93-35-6 | 7-Hydroxycoumarin

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$10.00	$7.00
10g	97%	in stock	$15.00	$10.00
25g	97%	in stock	$29.00	$20.00
100g	97%	in stock	$80.00	$56.00

Description

• Catalog Number: AB80295
• Chemical Name: 7-Hydroxycoumarin
• CAS Number: 93-35-6
• Molecular Formula: C9H6O3
• Molecular Weight: 162.14214000000004
• MDL Number: MFCD00014738
• SMILES: Oc1ccc2c(c1)oc(=O)cc2
• NSC Number: 19790

Computed Properties

• Complexity: 222
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.6

Literature

• Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via activation of Nrf2.

  Chemico-biological interactions 20171001

• Protective Effects of 7-Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol-Induced Myocardial Infarction in Rats.

  Journal of biochemical and molecular toxicology 20160301

• Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice.

  Chemico-biological interactions 20140605

• Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris.

  Fitoterapia 20140601

• 7-Hydroxycoumarin modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils.

  Chemico-biological interactions 20131025

• Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.

  Journal of applied toxicology : JAT 20130201

• Synthesis and biological evaluation of coumarin derivatives as inhibitors of Mycobacterium bovis (BCG).

  Chemical biology & drug design 20121201

• Effect of colloidal silica on the spectral behaviour of 7-hydroxycoumarin in aqueous medium.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101

• Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva.

  Journal of ethnopharmacology 20121031

• Using smell to triage samples in point-of-care assays.

  Angewandte Chemie (International ed. in English) 20121029

• Uricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic mice.

  Journal of ethnopharmacology 20121011

• Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases.

  Neurotoxicology 20121001

• Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents.

  Molecules (Basel, Switzerland) 20120919

• Synthesis and antibacterial activities of novel 4-hydroxy-7-hydroxy- and 3-carboxycoumarin derivatives.

  Molecules (Basel, Switzerland) 20120910

• Liver protein targets of hepatotoxic 4-bromophenol metabolites.

  Chemical research in toxicology 20120820

• A unique approach to development of near-infrared fluorescent sensors for in vivo imaging.

  Journal of the American Chemical Society 20120815

• Synthesis and anthelmintic activity of osthol analogs against Dactylogyrus intermedius in goldfish.

  European journal of medicinal chemistry 20120801

• Development, validation and application of a sensitive LC-MS/MS method for the quantification of thalidomide in human serum, cells and cell culture medium.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120801

• Quencher-free molecular beacon tethering 7-hydroxycoumarin detects targets through protonation/deprotonation.

  Bioorganic & medicinal chemistry 20120715

• In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist.

  Drug metabolism and disposition: the biological fate of chemicals 20120601

• Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4.

  Drug metabolism and disposition: the biological fate of chemicals 20120601

• Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.

  Archives of pharmacal research 20120601

• A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2'-hydroxylase activity (C2'H): a missing step in the synthesis of umbelliferone in plants.

  The Plant journal : for cell and molecular biology 20120501

• Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial.

  Obesity surgery 20120501

• Tyrosine-like condensed derivatives as tyrosinase inhibitors.

  The Journal of pharmacy and pharmacology 20120501

• Pressurized liquid extraction of coumarins from fruits of Heracleum leskowii with application of solvents with different polarity under increasing temperature.

  Molecules (Basel, Switzerland) 20120405

• [Chemical constituents contained in seeds of Notopterygium franchetii].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401

• New biological activities of Casimiroa edulis leaf extract and isolated compounds.

  Phytotherapy research : PTR 20120301

• [Coumarins from Skimmia arborescens and its anti-inflammatory effect].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301

• A method of hepatocyte extraction conjugated with HPLC is established for screening potential active components in Chinese medicines--probing Herba Artemisiae Scopariae as an exemplifying approach.

  Molecules (Basel, Switzerland) 20120206

• Oxidative modification of rat sulfotransferase 1A1 activity in hepatic tissue slices correlates with effects on the purified enzyme.

  Drug metabolism and disposition: the biological fate of chemicals 20120201

• Molecular cloning and functional analysis of the ortho-hydroxylases of p-coumaroyl coenzyme A/feruloyl coenzyme A involved in formation of umbelliferone and scopoletin in sweet potato, Ipomoea batatas (L.) Lam.

  Phytochemistry 20120201

• Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats.

  Pharmaceutical biology 20120201

• [Fingerprint analysis of Glehniae Radix by TLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120201

• Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

  Bioorganic & medicinal chemistry 20120115

• A new furanocoumarin from the mangrove endophytic fungus Penicillium sp. (ZH16).

  Natural product research 20120101

• Phagocytosis and killing of Salmonella by 7-hydroxycoumarin activated macrophages.

