911222-45-2 | LY2603618

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$17.00	$12.00
5mg	95%	in stock	$44.00	$31.00
25mg	95%	in stock	$204.00	$143.00
50mg	95%	in stock	$304.00	$213.00

Description

• Catalog Number: AH85325
• Chemical Name: LY2603618
• CAS Number: 911222-45-2
• Molecular Formula: C18H22BrN5O3
• Molecular Weight: 436.30297999999993
• MDL Number: MFCD18633253
• SMILES: O=C(Nc1cc(Br)c(cc1OC[C@@H]1CNCCO1)C)Nc1cnc(cn1)C

Computed Properties

• Complexity: 486
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 5
• XLogP3: 1.4

Literature

• Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.

  Investigational new drugs 20140401

• Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.

  Toxicological sciences : an official journal of the Society of Toxicology 20131001

• Summary of presentation from the targeted therapy in lung cancer meeting.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20111101

• New insights into checkpoint kinase 1 in the DNA damage response signaling network.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100115