.

  European journal of pharmacology 20100325

• Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis.

  BJU international 20100301

• Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms.

  Antioxidants & redox signaling 20100301

• Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.

  Neuroscience research 20100301

• [Protection of edaravone on neurons and its effects on the expression of interleukin-lbeta in juvenile rat hippocampus following status convulsion].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20100301

• Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats.

  The Journal of pharmacy and pharmacology 20100301

• Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model?

  The British journal of radiology 20100201

• Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss.

  Auris, nasus, larynx 20100201

• Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats.

  Neurochemical research 20100201

• Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro.

  Brain research 20100111

• Small temperature variations alter edaravone-induced neuroprotection of cortical cultures exposed to prolonged hypoxic episodes.

  British journal of anaesthesia 20100101

• Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells.

  Neurochemistry international 20100101

• Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function.

  Aktuelle Urologie 20100101

• A novel administration route of edaravone--II: mucosal absorption of edaravone from edaravone/hydroxypropyl-beta-cyclodextrin complex solution including L-cysteine and sodium hydrogen sulfite.

  Pharmacology 20100101

• Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment? A retrospective study of edaravone therapy.

  Clinical drug investigation 20100101

• Protective effect of edaravone against PrP106-126-induced PC12 cell death.

  Journal of biochemical and molecular toxicology 20100101

• Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.

  Biochemical and biophysical research communications 20091225

• Edaravone, a novel free radical scavenger, reduces high-mobility group box 1 and prolongs survival in a neonatal sepsis model.

  Shock (Augusta, Ga.) 20091201

• Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction.

  Journal of cardiology 20091201

• [The protective effect of edaravone on the treatment of sepsis in rats].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20091201

• The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.

  Neurotoxicity research 20091101

• Edaravone (MCI-186) is effective as a free radical scavenger following arteriovenous sheathotomy for treatment of macular oedema associated with branch retinal vein occlusion.

  The British journal of ophthalmology 20091101

• Changes of expression of glucose transporters in the fetal lamb brain after MCI-186 administration to the maternal circulation with 10-min persistent umbilical cord occlusion.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20091001

• Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury.

  Muscle & nerve 20091001

• Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF.

  Journal of neurochemistry 20091001

• Edaravone, a free radical scavenger, retards the development of amygdala kindling in rats.

  Neuroscience letters 20090925

• Antifibrotic effect of edaravone in rat liver cirrhosis induced by dimethylnitrosamine.

  Clinical and experimental medicine 20090901

• Mechanistic insight into neurotoxicity of tissue plasminogen activator-induced thrombolysis products in a rat intraluminal middle cerebral artery occlusion model.

  Journal of neurotrauma 20090901

• Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger.

  BJU international 20090901

• Accumulation of oxidative stress around the stroke-like lesions of MELAS patients.

  Mitochondrion 20090901

• Development of cardiac dysfunction induced by repetitive transient myocardial ischemia is inhibited by edaravone in conscious rats.

  Clinical and experimental pharmacology & physiology 20090901

• Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage.

  Chinese medical journal 20090820

• Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model.

  Neuroscience 20090818

• Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model.

  The British journal of radiology 20090801

• Anterior spinal artery as a collateral channel in patients with acute bilateral vertebral artery occlusions. Two case reports.

  Neurologia medico-chirurgica 20090801

• [Effects of edaravone on the expression of interleukin-1beta, nuclear factor-kappaB and neuron apoptosis in juvenile rat hippocampus after status convulsion].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20090801

• Edaravone, a free radical scavenger, mitigates both gray and white matter damages after global cerebral ischemia in rats.

  Brain research 20090707

• Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells.

  Molecular and cellular biochemistry 20090701

• Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice.

  Laboratory investigation; a journal of technical methods and pathology 20090701

• Therapeutic effect of edaravone on inner ear barotrauma in the guinea pig.

  Neurochemistry international 20090701

• Synthesis, biological evaluation of prenylflavonoids as vasorelaxant and neuroprotective agents.