  Immunological investigations 20120101

• The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases.

  Advances in urology 20120101

• TiO2 nanoparticles are phototoxic to marine phytoplankton.

  PloS one 20120101

• In vitro antioxidant and anti-inflammatory activities of Angelica decursiva.

  Archives of pharmacal research 20120101

• Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats.

  Indian journal of pharmacology 20120101

• Immunological response as a source to variability in drug metabolism and transport.

  Frontiers in pharmacology 20120101

• Current approaches toward production of secondary plant metabolites.

  Journal of pharmacy & bioallied sciences 20120101

• A pharmacological appraisal of medicinal plants with antidiabetic potential.

  Journal of pharmacy & bioallied sciences 20120101

• Chemical composition and antioxidant activities of Broussonetia papyrifera fruits.

  PloS one 20120101

• Antioxidant activity of mulberry fruit extracts.

  International journal of molecular sciences 20120101

• Phenolic compounds from the aerial parts of Diplomorpha canescens.

  Chemical & pharmaceutical bulletin 20120101

• Ethnopharmacology of medicinal plants of the pantanal region (mato grosso, Brazil).

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives.

  International journal of molecular sciences 20120101

• Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Implementing best practices and validation of cryopreservation techniques for microorganisms.

  TheScientificWorldJournal 20120101

• Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.

  PloS one 20120101

• Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on lipopolysaccharide/interferon γ-stimulated nitric oxide production in RAW264 cells.

  Biological & pharmaceutical bulletin 20120101

• Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

  Journal of medicinal chemistry 20111222

• Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of β-hematin formation.

  Journal of pharmaceutical and biomedical analysis 20111215

• Umbelliferone modulates gamma-radiation induced reactive oxygen species generation and subsequent oxidative damage in human blood lymphocytes.

  European journal of pharmacology 20111215

• Characteristics and photo-responsive release property of liposome containing 7-acetoxy coumarin.

  Journal of nanoscience and nanotechnology 20111101

• In vitro isolation, elicitation of psoralen in callus cultures of Psoralea corylifolia and cloning of psoralen synthase gene.

  Plant physiology and biochemistry : PPB 20111001

• Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative.

  Bioorganic & medicinal chemistry letters 20111001

• Oxygen therapy improves energy metabolism in focal cerebral ischemia.

  Brain research 20110930

• Structure-guided engineering of a Pacific Blue fluorophore ligase for specific protein imaging in living cells.

  Biochemistry 20110927

• A new coumarin-based fluorescence turn-on chemodosimeter for Cu2+ in water.

  Analytica chimica acta 20110919

• Identification, synthesis and quantification of process-related impurities in auraptene.

  Journal of pharmaceutical and biomedical analysis 20110910

• In vitro antifungal activity of coumarin extracted from Loeselia mexicana Brand.

  Mycoses 20110901

• 1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase.

  Drug metabolism and disposition: the biological fate of chemicals 20110901

• Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives.

  European journal of medicinal chemistry 20110901

• Use of a coumarin-labeled hexa-arginine peptide as a fluorescent hydroxyl radical probe in a nanoparticulate plasmid DNA condensate.

  The journal of physical chemistry. B 20110818

• The use of umbelliferone in the synthesis of new heterocyclic compounds.

  Molecules (Basel, Switzerland) 20110810

• Thiomers: Inhibition of cytochrome P450 activity.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110801

• Paniculacin, a new coumarin derivative from Murraya paniculata.

  Journal of Asian natural products research 20110801

• Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.

  Bioorganic & medicinal chemistry letters 20110715

• Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.

  Journal of natural products 20110624

• A novel and unusually long-lived chemiluminophore based on the 7-hydroxycoumarin scaffold.

  Chemical communications (Cambridge, England) 20110621

• Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity.

  Biotechnology and bioengineering 20110601

• Synthesis and pharmacological activity of O-aminoalkyl derivatives of 7-hydroxycoumarin.

  European journal of medicinal chemistry 20110601

• New halogenated phenylcoumarins as tyrosinase inhibitors.

  Bioorganic & medicinal chemistry letters 20110601

• Novel coumarin-based tyrosinase inhibitors discovered by OECD principles-validated QSAR approach from an enlarged, balanced database.

  Molecular diversity 20110501

• Umbelliferone induces changes in the structure and pharmacological activities of Bn IV, a phospholipase A(2) isoform isolated from Bothrops neuwiedi.

  Toxicon : official journal of the International Society on Toxinology 20110501

• Combination of molluscicides with attractant carbohydrates and amino acids in bait formulation against the snail Lymnaea acuminata.

