898044-15-0 | Pf-3758309

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$18.00	$13.00
5mg	98%	in stock	$43.00	$30.00
10mg	98%	in stock	$64.00	$45.00
50mg	98%	in stock	$177.00	$124.00

Description

• Catalog Number: AH85371
• Chemical Name: Pf-3758309
• CAS Number: 898044-15-0
• Molecular Formula: C25H30N8OS
• Molecular Weight: 490.62370000000004
• MDL Number: MFCD18633226
• SMILES: CN(C[C@H](c1ccccc1)NC(=O)N1Cc2c(C1(C)C)[nH]nc2Nc1nc(C)nc2c1scc2)C

Computed Properties

• Complexity: 747
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6
• XLogP3: 3.1

Literature

• Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.

  ACS medicinal chemistry letters 20150709

• Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

  Journal of medicinal chemistry 20140213

• Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.

  Proceedings of the National Academy of Sciences of the United States of America 20100518