926037-48-1 | Radotinib

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$13.00	$9.00
5mg	98%	in stock	$23.00	$17.00
10mg	98%	in stock	$32.00	$22.00
50mg	98%	in stock	$60.00	$42.00
100mg	98%	in stock	$108.00	$76.00
250mg	98%	in stock	$173.00	$121.00
1g	98%	in stock	$467.00	$327.00
5g	98%	in stock	$2,268.00	$1,587.00

Description

• Catalog Number: AH94945
• Chemical Name: Radotinib
• CAS Number: 926037-48-1
• Molecular Formula: C27H21F3N8O
• Molecular Weight: 530.5038496000001
• MDL Number: MFCD27956910
• SMILES: Cc1ncn(c1)c1cc(NC(=O)c2ccc(c(c2)Nc2nccc(n2)c2nccnc2)C)cc(c1)C(F)(F)F

Computed Properties

• Complexity: 818
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 3.9

Literature

• Radotinib is an effective inhibitor of native and kinase domain-mutant BCR-ABL1.

  Leukemia 20150901

• Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors.

  Haematologica 20140701

• Pushing the limits of targeted therapy in chronic myeloid leukaemia.

  Nature reviews. Cancer 20120724