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The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.
Chemico-biological interactions 20160125
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Featured Article: Hypoxia-inducible factor-1α dependent nuclear entry of factor inhibiting HIF-1.
Experimental biology and medicine (Maywood, N.J.) 20151101
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Targeting the hypoxia-sensing pathway in clinical hematology.
Stem cells translational medicine 20140201
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Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
The international journal of biochemistry & cell biology 20131101
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Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues.
The American journal of pathology 20121101
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Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor in dental pulp-derived cells.
Journal of endodontics 20121101
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α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).
Pflugers Archiv : European journal of physiology 20121001
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Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes.
Journal of cellular and molecular medicine 20120901
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Increased activation of the hypoxia-inducible factor pathway in varicose veins.
Journal of vascular surgery 20120501
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Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.
Journal of medicinal chemistry 20120412
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Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts.
Journal of periodontal research 20120401
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HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice.
Journal of hepatology 20120201
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Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α.
Neurobiology of disease 20120201
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Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism.
Journal of dermatological science 20120201
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Systemic preconditioning by a prolyl hydroxylase inhibitor promotes prevention of skin flap necrosis via HIF-1-induced bone marrow-derived cells.
PloS one 20120101
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Hypoxia-inducible factor activation protects the kidney from gentamicin-induced acute injury.
PloS one 20120101
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Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis.
Biochemical and biophysical research communications 20111216
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Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase.
Molecular and cellular biochemistry 20111201
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Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms.
Laboratory investigation; a journal of technical methods and pathology 20111201
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Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.
American journal of physiology. Lung cellular and molecular physiology 20111201
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Hypoxia induced expression of histone lysine demethylases: implications in oxygen-dependent retinal neovascular diseases.
Biochemical and biophysical research communications 20111118
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Hypoxia-inducible factor regulates expression of surfactant protein in alveolar type II cells in vitro.
American journal of respiratory cell and molecular biology 20111101
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Curcumin provides potential protection against the activation of hypoxia and prolyl 4-hydroxylase inhibitors on prostate-specific antigen expression in human prostate carcinoma cells.
Molecular nutrition & food research 20111101
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Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using μPET/CT.
Inflammatory bowel diseases 20111001
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Inhibition of prolyl hydroxylase domain-containing protein downregulates vascular angiotensin II type 1 receptor.
Hypertension (Dallas, Tex. : 1979) 20110901
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The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells.
Shock (Augusta, Ga.) 20110901
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Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo.
Plastic and reconstructive surgery 20110801
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Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1α and VEGF production and improves functional recovery after acute ischemia/reperfusion.
Surgery 20110801
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Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells.
The Journal of surgical research 20110515
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Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue.
Blood 20110505
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[Effects of dimethyloxalyl glycine on hypoxic-ischemic brain damage in newborn rats].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110501
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Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor.
Journal of immunology (Baltimore, Md. : 1950) 20110401
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Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.
British journal of cancer 20110329
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HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.
Blood 20110324
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Structural basis for human PHF2 Jumonji domain interaction with metal ions.
Journal of molecular biology 20110211
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Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201
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Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110101
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Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells.
Biological & pharmaceutical bulletin 20110101
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Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.
PloS one 20110101
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von Hippel-Lindau β-domain-luciferase fusion protein as a bioluminescent hydroxyproline sensor for a hypoxia-inducible factor prolyl hydroxylase assay.
Analytical biochemistry 20101215
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Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade.
American journal of physiology. Renal physiology 20101201
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Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.
Journal of immunology (Baltimore, Md. : 1950) 20101115
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Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3.
Reproductive sciences (Thousand Oaks, Calif.) 20100901
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Force field design and molecular dynamics simulations of factor-inhibiting HIF-1 and its complex with known inhibitors: implications for rational inhibitor design.
Journal of molecular graphics & modelling 20100901
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Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
Journal of medicinal chemistry 20100812
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Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule-1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950) 20100801
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Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus.
Neuroscience 20100602
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Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast.
Endocrinology 20100601
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Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway.
The Journal of biological chemistry 20100319
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Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia.
American journal of physiology. Renal physiology 20100301
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FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells.
The Journal of biological chemistry 20100212
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Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1alpha.
Basic research in cardiology 20100101
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Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100101
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Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.
Cancer science 20100101
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Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression.
Arteriosclerosis, thrombosis, and vascular biology 20091201
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Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma.
International journal of colorectal disease 20091101
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Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20091101
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Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20091001
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Interferon-gamma induces prolyl hydroxylase (PHD)3 through a STAT1-dependent mechanism in human endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 20090901
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Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 20090630
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Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
Bioorganic & medicinal chemistry letters 20090515
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Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.
Molecular pharmacology 20090501
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Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival.
Journal of cellular biochemistry 20090401
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Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
Molecular & cellular proteomics : MCP 20090301
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Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease.
Nature reviews. Drug discovery 20090201
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HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation.
Vascular pharmacology 20090101
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Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes.
Vascular pharmacology 20090101
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Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
The Biochemical journal 20081215
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A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.
Molecular cancer therapeutics 20081201
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HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model.
Neurobiology of disease 20080901
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Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning.
Circulation 20080708
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O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration.
American journal of physiology. Cell physiology 20080701
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Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes.
Pflugers Archiv : European journal of physiology 20080501
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DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension.
The Journal of steroid biochemistry and molecular biology 20080301
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The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.
Gastroenterology 20080101
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Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints.
Arthritis research & therapy 20080101
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Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation.
Journal of neurochemistry 20071201
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HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.
American journal of physiology. Endocrinology and metabolism 20071201
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Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes.
Arthritis and rheumatism 20071201
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Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.
The Journal of biological chemistry 20070914
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Effect of chemical stabilizers of hypoxia-inducible factors on early lung development.
American journal of physiology. Lung cellular and molecular physiology 20070901
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HIF stabilizing agents: shotgun or scalpel?
American journal of physiology. Lung cellular and molecular physiology 20070901
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Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance.
Acta physiologica (Oxford, England) 20070601
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Hypoxia inducible factor-1 modulates hemin-induced IL-8 secretion in microvascular endothelium.
Microvascular research 20070501
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Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha.
Biochemical pharmacology 20070301
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The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition.
American journal of physiology. Cell physiology 20070201
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Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway.
Oncogene 20070111
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Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity.
Journal of cellular physiology 20070101
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Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
The Journal of biological chemistry 20060602
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Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes.
Biochemical and biophysical research communications 20060310
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[HIF-1alpha, HIF-2alpha and VHL mRNA expression in different cell lines during hypoxia].
Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20060101
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Kinetic and spectroscopic investigation of CoII, NiII, and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase, TauD.
Biochemical and biophysical research communications 20051209
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HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation.
American journal of physiology. Heart and circulatory physiology 20050801
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Activation of hypoxia-induced transcription in normoxia.
Experimental cell research 20050515
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Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron.
Experimental cell research 20050515
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Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.
American journal of physiology. Cell physiology 20050501
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OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Molecular cell 20050218
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Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.
Acta biochimica Polonica 20050101
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Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.
The Journal of physiology 20041001
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Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
The Journal of biological chemistry 20021018