  European review for medical and pharmacological sciences 20110501

• Dimethyl-ammonium 2-[(2-oxo-2H-chromen-7-yl)-oxy]acetate.

  Acta crystallographica. Section E, Structure reports online 20110501

• Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin.

  Journal of natural products 20110425

• Ratiometric coumarin-neutral red (CONER) nanoprobe for detection of hydroxyl radicals.

  Analytical chemistry 20110401

• Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers.

  Molecular nutrition & food research 20110401

• Lignans and other constituents from aerial parts of Haplophyllum villosum.

  Molecules (Basel, Switzerland) 20110307

• A TD-DFT study on the cyanide-chemosensing mechanism of 8-formyl-7-hydroxycoumarin.

  Journal of computational chemistry 20110301

• Effect of chromium and cobalt ions on phase I and phase II enzymatic activities in vitro in freshly isolated rat hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20110201

• Extraction and identification of three major aldose reductase inhibitors from Artemisia montana.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110201

• Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1.

  Journal of medicinal chemistry 20110113

• On-line HPLC analysis system for metabolism and inhibition studies in precision-cut liver slices.

  Analytical chemistry 20110101

• The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• [Aromatic constituents of Heteroplexis micocephal and their bioactivities].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110101

• A cytochrome P450 monooxygenase commonly used for negative selection in transgenic plants causes growth anomalies by disrupting brassinosteroid signaling.

  BMC plant biology 20110101

• A soluble acetylcholinesterase provides chemical defense against xenobiotics in the pinewood nematode.

  PloS one 20110101

• Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro Studies on A375 Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Phytochemical screening, antioxidant, and antimicrobial activities of the crude leaves' extract from Ipomoea batatas (L.) Lam.

  Pharmacognosy magazine 20110101

• Development of Randomly Amplified Polymorphic DNA Based SCAR Marker for Identification of Ipomoea mauritiana Jacq (Convolvulaceae).

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Exposure to sublethal doses of fipronil and thiacloprid highly increases mortality of honeybees previously infected by Nosema ceranae.

  PloS one 20110101

• Evaluation of the anti-inflammatory activity of Aegle marmelos (Bilwa) root.

  Indian journal of pharmacology 20110101

• Combined 3D-QSAR and docking modelling study on indolocarbazole series compounds as Tie-2 inhibitors.

  International journal of molecular sciences 20110101

• Role of phenolic compounds in peptic ulcer: An overview.

  Journal of pharmacy & bioallied sciences 20110101

• Determination of HX0969w in rabbit whole blood by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.

  European journal of mass spectrometry (Chichester, England) 20110101

• Bait formulations of molluscicides and their effects on biochemical changes in the ovotestis of snail Lymnaea acuminata (Mollusca; Gastropoda:Lymnaeidae).

  Revista do Instituto de Medicina Tropical de Sao Paulo 20110101

• The antioxidant activity of new coumarin derivatives.

  International journal of molecular sciences 20110101

• Structural determinants of CX-4945 derivatives as protein kinase CK2 inhibitors: a computational study.

  International journal of molecular sciences 20110101

• Chamomile (Matricaria chamomilla L.): An overview.

  Pharmacognosy reviews 20110101

• Standardization of sulaharan yoga: an ayurvedic tablet formulation.

  Indian journal of pharmaceutical sciences 20110101

• Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids.

  Indian journal of pharmaceutical sciences 20110101

• Fascioliasis control: in vivo and in vitro phytotherapy of vector snail to kill fasciola larva.

  Journal of parasitology research 20110101

• Effects of Semelil (ANGIPARS™) on diabetic peripheral neuropathy: A randomized, double-blind Placebo-controlled clinical trial.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

• 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.

  Bioorganic & medicinal chemistry letters 20101215

• In vivo indirect measurement of cytochrome P450-associated activities in freshwater gastropod molluscs.

  Environmental toxicology 20101201

• Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats.

  Pharmaceutical biology 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• [Chemical constituents from Hydrangea paniculata].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

• A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices.

  Lab on a chip 20101021

• Molecular cloning and characterization of a novel tomato xylosyltransferase specific for gentisic acid.

  Journal of experimental botany 20101001

• 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.

  Bioorganic & medicinal chemistry letters 20101001

• [Studies on the chemical constituents of Pharbitis purpurea].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101001

• Development and application of UHPLC-MS/MS method for the determination of phenolic compounds in Chamomile flowers and Chamomile tea extracts.

  Talanta 20100915

• Percutaneous absorption and metabolism of [14C]-ethoxycoumarin in a pig ear skin model.

  Toxicology in vitro : an international journal published in association with BIBRA 20100801

• Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum.

  Plant physiology 20100801

• Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.

