92-67-1 | 4-Aminobiphenyl

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$25.00	$18.00
5g	97%	in stock	$53.00	$37.00
25g	97%	in stock	$137.00	$96.00
100g	97%	in stock	$406.00	$284.00

Description

• Catalog Number: AB47318
• Chemical Name: 4-Aminobiphenyl
• CAS Number: 92-67-1
• Molecular Formula: C12H11N
• Molecular Weight: 169.2224
• MDL Number: MFCD00007879
• SMILES: Nc1ccc(cc1)c1ccccc1
• NSC Number: 7660

Computed Properties

• Complexity: 141
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2.9

Literature

• Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation.

  Toxicology letters 20180201

• Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens.

  Archives of toxicology 20170901

• Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes.

  Archives of toxicology 20170701

• Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.

  Toxicology 20161212

• Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate.

  Toxicology 20160701

• Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites.

  Archives of toxicology 20151201

• N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer.

  Toxicological sciences : an official journal of the Society of Toxicology 20150401

• MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells.

  Toxicology 20140801

• DNA adducts of the tobacco carcinogens 2-amino-9H-pyrido[2,3-b]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes.

  Chemical research in toxicology 20130916

• Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1.

  Chemical research in toxicology 20130617

• Selective expression of CYP2A13 in human pancreatic α-islet cells.

  Drug metabolism and disposition: the biological fate of chemicals 20121001

• Binary and ternary binding affinities between exonuclease-deficient Klenow fragment (Kf-exo(-)) and various arylamine DNA lesions characterized by surface plasmon resonance.

  Chemical research in toxicology 20120820

• NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.

  Molecular carcinogenesis 20120801

• Effect of ionic liquid on the determination of aromatic amines as contaminants in hair dyes by liquid chromatography coupled to electrochemical detection.

  Molecules (Basel, Switzerland) 20120702

• Personal hair dye use and the risk of bladder cancer: a case-control study from The Netherlands.

  Cancer causes & control : CCC 20120701

• Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver.

  Environmental and molecular mutagenesis 20120601

• Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.

  Cancer letters 20120528

• Incidence of bladder cancer in sri lanka: analysis of the cancer registry data and review of the incidence of bladder cancer in the South asian population.

  Korean journal of urology 20120501

• Rationally designing safer anilines: the challenging case of 4-aminobiphenyls.

  Journal of medicinal chemistry 20120426

• Acquired immunogenicity of human DNA damaged by N-hydroxy-N-acetyl-4-aminobiphenyl.

  IUBMB life 20120401

• Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies.

  Critical reviews in toxicology 20120301

• Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice.

  Cancer prevention research (Philadelphia, Pa.) 20120201

• Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.

  Carcinogenesis 20120201

• Phenotype of the most common 'slow acetylator' arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent.

  Drug metabolism and disposition: the biological fate of chemicals 20120101

• DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry.

  Carcinogenesis 20120101

• Text mining for literature review and knowledge discovery in cancer risk assessment and research.

  PloS one 20120101

• Paraphenylene diamine poisoning.

  Indian journal of pharmacology 20120101

• Haptotropic rearrangement in tricarbonylchromium complexes of 2-aminobiphenyl and 4-aminobiphenyl.

  Dalton transactions (Cambridge, England : 2003) 20111007

• Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational study.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110701

• Polycyclic aromatic hydrocarbon (PAH) exposure and DNA adduct semi-quantitation in archived human tissues.

  International journal of environmental research and public health 20110701

• A current global view of environmental and occupational cancers.

  Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews 20110701

• DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.

  Chemical research in toxicology 20110620

• Urinary pH, cigarette smoking and bladder cancer risk.

  Carcinogenesis 20110601

• Individual variability in the detoxification of carcinogenic arylhydroxylamines in human breast.

  Toxicological sciences : an official journal of the Society of Toxicology 20110601

• Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention.

  Cancer research 20110601

• Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice.

  Drug metabolism and disposition: the biological fate of chemicals 20110501

• Analysis of 4-aminobiphenyl in smoker's and nonsmoker's urine by tandem mass spectrometry.

