90729-42-3 | Carebastine

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$70.00	$49.00
10mg	98%	in stock	$108.00	$76.00
25mg	98%	in stock	$151.00	$106.00
100mg	98%	in stock	$523.00	$366.00
250mg	98%	in stock	$927.00	$649.00
1g	98%	in stock	$3,117.00	$2,182.00

Description

• Catalog Number: AH88957
• Chemical Name: Carebastine
• CAS Number: 90729-42-3
• Molecular Formula: C32H37NO4
• Molecular Weight: 499.6405
• MDL Number: MFCD00865665
• SMILES: OC(=O)C(c1ccc(cc1)C(=O)CCCN1CCC(CC1)OC(c1ccccc1)c1ccccc1)(C)C

Computed Properties

• Complexity: 690
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 37
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 11
• XLogP3: 3.6

Literature

• Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression.

  Journal of pharmacological sciences 20120101

• Histamine modulates the responsiveness of keratinocytes to IL-17 and TNF-α through the H1-receptor.

  Journal of dermatological science 20110101

• Application of a rapid and selective method for the simultaneous determination of carebastine and pseudoephedrine in human plasma by liquid chromatography-electrospray mass spectrometry for bioequivalence study in Korean subjects.

  Biomedical chromatography : BMC 20101001

• Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants.

  Journal of clinical pharmacology 20100201

• Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice.

  Biopharmaceutics & drug disposition 20091201

• Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling.

  The European respiratory journal 20091001

• Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor.

  Clinical and experimental dermatology 20081101

• The effect of H1 antagonists carebastine and olopatadine on histamine induced expression of CC chemokines in cultured human nasal epithelial cells.

  Allergology international : official journal of the Japanese Society of Allergology 20070601

• Pharmacokinetics and safety of ebastine in healthy subjects and patients with renal impairment.

  Clinical pharmacokinetics 20070101

• Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.

  Drug metabolism and disposition: the biological fate of chemicals 20061101

• The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study.

  British journal of clinical pharmacology 20060801

• Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine.

  Bioorganic & medicinal chemistry letters 20041101

• Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.

  Current medical research and opinion 20040101

• In vivo evidence for a lack of central effect of ebastine, an antihistaminic agent, in rats: a microdialysis study.

  Japanese journal of pharmacology 20021201

• A double-blind, placebo-controlled study of the efficacy and safety of ebastine 20 mg once daily given with and without food in the treatment of seasonal allergic rhinitis.

  Journal of clinical pharmacology 20021001

• Cardiotoxicity of new antihistamines and cisapride.

  Toxicology letters 20020227

• Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography.

  Journal of chromatography. B, Biomedical sciences and applications 20010605

• Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects.

  International journal of clinical pharmacology and therapeutics 20010301

• Regulatory effect of histamine H1 receptor antagonist on the expression of messenger RNA encoding CC chemokines in the human nasal mucosa.

  The Journal of allergy and clinical immunology 20010101

• Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels.

  European journal of pharmacology 19970520