  Bioorganic & medicinal chemistry letters 20100801

• Magnetic activated release of umbelliferone from lipid matrices.

  International journal of pharmaceutics 20100715

• LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis.

  Plant physiology 20100701

• Antitermite activities of coumarin derivatives and scopoletin from Protium javanicum Burm. f.

  Journal of chemical ecology 20100701

• Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa.

  Chemistry & biodiversity 20100701

• catena-Poly[[[aqua(7-hydroxy-2H-1-benzopyran-2-one)sodium]-di-μ-aqua] 2-oxo-2H-1-benzopyran-7-olate monohydrate].

  Acta crystallographica. Section E, Structure reports online 20100701

• The metabolism and N-oxide reduction of olaquindox in liver preparations of rats, pigs and chicken.

  Toxicology letters 20100519

• [8-[Bis(carboxymethyl)aminomethyl]-6-bromo-7-hydroxycoumarin-4-yl]methyl moieties as photoremovable protecting groups for compounds with COOH, NH2, OH, and C=O functions.

  The Journal of organic chemistry 20100507

• Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.

  Drug metabolism and disposition: the biological fate of chemicals 20100501

• Functional characterization of cytochrome P450 2A6 allelic variants CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22.

  Drug metabolism and disposition: the biological fate of chemicals 20100501

• Structural determination of daphnecin, a new coumarinolignan from Daphne mucronata.

  Journal of Asian natural products research 20100401

• Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion.

  Journal of proteome research 20100305

• Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway.

  Journal of veterinary science 20100301

• Fluorogenic substrates for the screening assay of transketolase through beta-elimination of umbelliferone--Development, scope and limitations.

  Journal of biotechnology 20100215

• Modulation of cytokine production by 7-hydroxycoumarin in vitro and its efficacy against influenza infection in mice.

  Antiviral research 20100201

• Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain.

  The Journal of pharmacy and pharmacology 20100201

• Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships.

  Phytotherapy research : PTR 20100101

• Effects of P-glycoprotein and Mrp2 inhibitors on the hepatobiliary disposition of Rhodamine 123 and its glucuronidated metabolite in isolated perfused rat livers.

  Journal of pharmaceutical sciences 20100101

• Docking and 3D-QSAR studies of 7-hydroxycoumarin derivatives as CK2 inhibitors.

  European journal of medicinal chemistry 20100101

• Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2.

  PloS one 20100101

• Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models.

  Malaria journal 20100101

• Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation.

  BMC complementary and alternative medicine 20100101

• Explaining the atypical reaction profiles of heme enzymes with a novel mechanistic hypothesis and kinetic treatment.

  PloS one 20100101

• Analysis of quinapril by two solvent-saving methods: application of capillary column high-performance liquid chromatography with ultraviolet absorbance detection and LDI-TOF-MS.

  Journal of AOAC International 20100101

• Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene.

  BMC cancer 20100101

• 3D-QSAR and molecular docking studies on fused pyrazoles as p38α mitogen-activated protein kinase inhibitors.

  International journal of molecular sciences 20100101

• Update on treatment of partial onset epilepsy: role of eslicarbazepine.

  Neuropsychiatric disease and treatment 20100101

• Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.

  Journal of ethnobiology and ethnomedicine 20100101

• Small molecule immunosensing using surface plasmon resonance.

  Sensors (Basel, Switzerland) 20100101

• Anethum graveolens: An Indian traditional medicinal herb and spice.

  Pharmacognosy reviews 20100101

• Effect of pomegranate juice pre-treatment on the transport of carbamazepine across rat intestine.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

• Effects of Angipars on oxidative inflammatory indices in a murine model of periodontitis.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

• Formation of coumarines during the degradation of alkyl substituted aromatic oil components by the yeast Trichosporon asahii.

  Applied microbiology and biotechnology 20091001

• A genetically encoded direct sensor of antibody-antigen interactions.

  Chembiochem : a European journal of chemical biology 20090904

• Design and synthesis of coumarin-based Zn(2+) probes for ratiometric fluorescence imaging.

  Inorganic chemistry 20090817

• Antiviral activity of indole derivatives.

  Antiviral research 20090801

• Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model.

  PLoS pathogens 20090801

• Novel coumarin and furan from the roots of Angelica pubescens f. biserrata.

  Journal of Asian natural products research 20090801

• Total synthesis of (+)-angelmarin.

  The Journal of organic chemistry 20090717

• Azo dyes decomposition on new nitrogen-modified anatase TiO2 with high adsorptivity.

  Journal of hazardous materials 20090715

• Tyrosinase inhibitor activity of coumarin-resveratrol hybrids.

  Molecules (Basel, Switzerland) 20090713

• Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS.