  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110501

• Revised mechanism of Boyland-Sims oxidation.

  The journal of physical chemistry. A 20110421

• Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A.

  Critical reviews in toxicology 20110401

• Molecular changes in the esophageal epithelium after a subchronic exposure to cigarette smoke in the presence of bile-acid reflux.

  Inhalation toxicology 20110401

• Possible roles of excess tryptophan metabolites in cancer.

  Environmental and molecular mutagenesis 20110301

• DNA adducts of ortho-toluidine in human bladder.

  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110301

• Determination of 2,5-toluylenediamine (2,5-TDA) and aromatic amines in urine after personal application of hair dyes: kinetics and doses.

  Archives of toxicology 20110201

• Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.

  Bioorganic & medicinal chemistry 20110101

• Mechanisms of oxidative DNA damage induced by carcinogenic arylamines.

  Frontiers in bioscience (Landmark edition) 20110101

• Knowns and unknowns on burden of disease due to chemicals: a systematic review.

  Environmental health : a global access science source 20110101

• The effect of tobacco, XPC, ERCC2 and ERCC5 genetic variants in bladder cancer development.

  BMC cancer 20110101

• Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis.

  PloS one 20110101

• The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies.

  Journal of carcinogenesis 20110101

• Polonium and lung cancer.

  Journal of oncology 20110101

• 4-Aminobiphenyl.

  Report on carcinogens : carcinogen profiles 20110101

• Pathobiology and chemoprevention of bladder cancer.

  Journal of oncology 20110101

• Identification of gene expression signature modulated by nicotinamide in a mouse bladder cancer model.

  PloS one 20110101

• Cadmium alters the biotransformation of carcinogenic aromatic amines by arylamine N-acetyltransferase xenobiotic-metabolizing enzymes: molecular, cellular, and in vivo studies.

  Environmental health perspectives 20101201

• Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues.

  Carcinogenesis 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Characterization of the 4-(benzothiazol-2-yl)phenylnitrenium ion from a putative metabolite of a model antitumor drug.

  The Journal of organic chemistry 20100806

• Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.

  The Journal of pharmacology and experimental therapeutics 20100801

• Biomonitoring of smoke constituents: exposure to 4-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in nonsmokers and smokers.

  Inhalation toxicology 20100801

• Determination of aromatic amines in environmental water sample by hollow fiber-liquid phase microextraction and microemulsion electrokinetic chromatography.

  Journal of chromatography. A 20100625

• An improved liquid chromatography-tandem mass spectrometry method for the quantification of 4-aminobiphenyl DNA adducts in urinary bladder cells and tissues.

  Journal of chromatography. A 20100618

• Induction of lacZ mutations in MutaMouse primary hepatocytes.

  Environmental and molecular mutagenesis 20100501

• Bladder cancer among hairdressers: a meta-analysis.

  Occupational and environmental medicine 20100501

• Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice.

  Environmental and molecular mutagenesis 20100301

• Enthalpy-entropy contribution to carcinogen-induced DNA conformational heterogeneity.

  Biochemistry 20100119

• Monocyclic aromatic amines as potential human carcinogens: old is new again.

  Carcinogenesis 20100101

• Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts.

  Cancer cell international 20100101

• Adaptive regression modeling of biomarkers of potential harm in a population of U.S. adult cigarette smokers and nonsmokers.

  BMC medical research methodology 20100101

• Analysis of 4-aminobiphenyl hemoglobin adducts in smokers and nonsmokers by pseudo capillary on-column gas chromatography- tandem mass spectrometry.

  Journal of analytical toxicology 20100101

• Formation and repair of tobacco carcinogen-derived bulky DNA adducts.

  Journal of nucleic acids 20100101

• Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.

  Mutation research 20091201

• Does rapid metabolism ensure negligible risk from bisphenol A?

  Environmental health perspectives 20091101

• Prenatal and early, but not late, postnatal exposure of mice to sidestream tobacco smoke increases airway hyperresponsiveness later in life.