  Bioorganic & medicinal chemistry letters 20090615

• A novel fluorescent assay for edaravone with aqueous functional CdSe quantum dots.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090601

• Edaravone inhibits DNA peroxidation and neuronal cell death in neonatal hypoxic-ischemic encephalopathy model rat.

  Pediatric research 20090601

• Edaravone in ALS.

  Experimental neurology 20090601

• The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.

  The Journal of pharmacology and experimental therapeutics 20090601

• Electrophysiological study on differentiation of rat bone marrow stromal stem cells into neuron-like cells in vitro by edaravone.

  Chinese journal of traumatology = Zhonghua chuang shang za zhi 20090601

• [Effects of edaravone on IRE1 mRNA expression and neuronal apoptosis in the hippocampus of rats with status convulsivus].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090601

• A novel administration route for edaravone: I. Effects of metabolic inhibitors on skin permeability of edaravone.

  International journal of pharmaceutics 20090508

• Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.

  The Journal of pharmacology and experimental therapeutics 20090501

• Retinal artery embolization during carotid angioplasty and carotid artery stenting: case report.

  Neurologia medico-chirurgica 20090501

• Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart.

  Heart and vessels 20090501

• Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone.

  Clinical and experimental nephrology 20090401

• Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090401

• Protective effects of edaravone against cobalt chloride-induced apoptosis in PC12 cells.

  Neuroscience bulletin 20090401

• Edaravone reduces brain oedema and attenuates cell death after intracerebral haemorrhage in mice.

  Brain injury 20090401

• Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells.

  Journal of neuroscience research 20090301

• Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage.

  Neurosurgery 20090301

• [Topics of the brain protection in neonate, which has been your better choice, the brain hypothermia or the medicine?].

  No to hattatsu = Brain and development 20090301

• Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells.

  Neuroscience 20090218

• Expression of syndecan-2 in the amoeboid microglial cells and its involvement in inflammation in the hypoxic developing brain.

  Glia 20090201

• Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

  Stroke 20090201

• Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress.

  Expert opinion on pharmacotherapy 20090201

• [Edaravone protects hearing from acute acoustic trauma in guinea pigs].

  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20090201

• Edaravone derivatives containing NO-donor functions.

  Journal of medicinal chemistry 20090122

• Edaravone, a free radical scavenger, is effective on neuropathic pain in rats.

  Brain research 20090112

• Protective effect of edaravone against tobramycin-induced ototoxicity.

  Acta oto-laryngologica 20090101

• Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus.

  Seizure 20090101

• Low-dose edaravone injection into the clamped aorta prevents ischemic spinal cord injury.

  Annals of vascular surgery 20090101

• Bilateral middle cerebral artery infarctions following mild varicella infection: a case report.

  Brain & development 20090101

• The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator.

  Experimental neurology 20090101

• Protective effects of free radical scavenger edaravone against xanthine oxidase-mediated permeability increases in human intestinal epithelial cell monolayer.

  Journal of burn care & research : official publication of the American Burn Association 20090101

• [Thrombolysis by intravenous tissue plasminogen activator (t-PA)--current status and future direction].

  Brain and nerve = Shinkei kenkyu no shinpo 20090101

• Signaling pathway on the effect of oxygenated warm perfusion prior to cold preservation of the liver grafts from non-heart-beating donors, and the additive effect of edaravone.

  Transplantation proceedings 20090101

• Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial).

  Cerebrovascular diseases (Basel, Switzerland) 20090101

• Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction.

  Internal medicine (Tokyo, Japan) 20090101

• Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture.

  Journal of anesthesia 20090101

• Repeated edaravone treatment reduces oxidative cell damage in rat brain induced by middle cerebral artery occlusion.

  Redox report : communications in free radical research 20090101

• Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages.

  Shock (Augusta, Ga.) 20081201

• Correlation of free radical level and apoptosis after intracerebral hemorrhage in rats.

  Neuroscience bulletin 20081201

• Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model.

  Neurologia medico-chirurgica 20081201

• Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice.

  The European respiratory journal 20081101

• Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model.

