-
Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.
Neurotoxicology 20151201
-
Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats.
Neuropharmacology 20121201
-
DNA-binding, spectroscopic and antimicrobial studies of palladium(II) complexes containing 2,2'-bipyridine and 1-phenylpiperazine.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121001
-
Phenylpiperazine derivatives: a patent review (2006 - present).
Expert opinion on therapeutic patents 20121001
-
Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters.
ACS chemical neuroscience 20120919
-
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.
Bioorganic & medicinal chemistry letters 20120715
-
Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α₁-adrenoceptor affinities.
Bioorganic & medicinal chemistry 20120401
-
FT-IR and Raman spectroscopic and quantum chemical investigations of some metal halide complexes of 1-phenylpiperazine.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120301
-
3-(Adamantan-1-yl)-4-phenyl-1-[(4-phenyl-piperazin-1-yl)meth-yl]-1H-1,2,4-triazole-5(4H)-thione.
Acta crystallographica. Section E, Structure reports online 20120201
-
[Design, synthesis and characterization of cyanopyrrolidine-bearing compounds as DPP-4 inhibitors].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120201
-
Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.
Bioorganic & medicinal chemistry 20120115
-
Bivalent molecular probes for dopamine D2-like receptors.
Bioorganic & medicinal chemistry 20120101
-
Rates of 5 common antidepressant side effects among new adult and adolescent cases of depression: a retrospective US claims study.
Clinical therapeutics 20120101
-
How full is our antihypertensives pipeline?
Journal of pharmacology & pharmacotherapeutics 20120101
-
Synthesis and evaluation of a series of 2-substituted-5-thiopropylpiperazine (piperidine)-1,3,4-oxadiazoles derivatives as atypical antipsychotics.
PloS one 20120101
-
Synthesis and vibrational spectroscopic analysis of some Hofmann type clathrates.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101
-
Ligand discovery from a dopamine D3 receptor homology model and crystal structure.
Nature chemical biology 20111101
-
10α-Hy-droxy-4,9-dimethyl-13-[(4-phenyl-piperazin-1-yl)meth-yl]-3,8,15-trioxatetra-cyclo-[10.3.0.0.0]tetra-decan-14-one.
Acta crystallographica. Section E, Structure reports online 20111101
-
Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones.
Bioorganic & medicinal chemistry letters 20111001
-
Molecular dynamics study of small molecule inhibitors of the Bcl-2 family.
Proteins 20110901
-
Biophysical mapping of the adenosine A2A receptor.
Journal of medicinal chemistry 20110714
-
Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum.
Neuroreport 20110713
-
Synthesis and antibacterial activity of pentacyclines: a novel class of tetracycline analogs.
Journal of medicinal chemistry 20110609
-
N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.
Journal of medicinal chemistry 20110526
-
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 20110414
-
Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor.
Molecular pharmacology 20110301
-
The clinical toxicology of the designer 'party pills' benzylpiperazine and trifluoromethylphenylpiperazine.
Clinical toxicology (Philadelphia, Pa.) 20110301
-
The effects of the 4-(4-Methylpiperazine)phenyl group on nucleosides and oligonucleotides: cellular delivery, detection, and stability.
Chemistry, an Asian journal 20110201
-
Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on L-dopa dependent animal involuntary movements in rats.
Neuropharmacology 20110101
-
Antidepressant-like activity of the phenylpiperazine pyrrolidin-2-one derivatives in mice.
Pharmacological reports : PR 20110101
-
A novel structural framework for α(1A/D)-adrenoceptor selective antagonists identified using subtype selective pharmacophores.
PloS one 20110101
-
Structure-cardiovascular activity relationships in a group of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3-aminopropyl)-3,7-dihydro-1H-purine-2,6-diones.
Pharmacological reports : PR 20110101
-
Oxidation of fluoroquinolone antibiotics and structurally related amines by chlorine dioxide: Reaction kinetics, product and pathway evaluation.
Water research 20101201
-
Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin.