  Environmental health perspectives 20090901

• Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans.

  Molecular carcinogenesis 20090801

• Effects of ethanol and phenobarbital on hemoglobin adducts formation in rats exposed to benzidine and Direct Black 38.

  Industrial health 20090801

• Arylamine N-acetyltransferase activity in bronchial epithelial cells and its inhibition by cellular oxidants.

  Toxicology and applied pharmacology 20090501

• Effect of N7-protonated purine nucleosides on formation of C8 adducts in carcinogenic reactions of arylnitrenium ions with purine nucleosides: a quantum chemistry study.

  The journal of physical chemistry. B 20090423

• Secondhand smoking, 4-aminobiphenyl, and bladder cancer: two meta-analyses.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090401

• Detoxification of benzidine-based azo dye by E. gallinarum: time-course study.

  Ecotoxicology and environmental safety 20090301

• Bacterial reduction in genotoxicity of Direct Red 28 dye.

  Chemosphere 20090301

• Biomarkers of induced active and passive smoking damage.

  International journal of environmental research and public health 20090301

• Screening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometer.

  Analytical chemistry 20090115

• 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20090101

• Development of estimates of dietary nitrates, nitrites, and nitrosamines for use with the Short Willet Food Frequency Questionnaire.

  Nutrition journal 20090101

• Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20081201

• Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.

  Drug metabolism and disposition: the biological fate of chemicals 20081201

• Synergism of aromatic amines and benzo[a]pyrene in induction of Ah receptor-dependent genes.

  Archives of toxicology 20081201

• Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.

  Interdisciplinary toxicology 20081201

• Reaction of the 4-biphenylnitrenium ion with 4-biphenyl azide to produce a 4,4'-azobisbiphenyl stable product: a time-resolved resonance Raman and density functional theory study.

  The journal of physical chemistry. A 20081120

• Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study.

  The British journal of nutrition 20080901

• Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system.

  The Journal of steroid biochemistry and molecular biology 20080901

• Biological decolourization of C.I. Direct Black 38 by E. gallinarum.

  Journal of hazardous materials 20080830

• The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack.

  Journal of ethnopharmacology 20080723

• A 12-month, randomized, controlled study to evaluate exposure and cardiovascular risk factors in adult smokers switching from conventional cigarettes to a second-generation electrically heated cigarette smoking system.

  Journal of clinical pharmacology 20080501

• DNA-directed synthesis of aniline and 4-aminobiphenyl oligomers: programmed transfer of sequence information to a conjoined polymer nanowire.

  Journal of the American Chemical Society 20080312

• Azoreductase and dye detoxification activities of Bacillus velezensis strain AB.

  Applied microbiology and biotechnology 20080101

• Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells.

  BMC cancer 20080101

• Modeling mechanisms of unusual benzene imine n6 adduct formation in carcinogenic reactions of arylnitrenium ions with adenosine.

  The Journal of organic chemistry 20071221

• Voltammetric determination of aminobiphenyls at a boron-doped nanocrystalline diamond film electrode.

  Talanta 20071215

• The metabolic activation of 2-aminofluorine, 4-aminobiphenyl, and benzidine by cytochrome P-450-107S1 of Pseudomonas aeruginosa.

  Toxicology in vitro : an international journal published in association with BIBRA 20071201

• Carcinogen-induced histone alteration in normal human mammary epithelial cells.

  Carcinogenesis 20071001

• Enhanced mutagenesis of Salmonella tester strains due to deletion of genes other than uvrB.

  Environmental and molecular mutagenesis 20071001

• The challenge of testing chemicals for potential carcinogenicity using multiple short-term assays: an analysis of a proposed test battery for hair dyes.

  Mutation research 20070901

• Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells.

  Archives of biochemistry and biophysics 20070815

• Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells.

  Cancer research 20070801

• Environmental tobacco smoke and bladder cancer risk in never smokers of Los Angeles County.

  Cancer research 20070801

• Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species.

  Environmental and molecular mutagenesis 20070601

• Cigarette smoke toxicants as substrates and inhibitors for human cytosolic SULTs.