  Journal of pediatric surgery 20081101

• [A comparison of protective effect of propofol and edaravone pretreatment against cerebral ischemia-reperfusion injury].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081101

• [Neuroprotective therapy for ischemic stroke with free radical scavenger and gene-stem cell therapy].

  Rinsho shinkeigaku = Clinical neurology 20081101

• Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis.

  Pulmonary pharmacology & therapeutics 20081001

• Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice.

  Experimental neurology 20081001

• Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.

  Bioorganic & medicinal chemistry 20081001

• [Cardioprotective effect of edaravone pharmacological postconditioning on acute myocardial ischemia/reperfusion injury: experiment with rats].

  Zhonghua yi xue za zhi 20080923

• Protective effects of edaravone against ischemia-induced facial palsy.

  Auris, nasus, larynx 20080901

• Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway.

  Journal of neurochemistry 20080901

• Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice.

  Metabolic brain disease 20080901

• Preventive effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced lung injury in mice.

  Respirology (Carlton, Vic.) 20080901

• A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors.

  Transplantation proceedings 20080901

• [Outcome assessment in treatment of edaravone in childhood ischemic stroke].

  No to hattatsu = Brain and development 20080901

• Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice.

  Neuroscience letters 20080822

• Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model.

  Chinese medical journal 20080820

• Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis.

  Neuroscience letters 20080808

• Edaravone prevents Fas-induced fulminant hepatic failure in mice by regulating mitochondrial Bcl-xL and Bax.

  Shock (Augusta, Ga.) 20080801

• Edaravone (MCI-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats.

  Acta pharmacologica Sinica 20080701

• [Multi-center survey of edaravone treatment in children].

  No to hattatsu = Brain and development 20080701

• Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism.

  Neurologia medico-chirurgica 20080701

• In vitro metabolism study of edaravone in Wistar and hairless rat skin.

  Biological & pharmaceutical bulletin 20080601

• Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats.

  European journal of pharmacology 20080531

• Edaravone prevents kainic acid-induced neuronal death.

  Brain research 20080513

• Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of nuclear factor-kappaB pathway.

  Circulation journal : official journal of the Japanese Circulation Society 20080501

• [Case of transient cortical blindness due to thrombosis of the transverse sinus].

  Rinsho shinkeigaku = Clinical neurology 20080501

• [Protective effects of edaravone on renal ischemia-reperfusion injury in rats].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20080501

• The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice.

  European journal of pharmacology 20080331

• Edaravone prevents iNOS expression by inhibiting its promoter transactivation and mRNA stability in cytokine-stimulated hepatocytes.

  Nitric oxide : biology and chemistry 20080301

• The radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) reacts with a pterin derivative and produces a cytotoxic substance that induces intracellular reactive oxygen species generation and cell death.

  The Journal of pharmacology and experimental therapeutics 20080201

• Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage.

  Stroke 20080201

• Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.

  Anti-cancer drugs 20080201

• Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B.

  Molecular immunology 20080101

• Spontaneous resolution of isolated dissecting aneurysm on the posterior inferior cerebellar artery.

  Acta neurochirurgica 20080101

• Dihydroartemisinin potentiates the cytotoxic effect of temozolomide in rat C6 glioma cells.

  Pharmacology 20080101

• The novel antioxidant edaravone: from bench to bedside.

  Cardiovascular therapeutics 20080101

• Edaravone improves the survival of rats subjected to hemorrhagic shock without resuscitation.

  Surgery today 20080101

• Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons.

  BMC neuroscience 20080101

• Reactive oxygen species generation through NADH oxidation by pterin derivatives.

  Nucleic acids symposium series (2004) 20080101

• Combination drug therapy using edaravone and Daio-Orengedoku-to after transient focal ischemia in rats.

  Methods and findings in experimental and clinical pharmacology 20080101

• Internal carotid artery occlusion manifesting only as oculomotor nerve palsy.

  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20080101

• Novel treatments for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

  Acta neurochirurgica. Supplement 20080101

• Antioxidants and neuroprotection in the adult and developing central nervous system.