Bioorganic & medicinal chemistry letters 20101015
-
Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry.
Journal of chromatography. A 20101001
-
1-Phenyl-piperazine-1,4-diium bis-(hydrogen sulfate).
Acta crystallographica. Section E, Structure reports online 20101001
-
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.
Bioorganic & medicinal chemistry 20100915
-
4-Phenyl-piperazin-1-ium dihydrogen phosphate.
Acta crystallographica. Section E, Structure reports online 20100901
-
[3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen.
Synapse (New York, N.Y.) 20100601
-
Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.
Bioorganic & medicinal chemistry letters 20100501
-
Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).
Journal of medicinal chemistry 20100325
-
Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways.
Synapse (New York, N.Y.) 20100301
-
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.
Bioorganic & medicinal chemistry 20100301
-
Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: a new step towards the design of high-affinity 5-HT1A ligands.
Bioorganic & medicinal chemistry letters 20100201
-
Animal violence demystified.
Frontiers in behavioral neuroscience 20100101
-
Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.
The open medicinal chemistry journal 20100101
-
[(18)F]-labeled 2-methoxyphenylpiperazine derivative as a potential brain positron emission tomography imaging agent.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20091101
-
Construction of drug screening cell model and application to new compounds inhibiting FITC-fibrinogen binding to CHO cells expressing human alphaIIbbeta3.
European journal of pharmacology 20090915
-
[(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization.
Synapse (New York, N.Y.) 20090901
-
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
Journal of medicinal chemistry 20090813
-
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.
Bioorganic & medicinal chemistry 20090701
-
Acaricidal properties of piperazine and its derivatives against house-dust and stored-food mites.
Pest management science 20090601
-
1-Chloro-2-(4-phenyl-piperazin-1-yl)ethanone.
Acta crystallographica. Section E, Structure reports online 20090601
-
Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.
Journal of medicinal chemistry 20090528
-
Application of a library of artificial receptors formed by the self-organization of N-lipidated peptides immobilized on cellulose in studying the effects of the incorporation of a fluorine atom.
Journal of combinatorial chemistry 20090101
-
Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats.
Neuropharmacology 20090101
-
Synthesis and pharmacological evaluation of new 1-[3-(4-phenylpiperazin-1-yl)-propyl]- and 1-[3-(4-phenylpiperidine)-propyl]- 3-aryl-3-alkyl-pyrrolidin-2-one derivatives with antiarrhythmic and antihypertensive activity.
Acta poloniae pharmaceutica 20090101
-
SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression.
European journal of pharmacology 20081119
-
Probe compounds to quantify cation exchange and complexation interactions of ciprofloxacin with soils.
Environmental science & technology 20081115
-
Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues.
Bioorganic & medicinal chemistry 20080901
-
NO-donors. Part 17: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds.
Bioorganic & medicinal chemistry 20080901
-
FT-IR spectroscopic investigation of some Hofmann type complexes: M(1-phenylpiperazine)2Ni(CN)4 (M=Ni, Co, Cd, Pd or Mn).
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080701
-
1-(4-Chloro-phen-yl)piperazine-1,4-diium tetra-chlorido-zincate(II) monohydrate.
Acta crystallographica. Section E, Structure reports online 20080701
-
Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin.
Bioorganic & medicinal chemistry 20080601
-
Pharmacokinetic evaluation of LASSBio-579: an N-phenylpiperazine antipsychotic prototype.
The Journal of pharmacy and pharmacology 20080601
-
(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists.
Journal of medicinal chemistry 20080424
-
Determination of lipophilicity of alpha-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods.
Biomedical chromatography : BMC 20080401
-
Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581.
Pharmacology, biochemistry, and behavior 20080301
-
Trazodone for Alzheimer's disease: a naturalistic follow-up study.
Archives of gerontology and geriatrics 20080101
-
Two new phenylpiperazines with atypical antipsychotic potential.