  Toxicology and applied pharmacology 20070515

• Kinetics of decolourisation and biotransformation of direct black 38 by C. hominis and P. stutzeri.

  Applied microbiology and biotechnology 20070401

• CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline.

  Drug metabolism and disposition: the biological fate of chemicals 20070301

• Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients.

  Carcinogenesis 20070201

• Hemoglobin adducts of the human bladder carcinogen o-toluidine after treatment with the local anesthetic prilocaine.

  Toxicology 20070105

• Proteome characterization of a human urothelial cell line resistant to the bladder carcinogen 4-aminobiphenyl.

  Proteome science 20070101

• Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.

  BMC medical genetics 20070101

• Synthesis of C8-modified 2''-deoxyadenosine with carcinogenic arylamines.

  Nucleosides, nucleotides & nucleic acids 20070101

• Determination of tobacco specific hemoglobin adducts in smoking mothers and new born babies by mass spectrometry.

  Biomarker insights 20070101

• Synthesis and properties of oligonucleotides containing C8-deoxyguanosine arylamine adducts of borderline carcinogens.

  The Journal of organic chemistry 20061222

• CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl.

  International journal of cancer 20061201

• A comparison of nicotine dose estimates in smokers between filter analysis, salivary cotinine, and urinary excretion of nicotine metabolites.

  Psychopharmacology 20061201

• N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice.

  The Journal of pharmacology and experimental therapeutics 20061101

• Early events in the photochemistry of aryl azides from femtosecond UV/Vis spectroscopy and quantum chemical calculations.

  Journal of the American Chemical Society 20061018

• NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity.

  Journal of molecular biology 20061013

• In vivo and in vitro metabolism of arylamine procarcinogens in acetyltransferase-deficient mice.

  Drug metabolism and disposition: the biological fate of chemicals 20061001

• Identification and characterization of functional rat arylamine N-acetyltransferase 3: comparisons with rat arylamine N-acetyltransferases 1 and 2.

  The Journal of pharmacology and experimental therapeutics 20061001

• Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5.

  Chemical research in toxicology 20061001

• Quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human lymphoblastoid TK6 cells dosed with N-hydroxy-4-acetylaminobiphenyl and their relationship to mutation, toxicity, and gene expression profiling.

  Analytical chemistry 20060915

• Effect of N-glucuronidation on urinary bladder genotoxicity of 4-aminobiphenyl in male and female mice.

  Environmental toxicology and pharmacology 20060901

• Hemoglobin adducts in workers exposed to benzidine and azo dyes.

  Carcinogenesis 20060801

• DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice.

  Chemical research in toxicology 20060801

• CYP1A2 and NAT2 phenotyping and 3-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in smokers and non-smokers.

  Toxicology and applied pharmacology 20060615

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Impact of Cyp1a2 or Ahr gene knockout in mice: implications for biomonitoring studies.

  Toxicology letters 20060410

• Metabolic activation of bladder procarcinogens, 2-aminofluorene, 4-aminobiphenyl, and benzidine by Pseudomonas aeruginosa and other human endogenous bacteria.

  Toxicology in vitro : an international journal published in association with BIBRA 20060401

• Tissue distribution of N-acetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster.

  Molecular carcinogenesis 20060401

• Determination of three carcinogenic aromatic amines in urine of smokers and nonsmokers.

  Journal of analytical toxicology 20060401

• Decolorisation, biodegradation and detoxification of benzidine based azo dye.

  Bioresource technology 20060201

• 2- and 4-Aminobiphenyls induce oxidative DNA damage in human hepatoma (Hep G2) cells via different mechanisms.

  Mutation research 20060129

• NAT2 slow acetylation and bladder cancer in workers exposed to benzidine.

  International journal of cancer 20060101

• Levels of H-ras codon 61 CAA to AAA mutation: response to 4-ABP-treatment and Pms2-deficiency.

  Mutagenesis 20060101

• Municipal distribution of bladder cancer mortality in Spain: possible role of mining and industry.