  Current medicinal chemistry 20080101

• A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia.

  Brain research 20071205

• Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia.

  Neuroscience research 20071201

• Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats.

  Journal of gastroenterology and hepatology 20071201

• Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance.

  Clinical and experimental nephrology 20071201

• Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one).

  Journal of photochemistry and photobiology. B, Biology 20071112

• Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats.

  Digestive diseases and sciences 20071101

• Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one).

  Drug metabolism and disposition: the biological fate of chemicals 20071101

• Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells.

  American journal of physiology. Cell physiology 20071101

• Protective effect of edaravone against endolymphatic hydrops.

  Acta oto-laryngologica 20071101

• Edaravone, a potent free radical scavenger, prevents anthracycline-induced myocardial cell death.

  Circulation journal : official journal of the Japanese Circulation Society 20071101

• Free radical scavenger edaravone suppresses x-ray-induced apoptosis through p53 inhibition in MOLT-4 cells.

  Journal of radiation research 20071101

• New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.

  Journal of medicinal chemistry 20071018

• Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger.

  Glia 20071001

• MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling.

  Journal of neuroscience research 20071001

• Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats.

  Neurotoxicity research 20071001

• The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress.

  Neuroscience letters 20070823

• Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate.

  Drug metabolism and disposition: the biological fate of chemicals 20070801

• Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo.

  Journal of pharmacological sciences 20070801

• Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy.

  European journal of pharmacology 20070730

• Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.

  The Journal of pharmacology and experimental therapeutics 20070701

• Differential inhibition by oxygen radicals of vasoactive amines-induced contractions in the porcine coronary artery.

  Biological & pharmaceutical bulletin 20070701

• A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20070601

• Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts.

  The Journal of thoracic and cardiovascular surgery 20070601

• Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger.

  Journal of pharmacological sciences 20070501

• Effect of edaravone, a free radical scavenger, on ischemic cerebral edema assessed by magnetic resonance imaging.

  Neurologia medico-chirurgica 20070501

• [Ischemic stroke associated with LH-RH analogue (leuprorelin) administration in a young woman].

  Rinsho shinkeigaku = Clinical neurology 20070501

• Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis.

  Atherosclerosis 20070401

• Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

  Cell death and differentiation 20070401

• Mixed lignan-neolignans from Tarenna attenuata.

  Journal of natural products 20070401

• Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain.

  Journal of pharmacological sciences 20070401

• Melatonin influences the proliferative and differentiative activity of neural stem cells.

  Journal of pineal research 20070401

• Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction.

  The Journal of thoracic and cardiovascular surgery 20070301

• Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury.

  Biological & pharmaceutical bulletin 20070301

• Urgent endarterectomy using pretreatment with free radical scavenger, edaravone, and early clamping of the parent arteries for cervical carotid artery stenosis with crescendo transient ischemic attacks caused by mobile thrombus and hemodynamic cerebral ischemia. Case report.

  Neurologia medico-chirurgica 20070301

• Edaravone inhibits lipid peroxidation in neonatal hypoxic-ischemic rats: an in vivo microdialysis study.

  Neuroscience letters 20070227

• Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?

  Antioxidants & redox signaling 20070201

• Edaravone protects the vestibular periphery from free radical-induced toxicity in response to perilymphatic application of (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid.

  European journal of pharmacology 20070112

• Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.

  Brain research 20070112

• Edaravone reduces ischemia-reperfusion injury mediators in rat liver.

  The Journal of surgical research 20070101

• The specific free radical scavenger edaravone suppresses bleomycin-induced acute pulmonary injury in rabbits.

  Clinical and experimental pharmacology & physiology 20070101

• Effects of edaravone on singlet oxygen released from activated human neutrophils.

  Journal of pharmacological sciences 20070101

• Hydroxyl radical mediates the augmented angiotensin II responses in thoracic aorta of spontaneously hypertensive rats.

  Pharmacology 20070101

• Effects of MCI-186 upon neutrophil-derived active oxygens.

  Redox report : communications in free radical research 20070101

• Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis.

