905586-69-8 | Az 960

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$46.00	$33.00
2mg	97%	in stock	$82.00	$57.00
5mg	97%	in stock	$137.00	$96.00
10mg	97%	in stock	$234.00	$164.00
25mg	97%	in stock	$409.00	$287.00
50mg	97%	in stock	$511.00	$358.00

Description

• Catalog Number: AH82400
• Chemical Name: Az 960
• CAS Number: 905586-69-8
• Molecular Formula: C18H16F2N6
• Molecular Weight: 354.35664640000005
• MDL Number: MFCD16621127
• SMILES: N#Cc1cc(F)c(nc1N[C@H](c1ccc(cc1)F)C)Nc1n[nH]c(c1)C

Computed Properties

• Complexity: 503
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 5
• XLogP3: 4.4

Literature

• Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia.

  International journal of cancer 20111115

• In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20110515

• AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells.

  Molecular cancer therapeutics 20101201

• Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.

  The Journal of biological chemistry 20081121