  BMC public health 20060101

• 4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction conditions and characterization of the UDP-glucuronosyltransferase isoforms.

  Journal of applied toxicology : JAT 20060101

• 4-Aminobiphenyl and DNA reactivity: case study within the context of the 2006 IPCS Human Relevance Framework for Analysis of a cancer mode of action for humans.

  Critical reviews in toxicology 20060101

• Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity.

  The Journal of pharmacology and experimental therapeutics 20051201

• 4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice.

  International journal of cancer 20051101

• The direct detection of an aryl azide excited state: an ultrafast study of the photochemistry of para- and ortho-biphenyl azide.

  Journal of the American Chemical Society 20051012

• Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes.

  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20051001

• 4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European Prospective Investigation into Cancer and Nutrition prospective study.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050901

• A modified host cell reactivation assay to measure DNA repair capacity for removing 4-aminobiphenyl adducts: a pilot study of bladder cancer.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050701

• High-performance liquid chromatography method for determination of N-glucuronidation of 4-aminobiphenyl by mouse, rat, and human liver microsomes.

  Analytical biochemistry 20050515

• Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines.

  Mutagenesis 20050501

• Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development.

  Molecular carcinogenesis 20050401

• Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity.

  Chemical research in toxicology 20050401

• Detection and quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human pancreas tissue using capillary liquid chromatography-microelectrospray mass spectrometry.

  Chemical research in toxicology 20050401

• Racial differences in exposure to environmental tobacco smoke among children.

  Environmental health perspectives 20050301

• Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenic model.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050215

• Gene expression profiling of chemically induced rat mammary gland cancer.

  Carcinogenesis 20050201

• Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes.

  Chemical research in toxicology 20050201

• The relationship between antioxidant enzymes and bladder cancer.

  Neoplasma 20050101

• XRCC1 and XPD genetic polymorphisms, smoking and breast cancer risk in a Finnish case-control study.

  Breast cancer research : BCR 20050101

• Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.

  Toxicologic pathology 20050101

• Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro.

  Cancer letters 20041208

• Lactoperoxidase-catalyzed activation of carcinogenic aromatic and heterocyclic amines.

  Chemical research in toxicology 20041201

• Listing occupational carcinogens.

  Environmental health perspectives 20041101

• Alkylaniline-hemoglobin adducts and risk of non-smoking-related bladder cancer.

  Journal of the National Cancer Institute 20041006

• Analysis of the involvement of human N-acetyltransferase 1 in the genotoxic activation of bladder carcinogenic arylamines using a SOS/umu assay system.

  Mutation research 20041004

• Chemical and enzymatic interactions of Direct Black 38 and Direct Brown 1 on release of carcinogenic amines.

  Chemosphere 20040901

• Static and dynamic model for 4-aminodiphenyl fluorescence quenching by carbontetrachloride in hexane.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040701

• Generation and trapping of the 4-biphenylyloxenium ion by water and azide: comparisons with the 4-biphenylylnitrenium ion.

  Journal of the American Chemical Society 20040630

• Carotenoids/vitamin C and smoking-related bladder cancer.

  International journal of cancer 20040620

• Ecotoxicological evaluation of 4-aminobiphenyl using a test battery.

  Ecotoxicology and environmental safety 20040501

• Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines.

  Chemical research in toxicology 20040401

• Modulation of rat and human cytochromes P450 involved in PhIP and 4-ABP activation by an aqueous extract of Phyllanthus orbicularis.

  Journal of ethnopharmacology 20040201

• Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.

  Journal of medicinal chemistry 20040101

• Effects of 'second-hand' smoke on structure and function of fibroblasts, cells that are critical for tissue repair and remodeling.

  BMC cell biology 20040101

• 4-Aminobiphenyl.

  Report on carcinogens : carcinogen profiles 20040101

• Heat shock proteins hsp32 and hsp70 as biomarkers of an early response? In vitro induction of heat shock proteins after exposure of cell culture to carcinogenic compounds and their real mixtures.