  Journal of neurophysiology 20061201

• Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base.

  Bioorganic & medicinal chemistry letters 20061201

• Anterior and posterior inferior cerebellar artery infarction with sudden deafness and vertigo.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20061201

• Chiral resolution of monosaccharides as 1-phenyl-3-methyl-5-pyrazolone derivatives by ligand-exchange CE using borate anion as a central ion of the chiral selector.

  Electrophoresis 20061201

• Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice.

  Acta pharmacologica Sinica 20061201

• Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study).

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20061201

• Protective effect of radical scavenger edaravone against puromycin nephrosis.

  Clinical nephrology 20061201

• Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits.

  Clinical and experimental pharmacology & physiology 20061101

• [Electron spin resonance method and brain diseases].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20061101

• Alkoxyl radical-scavenging activity of edaravone in patients with traumatic brain injury.

  Journal of neurotrauma 20061101

• [Edaravone].

  Nihon rinsho. Japanese journal of clinical medicine 20061028

• Effects of edaravone on N-methyl-D-aspartate (NMDA)-mediated cytochrome c release and apoptosis in neonatal rat cerebrocortical slices.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20061001

• The therapeutic efficacy of edaravone in extensively burned rats.

  Archives of surgery (Chicago, Ill. : 1960) 20061001

• MCI-186 administered to the maternal circulation inhibits fetal brain injury resulting from total umbilical cord occlusion in the chronically instrumented fetal lamb.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20061001

• Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species.

  Brain research 20060907

• Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria.

  Journal of Zhejiang University. Science. B 20060901

• Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice.

  Circulation journal : official journal of the Japanese Circulation Society 20060901

• Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model.

  Transplantation proceedings 20060901

• Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum.

  European journal of pharmacology 20060807

• MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) attenuated simulated ischemia/reperfusion injury in cultured rat hippocampal cells.

  Biological & pharmaceutical bulletin 20060801

• Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060801

• Hyperbaric oxygen combined with intravenous edaravone for treatment of acute embolic stroke: a pilot clinical trial.

  Neurologia medico-chirurgica 20060801

• Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats.

  Pharmacological research 20060701

• Long-term efficacy of edaravone in patients with acute myocardial infarction.

  Circulation journal : official journal of the Japanese Circulation Society 20060701

• Protective effect of edaravone in inner-ear barotrauma in guinea pigs.

  The Journal of laryngology and otology 20060701

• Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage.

  Free radical research 20060601

• [Advanced medical therapy in patients with acute ischemic stroke].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060601

• An antioxidant treatment potentially protects myocardial energy metabolism by regulating uncoupling protein 2 expression in a chronic beta-adrenergic stimulation rat model.

  Life sciences 20060515

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Apoptosis in ischemic spinal cord injury.

  The Journal of thoracic and cardiovascular surgery 20060501

• The free-radical scavenger, edaravone, augments NO release from vascular cells and platelets after laser-induced, acute endothelial injury in vivo.

  Platelets 20060501

• A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia.

  American journal of physiology. Heart and circulatory physiology 20060401

• Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats.

  Biological & pharmaceutical bulletin 20060401

• Edaravone inhibits the disease activity in rheumatoid arthritis.

  Journal of clinical pharmacy and therapeutics 20060401

• MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060301

• Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion.

  Heart and vessels 20060301

• [Homeostatic conditions affect the protective effect of edaravone on ischemic injury in neurons].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060301

• Edaravone inhibits rheumatoid synovial cell proliferation and migration.

  Free radical research 20060201

• The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice.

  International journal of molecular medicine 20060201

• The production of hydroxyl radicals in the fetal lamb brain resulting from occlusion of the umbilical circulation and the transplacental effect of MCI-186 to inhibit hydroxyl radical production.

  Pediatric research 20060201

• Protective effect of edaravone against the ototoxicity of Pseudomonas aeruginosa exotoxin A.

  Acta oto-laryngologica 20060101

• Edaravone diminishes free radicals from circulating neutrophils in patients with ischemic brain attack.