Bioorganic & medicinal chemistry letters 20071101
-
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
Journal of medicinal chemistry 20070726
-
FT-IR and NMR investigation of 1-phenylpiperazine: a combined experimental and theoretical study.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701
-
Synthesis and in vitro evaluation of substituted phenyl-piperazinyl-phenyl oxazolidinones against Gram-positive bacteria.
Chemical biology & drug design 20070401
-
Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp.
Journal of industrial microbiology & biotechnology 20070301
-
Adsorption and oxidation of fluoroquinolone antibacterial agents and structurally related amines with goethite.
Chemosphere 20070101
-
Patented small molecule inhibitors in the ubiquitin proteasome system.
BMC biochemistry 20070101
-
Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives.
Bioorganic & medicinal chemistry 20061115
-
Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.
Journal of medicinal chemistry 20060824
-
BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: chromene, coumarin and quinoline.
Bioorganic & medicinal chemistry letters 20060401
-
Binding and photocleavage of cationic porphyrin-phenylpiperazine hybrids to DNA.
Biophysical chemistry 20060201
-
In vitro metabolism studies of (18)F-labeled 1-phenylpiperazine using mouse liver S9 fraction.
Nuclear medicine and biology 20060201
-
Hepatic metabolism of two alpha-1A-adrenergic receptor antagonists, phthalimide-phenylpiperazine analogs (RWJ-69205 and RWJ-69471), in the rat, dog and human.
European journal of drug metabolism and pharmacokinetics 20060101
-
Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents.
Bioorganic & medicinal chemistry letters 20051101
-
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.
Bioorganic & medicinal chemistry letters 20051101
-
Complete assignments of 1H and 13C NMR data for ten phenylpiperazine derivatives.
Magnetic resonance in chemistry : MRC 20051001
-
Pharmacokinetics and tissue distribution of a new heterocyclic N-phenylpiperazine derivative (LASSBio-581) in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051001
-
[A study of physicochemical properties of 2-, 3-, 4-alkoxyphenylcarbamic acid derivatives with a substituted N-phenylpiperazine moiety in the basic part].
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20050901
-
Oxidative transformation of fluoroquinolone antibacterial agents and structurally related amines by manganese oxide.
Environmental science & technology 20050615
-
Electrospray ionization mass and tandem mass spectra of a series of N-pyrazolylmethyl and N-triazolylmethyl N-phenylpiperazines: new dopaminergic ligands with potential antipsychotic properties.
Journal of mass spectrometry : JMS 20050601
-
Prediction of genotoxicity of chemical compounds by statistical learning methods.
Chemical research in toxicology 20050601
-
Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.
Journal of medicinal chemistry 20050407
-
Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys.
Drug and alcohol dependence 20050214
-
Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.
Bioorganic & medicinal chemistry 20050103
-
Interaction of arylpiperazines with the dopamine receptor D2 binding site.
Arzneimittel-Forschung 20050101
-
Synthesis and 5-HT1A/5-HT2A activity of some butyl analogs in the group of phenylpiperazine alkyl pyrimido[2,1-f]theophyllines.
Pharmacological reports : PR 20050101
-
Synthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of 4-phenyl-piperazine.
Farmaco (Societa chimica italiana : 1989) 20050101
-
Comorbidity issues in the pharmacological treatment of Pathological Gambling: a critical review.
Clinical practice and epidemiology in mental health : CP & EMH 20050101
-
Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison.
Molecular diversity 20050101
-
Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.
European journal of medicinal chemistry 20041201
-
Acute psychosis following ingestion of 'Rapture'.
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists 20041201
-
Synthesis of novel N-alkyl carbamates of a-substituted amides of g-hydroxybutyric acid as potential acetylcholinesterase inhibitors.
Acta poloniae pharmaceutica 20041201
-
Electrophoretic behavior and pKa determination of quinolones with a piperazinyl substituent by capillary zone electrophoresis.
Journal of chromatography. A 20041008
-
Modeling of the D2 dopamine receptor arylpiperazine binding site for 1-[2-[5-(1H-benzimidazole-2-thione)]ethyl]-4-arylpiperazines.