  Mutation research 20031209

• Identification of DNA adducts using HPLC/MS/MS following in vitro and in vivo experiments with arylamines and nitroarenes.

  Chemical research in toxicology 20031001

• Identification of aminobiphenyl derivatives in commercial hair dyes.

  Chemical research in toxicology 20030901

• 4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice.

  Journal of the National Cancer Institute 20030820

• Towards direct correlations between spin-crossover and structural features in iron(II) complexes.

  Acta crystallographica. Section B, Structural science 20030801

• The effects of genetic variation in N-acetyltransferases on 4-aminobiphenyl genotoxicity in mouse liver.

  Chemico-biological interactions 20030725

• Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity.

  Toxicological sciences : an official journal of the Society of Toxicology 20030601

• Nonsmoking-related arylamine exposure and bladder cancer risk.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030601

• Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes.

  International journal of hygiene and environmental health 20030601

• The article of Shertzer et al. (2002) has several short comings.

  Toxicology and applied pharmacology 20030501

• Growth inhibition of intestinal bacteria and mutagenicity of 2-, 3-, 4-aminobiphenyls, benzidine, and biphenyl.

  Toxicology in vitro : an international journal published in association with BIBRA 20030401

• Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: the influence of tobacco smoke.

  Carcinogenesis 20030401

• Prenatal expression of N-acetyltransferases in C57Bl/6 mice.

  Chemico-biological interactions 20030306

• Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster.

  Pharmacogenetics 20030301

• Synergic and competitive inhibition effect between two kinds of arylamines in the formation of hemoglobin adduct in vitro.

  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20030201

• Mutant spectra analysis at hisG46 in Salmonella typhimurium strain YG1029 induced by mammalian S9- and plant-activated aromatic amines.

  Teratogenesis, carcinogenesis, and mutagenesis 20030101

• Analysis of aromatic amines in cigarette smoke.

  Rapid communications in mass spectrometry : RCM 20030101

• Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population.

  International journal of cancer 20021201

• Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse.

  Cancer letters 20021108

• Simultaneous determination of various aromatic amines and metabolites of aromatic nitro compounds in urine for low level exposure using gas chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021005

• Semiconductor-mediated photocatalysed degradation of two selected priority organic pollutants, benzidine and 1,2-diphenylhydrazine, in aqueous suspension.

  Chemosphere 20021001

• 4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene.

  Carcinogenesis 20021001

• Biodegradation of benzidine based azodyes Direct red and Direct blue by the immobilized cells of Pseudomonas fluorescens D41.

  Indian journal of experimental biology 20021001

• Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue-specific carcinogenic activity.

  Toxicology 20020930

• Effects of lead on 4-aminobiphenyl pharmacokinetics in liver, kidney, spleen, testes, heart, lung and hemoglobin adduct for rat model.

  Ecotoxicology (London, England) 20020801

• A myeloperoxidase polymorphism associated with reduced risk of lung cancer.

  Lung cancer (Amsterdam, Netherlands) 20020701

• Oxidative DNA damage induced by a metabolite of 2-naphthylamine, a smoking-related bladder carcinogen.

  Japanese journal of cancer research : Gann 20020701

• Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.

  Biological chemistry 20020601

• Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice.

  Toxicology and applied pharmacology 20020515

• The role of metals in site-specific DNA damage with reference to carcinogenesis.

  Free radical biology & medicine 20020501

• Determinants of 4-aminobiphenyl-DNA adducts in bladder cancer biopsies.

  Carcinogenesis 20020501

• Determination of hemoglobin adducts formed in rats exposed orally with 3,3'-dichlorobenzidine by GC/MS-SIM.

  Toxicology and industrial health 20020501

• Transformation of mutagenic aromatic amines into non-mutagenic species by alkyl substituents. Part II: alkylation far away from the amino function.

  Mutation research 20020325

• N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20020301

• [Respiratory diseases and genotoxicity in tobacco smoke exposed children].

  Laryngo- rhino- otologie 20020301

• Identification of new DNA adducts in human bladder epithelia exposed to the proximate metabolite of 4-aminobiphenyl using 32P-postlabeling method.