  Journal of pharmaceutical and biomedical analysis 20090712

• Probing the binding of 8-Acetyl-7-hydroxycoumarin to human serum albumin by spectroscopic methods and molecular modeling.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090701

• The extent of phase I and phase II reactions is affected by the choice of enzyme used to prepare rat hepatocytes.

  Chemico-biological interactions 20090515

• New 18-l process-scale counter-current chromatography centrifuge.

  Journal of chromatography. A 20090508

• Highly enantioselective total synthesis of (-)-(3'S)-Lomatin and (+)-(3'S,4'R)-trans-khellactone.

  Organic letters 20090507

• Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives.

  European journal of medicinal chemistry 20090501

• Effects of umbelliferone in a murine model of allergic airway inflammation.

  European journal of pharmacology 20090501

• [Coumarins from Peucedanum harry-smithii var. subglabrum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501

• A simple fluorescent probe for the determination of dissolved oxygen based on the catalytic activation of oxygen by iron(II) chelates.

  Analytica chimica acta 20090427

• Evaluation of alternatives to warfarin as probes for Sudlow site I of human serum albumin: characterization by high-performance affinity chromatography.

  Journal of chromatography. A 20090417

• Silkworm as a model animal to evaluate drug candidate toxicity and metabolism.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090401

• Umbelliferone aminoalkyl derivatives as inhibitors of human oxidosqualene-lanosterol cyclase.

  Journal of enzyme inhibition and medicinal chemistry 20090401

• CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking.

  European journal of clinical pharmacology 20090401

• Recombinant expression and functional characterisation of regiospecific flavonoid glucosyltransferases from Hieracium pilosella L.

  Planta 20090401

• Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors.

  Bioorganic & medicinal chemistry 20090315

• Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom.

  Toxicon : official journal of the International Society on Toxinology 20090315

• Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.

  Bioorganic & medicinal chemistry letters 20090215

• Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata.

  Phytotherapy research : PTR 20090201

• Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures.

  Plant cell reports 20090201

• Determination of hydroxyl rate constants by a high-throughput fluorimetric assay: towards a unified reactivity scale for antioxidants.

  The Analyst 20090201

• Metabolism of polybrominated diphenyl ethers (PBDEs) by human hepatocytes in vitro.

  Environmental health perspectives 20090201

• Salicylic acid-induced changes to growth and phenolic metabolism in Matricaria chamomilla plants.

  Plant cell reports 20090101

• Extraction of antioxidants from plants using ultrasonic methods and their antioxidant capacity.

  Journal of separation science 20090101

• The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides.

  PLoS neglected tropical diseases 20090101

• Further studies on the chemical constituents of Chinese folk medicine Gentiana apiata N.E. Br.

  Journal of Asian natural products research 20090101

• Does the clock make the poison? Circadian variation in response to pesticides.

  PloS one 20090101

• Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.

  BMC complementary and alternative medicine 20090101

• Negative ion electrospray ionization mass spectrometry and computational studies on substituted 7-hydroxycoumarins.

  European journal of mass spectrometry (Chichester, England) 20090101

• Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies).

  BMC genomics 20090101

• Antioxidant Activity and Total Phenolic and Flavonoid Contents of Hieracium pilosella L. Extracts.

  Sensors (Basel, Switzerland) 20090101

• Investigation of biosynthetic pathways to hydroxycoumarins during post-harvest physiological deterioration in Cassava roots by using stable isotope labelling.

  Chembiochem : a European journal of chemical biology 20081215

• Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling.

  Toxicology in vitro : an international journal published in association with BIBRA 20081201

• Umbelliferone and esculetin: inhibitors or substrates for polyphenol oxidases?

  Biological & pharmaceutical bulletin 20081201

• Synthesis and free radical scavenging activity of some new spiropyranocoumarins.

  Bioorganic & medicinal chemistry letters 20081101

• 7-hydroxycoumarin-hemicyanine hybrids: a new class of far-red emitting fluorogenic dyes.

  Organic letters 20081002

• [Studies on chemical constituents from Elaeocarpus sylvestris].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081001

• Protective effects of dietary chamomile tea on diabetic complications.

  Journal of agricultural and food chemistry 20080910

• Synthesis and properties of umbelliferone-nitroxide radical hybrid compounds as fluorescence and spin-label probes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080901

• Studies of coumarins from the Chinese drug Qianhu, XXVII: structure of a new simple coumarin glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum.

  Chemical & pharmaceutical bulletin 20080901

• [Study on fluorescent properties of coumarin derivatives and determination of trace iron].

  Guang pu xue yu guang pu fen xi = Guang pu 20080901

• Latent fluorophores based on a self-immolative linker strategy and suitable for protease sensing.

  Bioconjugate chemistry 20080801

• Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency.