  Internal medicine (Tokyo, Japan) 20060101

• Reactive oxygen species generated by mitochondrial injury in human brain microvessel endothelial cells.

  Clinical hemorheology and microcirculation 20060101

• Edaravone in acute ischemic stroke.

  Internal medicine (Tokyo, Japan) 20060101

• Efficacy of edaravone in cardioembolic stroke.

  Internal medicine (Tokyo, Japan) 20060101

• New modalities for the treatment of acute cardioembolic stroke.

  Internal medicine (Tokyo, Japan) 20060101

• Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury.

  CNS drug reviews 20060101

• Cardioprotective effect of edaravone against ischaemia-reperfusion injury in the rabbit heart before, during and after reperfusion treatment.

  The Journal of international medical research 20060101

• Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases.

  Recent patents on cardiovascular drug discovery 20060101

• Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure.

  Circulation 20051206

• Dielectric relaxation spectroscopy of heteronuclear cobalt(II)-copper(II) complex of 1-phenyl-3-methyl-5-pyrazolone.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051201

• MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats.

  American journal of physiology. Heart and circulatory physiology 20051201

• Experimental study on the protective effects of edaravone against ischemic spinal cord injury.

  The Journal of thoracic and cardiovascular surgery 20051201

• The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB.

  Cancer letters 20051118

• Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy.

  Stroke 20051101

• A free radical scavenger, edaravone, inhibits lipid peroxidation and the production of nitric oxide in hypoxic-ischemic brain damage of neonatal rats.

  American journal of obstetrics and gynecology 20051101

• Post-exposure administration of edaravone attenuates noise-induced hearing loss.

  European journal of pharmacology 20051017

• Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction.

  Free radical biology & medicine 20051015

• Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats.

  Pediatric nephrology (Berlin, Germany) 20051001

• Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain.

  Stroke 20051001

• Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy.

  Surgical neurology 20051001

• Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder.

  Urology 20051001

• Analysis of the monosaccharide components in Angelica polysaccharides by high performance liquid chromatography.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20051001

• Protective effect of a radical scavenger, MCI-186 on islet cell damages induced by oxidative stress.

  Transplantation proceedings 20051001

• [Bilateral multiple border zone infarctions after massive bleeding: report of two cases].

  Rinsho shinkeigaku = Clinical neurology 20051001

• The role of edaravone on the impairment of endothelial barrier function induced by acute oxidative stress in cultured human umbilical vein endothelial cell monolayer.

  The Journal of trauma 20050901

• Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity.

  Journal of neurochemistry 20050801

• Effect of the free radical scavenger MCI-186 on spinal cord reperfusion after transient ischemia in the rabbit.

  The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20050801

• A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation.

  Transplantation 20050727

• MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats.

  Transplant international : official journal of the European Society for Organ Transplantation 20050701

• Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat.

  Journal of cardiovascular pharmacology 20050701

• Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats.

  Neurological research 20050701

• Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model.

  Neurological research 20050701

• Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction.

  Neurologia medico-chirurgica 20050701

• Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats.

  European journal of pharmacology 20050601

• [A case of stroke-like episode of MELAS of which progressive spread would be prevented by edaravone].

  Rinsho shinkeigaku = Clinical neurology 20050601

• Neuroprotection and enhanced recovery with edaravone after acute spinal cord injury in rats.

  Spine 20050515

• High performance liquid chromatographic determination of N-butyryl glucosamine in rat plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

• The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy.

  Hypertension (Dallas, Tex. : 1979) 20050501

• Influence of the labeling group on ionization and fragmentation of carbohydrates in mass spectrometry.

  Journal of the American Society for Mass Spectrometry 20050501

• A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model.

  Critical care medicine 20050501

• Bacterial translocation in hemorrhagic shock: Are we any wiser?

  Critical care medicine 20050501

• Bacterial translocation and intestinal neutrophil lipid peroxidation in a hemorrhagic shock model--Rat race or rat trap?

  Critical care medicine 20050501

• Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus.

  European journal of pharmacology 20050411

• ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats.

