890842-28-1 | 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$20.00	$14.00
5mg	99%	in stock	$47.00	$33.00
10mg	99%	in stock	$72.00	$51.00
50mg	99%	in stock	$217.00	$152.00

Description

• Catalog Number: AB86729
• Chemical Name: 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
• CAS Number: 890842-28-1
• Molecular Formula: C25H22N2O2
• Molecular Weight: 382.4543799999999
• MDL Number: MFCD12828779
• SMILES: OC(=O)c1ccc(cc1C1CCCC1)c1c[nH]c2c1cc(cn2)c1ccccc1

Computed Properties

• Complexity: 569
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 6.1

Literature

• Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport.

  The Journal of biological chemistry 20160902

• Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.

  Bioorganic & medicinal chemistry letters 20120901

• Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.

  The Journal of biological chemistry 20110916

• Selectivity of kinase inhibitor fragments.

  Journal of medicinal chemistry 20110728

• Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption.

  British journal of pharmacology 20101001

• Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.

  Bioorganic & medicinal chemistry letters 20090801

• Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.

  Cancer research 20080915