  Journal of enzyme inhibition and medicinal chemistry 20080801

• [Studies on chemical constituents of Peucedanum delavayi].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

• Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle.

  Journal of experimental botany 20080701

• Analysis of ciprofloxacin by a simple high-performance liquid chromatography method.

  Journal of chromatographic science 20080701

• A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening.

  Assay and drug development technologies 20080601

• [Studies on chemical constituents of Saussurea laniceps].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• [Study on steroids of Cacalia tangutica].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• [Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080401

• Optimizing glycosyltransferase specificity via 'hot spot' saturation mutagenesis presents a catalyst for novobiocin glycorandomization.

  Chemistry & biology 20080401

• [Studies on chemical constituents of the roots of Angelica pubescens].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080401

• Separation and identification of botanical insecticide 7-hydroxycoumarin and its biological activity against Aphis craccivora and Culex pipiens pallens.

  Natural product research 20080310

• Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae.

  Bioorganic & medicinal chemistry 20080301

• Artemisinin and CYP2A6 activity in healthy subjects.

  European journal of clinical pharmacology 20080301

• Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships.

  Journal of medicinal chemistry 20080227

• Rapid probing of photocatalytic activity on titania-based self-cleaning materials using 7-hydroxycoumarin fluorescent probe.

  Analytica chimica acta 20080204

• Development of micromarkers with various photoluminescence colors as tracers for shadowing pursuits.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080201

• Substrate arrays for fluorescence-based enzyme fingerprinting and high-throughput screening.

  Annals of the New York Academy of Sciences 20080101

• Comparison of the effect of 4-hydroxycoumarin and umbelliferone on the phase transition of dipalmitoylphosphatidylcholine (DPPC) bilayers.

  Pharmacological reports : PR 20080101

• TAC-scaffolded tripeptides as artificial hydrolytic receptors: a combinatorial approach toward esterase mimics.

  Journal of combinatorial chemistry 20080101

• A review of coumarin derivatives in pharmacotherapy of breast cancer.

  Current medicinal chemistry 20080101

• Biosynthetic origin of the 1-oxygen of umbelliferone in the root tissue of sweet potato.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

• In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data.

  Drug metabolism and drug interactions 20080101

• A novel fluorogenic coumarin substrate for monitoring acid phosphatase activity at low pH environment.

  Current chemical genomics 20080101

• [Chemical constituents from roots of Ferula sinkiangensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071101

• Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives.

  Bioorganic & medicinal chemistry letters 20071015

• Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida.

  Journal of ethnopharmacology 20070815

• Rapid densitometric method for simultaneous analysis of umbelliferone, psoralen, and eugenol in herbal raw materials using HPTLC.

  Journal of separation science 20070801

• Effect of umbelliferone on tail tendon collagen and haemostatic function in streptozotocin-diabetic rats.

  Basic & clinical pharmacology & toxicology 20070801

• Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae).

  Journal of ethnopharmacology 20070725

• Protective effect of Umbelliferone on membranous fatty acid composition in streptozotocin-induced diabetic rats.

  European journal of pharmacology 20070702

• Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition.

  European journal of medicinal chemistry 20070701

• Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture.

  Planta medica 20070701

• Capillary electrochromatography of selected phenolic compounds of Chamomilla recutita.

  Journal of chromatography. A 20070622

• The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy.

  Blood 20070601

• Induction of phase I and II drug metabolism in rat small intestine and colon in vitro.

  Drug metabolism and disposition: the biological fate of chemicals 20070601

• Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.

  Fundamental & clinical pharmacology 20070601

• Evaluation of the content and stability of the constituents of mother tinctures and tinctures: the case of Crataegus oxyacantha L. and Hieracium pilosella L.

  Journal of pharmaceutical and biomedical analysis 20070509

• A review of the hepatotoxic plant Lantana camara.

  Critical reviews in toxicology 20070501

• Determination of six bioactive components of Saussurea katochaete by capillary electrophoresis.

  Biomedical chromatography : BMC 20070401

• Fluorogenic substrates for lipases, esterases, and acylases using a TIM-mechanism for signal release.

  Biotechnology journal 20070201

• CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?

  Pharmacogenomics 20070201

• Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis.

  The Journal of biological chemistry 20070105

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• Enhanced resistance to Salmonella enterica serovar Typhimurium infection in mice after coumarin treatment.

  Microbes and infection 20070101

• [Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070101

• Antitumor and immunomodulatory effect of coumarin and 7-hydroxycoumarin against Sarcoma 180 in mice.

  Journal of experimental therapeutics & oncology 20070101

• [Studies on the chemical constituents of the aerial parts of Seseli mairei].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070101

• Influence of umbelliferone on membrane-bound ATPases in streptozotocin-induced diabetic rats.