  Acta pharmacologica Sinica 20050401

• Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.

  Current drug targets. CNS and neurological disorders 20050401

• Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain.

  Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20050401

• Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase.

  Atherosclerosis 20050301

• Effects of edaravone on human neutrophil function.

  Acta anaesthesiologica Scandinavica 20050301

• A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats.

  The Journal of pharmacology and experimental therapeutics 20050201

• Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat.

  Free radical biology & medicine 20050201

• The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia.

  Neuropharmacology 20050201

• Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats.

  Acta anaesthesiologica Scandinavica 20050201

• [Treatment of cerebral infarction patients with IGT].

  Nihon rinsho. Japanese journal of clinical medicine 20050201

• Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.

  Pharmacology 20050101

• Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats.

  Journal of hepatology 20050101

• [A case of common carotid artery dissection showing remission in short-term].

  No shinkei geka. Neurological surgery 20050101

• MCI-186 inhibits tumor growth through suppression of EGFR phosphorylation and cell cycle arrest.

  Anticancer research 20050101

• Effects of a free radical scavenger, MCI-186, on ischemia-reperfusion injury during extended liver resection in dogs.

  Hepato-gastroenterology 20050101

• Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia.

  Brain research 20041217

• [Clinical guidelines for stroke].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20041110

• Pretreatment with the free radical scavenger edaravone prevents cerebral hyperperfusion after carotid endarterectomy.

  Neurosurgery 20041101

• EPR imaging to estimate the in vivo intracerebral reducing ability of mature rats after neonatal hypoxic-ischemic brain injury.

  Magnetic resonance imaging 20041101

• Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers.

  The American journal of cardiology 20041015

• Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction.

  The Journal of pharmacology and experimental therapeutics 20041001

• Effect of edaravone on streptomycin-induced vestibulotoxicity in the Guinea pig.

  The Laryngoscope 20040901

• Effects of edaravone on reperfusion injury in patients with acute myocardial infarction.

  The American journal of cardiology 20040815

• Antioxidant effect of MCI-186, a new Free-Radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model.

  The Journal of surgical research 20040801

• MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia.

  The Annals of thoracic surgery 20040801

• Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats.

  Brain research. Developmental brain research 20040719

• Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion.

  Journal of the neurological sciences 20040615

• Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes.

  British journal of pharmacology 20040601

• In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone; Radicut), a clinical drug.

  Journal of radiation research 20040601

• Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.

  Kidney international 20040501

• Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats.

  Journal of the neurological sciences 20040415

• Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain.

  Neurological research 20040401

• Edaravone inhibits acute renal injury and cyst formation in cisplatin-treated rat kidney.

  Free radical research 20040401

• The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma.

  European journal of pharmacology 20040308

• [Research and development of the free radical scavenger edaravone as a neuroprotectant].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301

• The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical.

  Chemical & pharmaceutical bulletin 20040201

• The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury.

  The British journal of surgery 20040201

• [Effects of edaravone, minocycline and ONO-1078 on oxygen/glucose deprivation-induced electrophysiological alteration in rat hippocampal slices].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040201

• Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats.

  International journal of molecular medicine 20040101

• [Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040101

• A new free radical scavenger, edaravone, ameliorates oxidative liver damage due to ischemia-reperfusion in vitro and in vivo.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20040101

• Protective effects of a free radical scavenger, MCI-186, on high-glucose-induced dysfunction of human dermal microvascular endothelial cells.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20040101

• Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.

  Biological & pharmaceutical bulletin 20031201

• [An improved quantitative method for evaluation of ischemic injury and neuroprotection in mouse brain slices].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031201

• A theoretical investigation on DPPH radical-scavenging mechanism of edaravone.

  Bioorganic & medicinal chemistry letters 20031103

• Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression.

  American journal of physiology. Heart and circulatory physiology 20031101

• High-speed electrophoretic analysis of 1-phenyl-3-methyl-5-pyrazolone derivatives of monosaccharides on a quartz microchip with whole-channel UV detection.