Archiv der Pharmazie 20040901
-
New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of 'THIQ'.
Journal of medicinal chemistry 20040826
-
Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype.
Bioorganic & medicinal chemistry letters 20040802
-
Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.
Therapeutic drug monitoring 20040801
-
Phenylpiperazinylmethylheterocycle derivatives: synthesis and dopamine receptor binding profiles.
Archiv der Pharmazie 20040701
-
1- and 2-substituted naphthalenes: a new class of potential hypotensive agents.
Bioorganic & medicinal chemistry letters 20040607
-
Discovery of a potent and selective alpha v beta 3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model.
Bioorganic & medicinal chemistry letters 20040517
-
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.
Journal of medicinal chemistry 20040422
-
Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor.
Journal of medicinal chemistry 20040408
-
Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor.
European journal of medicinal chemistry 20040401
-
Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis.
Therapeutic drug monitoring 20040401
-
Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion.
Bioorganic & medicinal chemistry 20040315
-
Ruthenium-catalyzed anti-Markovnikov hydroamination of vinylarenes.
Journal of the American Chemical Society 20040310
-
Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20040301
-
Discovery of transdermal penetration enhancers by high-throughput screening.
Nature biotechnology 20040201
-
Validated HPLC method for determination of LASSBio-581, a new heterocyclic N-phenylpiperazine derivative, in rat plasma.
Journal of pharmaceutical and biomedical analysis 20031204
-
Intermolecular, markovnikov hydroamination of vinylarenes with alkylamines.
Journal of the American Chemical Society 20031126
-
Aryl piperazine melanocortin MC4 receptor agonists.
Bioorganic & medicinal chemistry letters 20031103
-
Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity.
Bioorganic & medicinal chemistry 20031001
-
New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.
Journal of medicinal chemistry 20030703
-
Rhodium-catalyzed anti-Markovnikov hydroamination of vinylarenes.
Journal of the American Chemical Society 20030514
-
Dopaminergic profile of new heterocyclic N-phenylpiperazine derivatives.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20030501
-
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
Journal of medicinal chemistry 20030410
-
A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy.
Canadian journal of psychiatry. Revue canadienne de psychiatrie 20030301
-
Effects of nefazodone on voluntary ethanol consumption induced by isolation stress in young and aged rats.
Pharmacology, biochemistry, and behavior 20021001
-
Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.
Journal of medicinal chemistry 20020815
-
Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.
Pharmacology, biochemistry, and behavior 20020401
-
Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes.
Chemical & pharmaceutical bulletin 20020401
-
Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity.
European journal of medicinal chemistry 20020301
-
Central nervous system activity of new pyrimidine-8-on[2,1-f]theophylline-9-alkylcarboxylic acids derivatives.
Polish journal of pharmacology 20020101
-
Investigation of mixed D2/5-HT1A activity of N-heteroarylmethyl-N-phenylpiperazines, N-heteroarylethyl-N-phenylpiperazines and N-heteroarylpropyl-N-phenylpiperazines.
Die Pharmazie 20011001
-
Quantitative structure-activity relationship study of novel alpha1a-selective adrenoceptor antagonists.
Journal of enzyme inhibition 20011001
-
1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2).
Bioorganic & medicinal chemistry letters 20010723
-
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.
Bioorganic & medicinal chemistry 20010501
-
Cytotoxic activity of 2-aminomethylene-3(2H)-benzofuranones against human oral tumor cell lines.
Anticancer research 20010101
-
Synthesis, 5-HT1A and 5-HT2A receptor activity of new 1-phenylpiperazinylpropyl derivatives with arylalkyl substituents in position 7 of purine-2,6-dione.
Polish journal of pharmacology 20010101
-
Arylpiperazine derivatives of 3-propyl-beta-tetralonohydantoin as new 5-HT1A and 5-HT2A receptor ligands.
Polish journal of pharmacology 20010101