  Pharmacological reports : PR 20070101

• Phytochemical and antinociceptive properties of Matayba elaeagnoides Radlk. barks.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

• New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents.

  Metal-based drugs 20070101

• Influence of umbelliferone on glycoprotein components in diabetic rats.

  Toxicology mechanisms and methods 20070101

• Tetrapleura tetraptera: molluscicidal activity and chemical constituents.

  African journal of traditional, complementary, and alternative medicines : AJTCAM 20070101

• Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinata.

  Phytochemistry 20061201

• In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.

  Drug metabolism and pharmacokinetics 20061201

• Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus.

  Archives of pharmacal research 20061201

• [Studies on chemical constituents from fruits of Paliurus ramosissimus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.

  PLoS medicine 20061101

• Simultaneous determination of urinary metabolites of methoxypsoralens in human and Umbelliferae medicines by high-performance liquid chromatography.

  Journal of chromatographic science 20060901

• [Tissue-like cultures of rat hepatocytes in study of phase I and phase II drug metabolism].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060901

• Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity.

  Archives of pharmacal research 20060801

• Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers.

  Drug metabolism and disposition: the biological fate of chemicals 20060701

• Interface of AOT/Brij mixed reverse micellar systems: conductometric and spectrophotometric investigations.

  Journal of colloid and interface science 20060615

• Antioxidant role of Umbelliferone in STZ-diabetic rats.

  Life sciences 20060613

• Molluscicidal activity of Ferula asafoetida, Syzygium aromaticum and Carum carvi and their active components against the snail Lymnaea acuminata.

  Chemosphere 20060601

• Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.

  Drug metabolism and disposition: the biological fate of chemicals 20060401

• Relationships between chemical composition, physical properties and transfection efficiency of polysaccharide-spermine conjugates.

  Biomaterials 20060301

• Accumulation of coumarins in Arabidopsis thaliana.

  Phytochemistry 20060201

• Use of the land snail Helix aspersa as sentinel organism for monitoring ecotoxicologic effects of urban pollution: an integrated approach.

  Environmental health perspectives 20060101

• [A new dicoumarin from stem bark of Wikstroemia indica].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060101

• Inter-species comparison of 7-hydroxycoumarin glucuronidation and sulfation in liver S9 fractions.

  In vitro cellular & developmental biology. Animal 20060101

• Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation.

  Methods in molecular biology (Clifton, N.J.) 20060101

• Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families.

  Methods in molecular biology (Clifton, N.J.) 20060101

• Electrochemical profiles of Herba Saussureae Involucratae by capillary electrophoresis with electrochemical detection.

  Phytochemical analysis : PCA 20060101

• Gitksan medicinal plants--cultural choice and efficacy.

  Journal of ethnobiology and ethnomedicine 20060101

• Rapid analysis of coumarins using surface plasmon resonance.

  Journal of AOAC International 20060101

• Chemical constituents of Selinum cryptotaenium.

  Journal of Asian natural products research 20060101

• Ethnopharmacological evaluation of radal (leaves of Lomatia hirsuta) and isolation of 2-methoxyjuglone.

  BMC complementary and alternative medicine 20060101

• Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats.

  Journal of medicinal food 20060101

• Synthesis, characterization, and cytotoxic activity of new lanthanum(III) complexes of bis-coumarins.

  Bioinorganic chemistry and applications 20060101

• Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors.

  Bioinorganic chemistry and applications 20060101

• A direct fluorometric assay for tissue transglutaminase.

  Analytical biochemistry 20051215

• Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6.

  Biochemical and biophysical research communications 20051209

• Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.

  Drug metabolism and disposition: the biological fate of chemicals 20051101

• Synthesis and antiinflammatory activity of coumarin derivatives.

  Journal of medicinal chemistry 20051006

• New diorganotin(IV) derivatives of 7-hydroxycoumarin (umbelliferone) and their adducts with 1,10-phenanthroline.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001

• Activation of mitogen activated protein kinase pathways and melanogenesis by novel nitro-derivatives of 7-hydroxycomarin in human malignant melanoma cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901

• An odorant-binding protein facilitates odorant transfer from air to hydrophilic surroundings in the blowfly.

  Chemical senses 20050901

• Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin.

  Cancer chemotherapy and pharmacology 20050801

• Effects of coumarin and 7OH-coumarin on bcl-2 and Bax expression in two human lung cancer cell lines in vitro.

  Cell biology international 20050801

• Accumulation of biologically active furanocoumarins in agitated cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams.

  Die Pharmazie 20050801

• [Interaction between bovine serum albumin and umbelliferone with/without metal ions of Cu2+ or Zn2+].