  Chemico-biological interactions 20020220

• Analysis of arylamine isomers by micellar electrokinetic chromatography.

  Electrophoresis 20020201

• Human urinary bladder epithelial cells lacking wild-type p53 function are deficient in the repair of 4-aminobiphenyl-DNA adducts in genomic DNA.

  Mutation research 20020129

• Tobacco smoke carcinogens and breast cancer.

  Environmental and molecular mutagenesis 20020101

• Evidence for the presence of mutagenic arylamines in human breast milk and DNA adducts in exfoliated breast ductal epithelial cells.

  Environmental and molecular mutagenesis 20020101

• Carcinogen-DNA adducts in human breast epithelial cells.

  Environmental and molecular mutagenesis 20020101

• Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition.

  Cancer detection and prevention 20020101

• Identification of N-(deoxyguanosin-8-yl)-4-azobiphenyl by (32)P-postlabeling analyses of DNA in human uroepithelial cells exposed to proximate metabolites of the environmental carcinogen 4-aminobiphenyl.

  Environmental and molecular mutagenesis 20020101

• The effect of the trolox equivalent antioxidant capacity (TEAC) in plasma on the formation of 4-aminobiphenylhaemoglobin adducts in smokers.

  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20020101

• 4-Aminobiphenyl.

  Report on carcinogens : carcinogen profiles 20020101

• Mutagenic outcome of the urinary carcinogen 4-aminobiphenyl is increased in acidic pH.

  Environmental toxicology and pharmacology 20020101

• Synthesis of C8-adenosine adducts of arylamines using palladium catalysis.

  Organic letters 20011227

• Using base-specific Salmonella tester strains to characterize the types of mutation induced by benzidine and benzidine congeners after reductive metabolism.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20011201

• Transient-resonance Raman and density functional theory investigation of 4-biphenylylnitrenium, 2-fluorenylnitrenium, and diphenylnitrenium ions.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20011119

• Transformation of mutagenic aromatic amines into non-mutagenic species by alkyl substituents. Part I. Alkylation ortho to the amino function.

  Mutation research 20011115

• In vivo inhibition of multivitamin on the formation of hemoglobin adduct in 4-aminobiphenyl-treated rat.

  Bulletin of environmental contamination and toxicology 20011101

• Biological monitoring in workers in a nitrobenzene reduction plant: haemoglobin versus serum albumin adducts.

  International archives of occupational and environmental health 20010901

• Haemoglobin adducts from aromatic amines in children in relation to area of residence and exposure to environmental tobacco smoke.

  International archives of occupational and environmental health 20010801

• The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats.

  Mutagenesis 20010701

• Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice.

  Mutation research 20010602

• High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5'-diphosphate-glucuronosyltransferase.

  Analytical biochemistry 20010515

• Gender- and smoking-related bladder cancer risk.

  Journal of the National Cancer Institute 20010404

• Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.

  Free radical biology & medicine 20010401

• Determination of the levels of aromatic amines in indoor and outdoor air in Italy.

  Chemosphere 20010401

• The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis.

  Toxicology letters 20010331

• Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.

  Cancer research 20010315

• Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects.

  Pharmacogenetics 20010201

• Carcinogen substrate specificity of human COX-1 and COX-2.

  Carcinogenesis 20010101

• DNA damage in human transitional cell carcinoma cells after exposure to the proximate metabolite of the bladder carcinogen 4-aminobiphenyl.

  Environmental and molecular mutagenesis 20010101

• Epidemiology and etiology of premalignant and malignant urothelial changes.

  Scandinavian journal of urology and nephrology. Supplementum 20000101

• Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation.

  Mutation research 19970801

• Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

  Cancer research 19890615

• Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases.

  Cancer research 19890101

• Specificity study to evaluate induction of aberrant crypts in murine colons.

  Cancer research 19881101

• Increased agglutinability of bladder epithelial cells by concanavalin A in rats fed several biphenyl derivatives.

  Journal of cancer research and clinical oncology 19830101