897016-82-9 | N-Benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$19.00	$14.00
5mg	98+%	in stock	$46.00	$33.00
250mg	98	in stock	$2,132.00	$1,492.00

Description

• Catalog Number: AH85316
• Chemical Name: N-Benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide
• CAS Number: 897016-82-9
• Molecular Formula: C26H29N3O3
• Molecular Weight: 431.5268
• MDL Number: MFCD18633218
• SMILES: O=C(Cc1ccc(cn1)c1ccc(cc1)OCCN1CCOCC1)NCc1ccccc1

Computed Properties

• Complexity: 540
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 9
• XLogP3: 2.9

Literature

• Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).

  Journal of medicinal chemistry 20180614

• A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies.

  Investigational new drugs 20130801

• KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer.

  Breast cancer research and treatment 20120401

• Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities.

  European journal of medicinal chemistry 20111001

• Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors.

  Bioorganic & medicinal chemistry 20110415

• Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance.

  Journal of medicinal chemistry 20100211

• Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro.

  Digestive diseases and sciences 20090701