  Electrophoresis 20031101

• MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits.

  The Journal of thoracic and cardiovascular surgery 20031101

• [Advances in the diagnosis and treatment of cerebral ischemia during the acute phase].

  Rinsho shinkeigaku = Clinical neurology 20031101

• [Gene therapy and neuroprotection for cerebral infarction].

  Rinsho shinkeigaku = Clinical neurology 20031101

• Free radical scavenger protects against inner hair cell loss after cochlear ischemia.

  Neuroreport 20031006

• Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin.

  The Journal of pharmacology and experimental therapeutics 20031001

• Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression.

  European journal of pharmacology 20030822

• Determination of 1-phenyl-3-methyl-5-pyrazolone-labeled carbohydrates by liquid chromatography and micellar electrokinetic chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030805

• A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury.

  Free radical research 20030801

• The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats.

  International journal of molecular medicine 20030701

• The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats.

  International journal of molecular medicine 20030701

• Clinical usefulness of edaravone for acute liver injury.

  Journal of gastroenterology and hepatology 20030701

• [The clinical effect of combination therapy with edaravone and sodium ozagrel for acute cerebral infarction].

  No to shinkei = Brain and nerve 20030701

• Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice.

  Toxicology letters 20030605

• A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo.

  The Journal of pharmacology and experimental therapeutics 20030601

• Efficacy of edaravone, a free radical scavenger, on left ventricular function and structure in diabetes mellitus.

  Journal of cardiovascular pharmacology 20030601

• Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver.

  European journal of pharmacology 20030328

• Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig.

  European journal of pharmacology 20030307

• Analysis of carbohydrates as 1-phenyl-3-methyl-5-pyrazolone derivatives by capillary/microchip electrophoresis and capillary electrochromatography.

  Journal of pharmaceutical and biomedical analysis 20030115

• Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters.

  Cerebrovascular diseases (Basel, Switzerland) 20030101

• Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone).

  Redox report : communications in free radical research 20030101

• Synthesis of the metabolites of a free radical scavenger edaravone (MCI-186, Radicut).

  Redox report : communications in free radical research 20030101

• Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger.

  Arzneimittel-Forschung 20030101

• Effects of edaravone on experimental brain injury in view of free radical reaction.

  Acta neurochirurgica. Supplement 20030101

• Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger.

  Acta neurochirurgica 20021201

• Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.

  Transplantation 20021127

• Myocardial protection of MCI-186 in rabbit ischemia-reperfusion.

  Life sciences 20020927

• Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats.

  European journal of pharmacology 20020913

• Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats.

  Neuroscience letters 20020823

• A study of immunoglobulin G glycosylation in monoclonal and polyclonal species by electrospray and matrix-assisted laser desorption/ionization mass spectrometry.

  Analytical biochemistry 20020601

• [Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20020501

• Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils.

  Neuroscience research 20020501

• Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry.

  Clinical chemistry 20020101

• Automated structural assignment of derivatized complex N-linked oligosaccharides from tandem mass spectra.

  Rapid communications in mass spectrometry : RCM 20020101

• Edarabone scavenges nitric oxide.

  Redox report : communications in free radical research 20020101

• [Experience of biologically active supplements to food containing indoles and isothiocyanates in patients with chronic viral hepatitis].

  Voprosy pitaniia 20020101

• [Neuroprotective therapy for the treatment of acute ischemic stroke].

  Rinsho shinkeigaku = Clinical neurology 20011201

• Investigation of different combinations of derivatization, separation methods and electrospray ionization mass spectrometry for standard oligosaccharides and glycans from ovalbumin.

  Journal of mass spectrometry : JMS 20010501

• Capillary electrophoretic analysis of carbohydrates derivatized by in-capillary condensation with 1-phenyl-3-methyl-5-pyrazolone.

  Journal of chromatography. A 20010316

• Analysis of sialo-N-glycans in glycoproteins as 1-phenyl-3-methyl-5-pyrazolone derivatives by capillary electrophoresis.

  Journal of chromatography. A 20010302