  Guang pu xue yu guang pu fen xi = Guang pu 20050801

• Antihyperlipidemic and antidiabetic effects of umbelliferone in streptozotocin diabetic rats.

  The Yale journal of biology and medicine 20050701

• Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases.

  Analytical biochemistry 20050601

• Sulfation in dog.

  Current drug metabolism 20050601

• Post-stress metabolism involves umbelliferone production in anthocyanin-producing and nonproducing cells of Glehnia littoralis suspension cultures.

  Journal of plant physiology 20050601

• Plant-derived anti-inflammatory compounds affect MIF tautomerase activity.

  International immunopharmacology 20050501

• In vitro free radical and ONOO- scavengers from Sophora flavescens.

  Archives of pharmacal research 20050501

• Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water.

  Free radical research 20050501

• Impact of umbelliferone on erythrocyte redox status in STZ-diabetic rats.

  The Yale journal of biology and medicine 20050501

• Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6.

  The Journal of biological chemistry 20050401

• Design and development of a fluorescent probe for monitoring hydrogen peroxide using photoinduced electron transfer.

  Bioorganic & medicinal chemistry 20050215

• Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice.

  Cancer chemotherapy and pharmacology 20050201

• The influence of brain death on liver function.

  Liver international : official journal of the International Association for the Study of the Liver 20050201

• Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8.

  Drug metabolism and disposition: the biological fate of chemicals 20050101

• A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies.

  Journal of pharmacological and toxicological methods 20050101

• [Determination of scopoletin and umbelliferone contents in Saussurea medusa Maxim by high-performance liquid chromatography].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050101

• Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20050101

• Accumulation of biologically active furanocoumarins in Ruta graveolens ssp. divaricata (Tenore) Gams in vitro culture.

  Die Pharmazie 20050101

• Glucuronidation and sulfation of 7-hydroxycoumarin in liver matrices from human, dog, monkey, rat, and mouse.

  In vitro cellular & developmental biology. Animal 20050101

• Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese population.

  Drug metabolism and pharmacokinetics 20041201

• Determination of CC-5013, an analogue of thalidomide, in human plasma by liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041125

• Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers.

  Environmental health perspectives 20041101

• A study of the role of cell cycle events mediating the action of coumarin derivatives in human malignant melanoma cells.

  Cancer letters 20041008

• Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats.

  British journal of cancer 20041004

• Novel squalene-hopene cyclase inhibitors derived from hydroxycoumarins and hydroxyacetophenones.

  Chemical & pharmaceutical bulletin 20041001

• Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives.

  Bioscience, biotechnology, and biochemistry 20041001

• Umbelliferone released from hairy root cultures of Pharbitis nil treated with copper sulfate and its subsequent glucosylation.

  Bioscience, biotechnology, and biochemistry 20040901

• Metabolic and structural viability of precision-cut rat lung slices in culture.

  Xenobiotica; the fate of foreign compounds in biological systems 20040801

• Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.

  Archives of biochemistry and biophysics 20040715

• Effect of bisphenol A on drug metabolising enzymes in rat hepatic microsomes and precision-cut rat liver slices.

  Archives of toxicology 20040701

• Validated assays for human cytochrome P450 activities.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation.

  Organic & biomolecular chemistry 20040521

• Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase.

  Bioorganic & medicinal chemistry letters 20040503

• Functional co-expression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in yeast microsomes.

  Biochimica et biophysica acta 20040503

• An active and water-soluble truncation mutant of the human UDP-glucuronosyltransferase 1A9.

  Molecular pharmacology 20040401

• Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects.

  Toxicology letters 20040321

• Investigation of intracellular signalling events mediating the mechanism of action of 7-hydroxycoumarin and 6-nitro-7-hdroxycoumarin in human renal cells.

  Cancer letters 20040308

• Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru.

  Journal of natural products 20040301

• Apoptosis and cell cycle disturbances induced by coumarin and 7-hydroxycoumarin on human lung carcinoma cell lines.

  Lung cancer (Amsterdam, Netherlands) 20040301

• [Isolation and structure identification of the chemical constituents from pine needles of Pinus massoniana Lamb].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040301

• Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon.

  Xenobiotica; the fate of foreign compounds in biological systems 20040301

• Phase I and II enzyme characterization of two sources of HepG2 cell lines.

  Xenobiotica; the fate of foreign compounds in biological systems 20040301

• Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation.

  Toxicology in vitro : an international journal published in association with BIBRA 20040201

• Absolute stereochemistry of dihydrofuroangelicins bearing C-8 substituted double bonds: a combined chemical/exciton chirality protocol.

  Organic & biomolecular chemistry 20040107

• [Isolation and structural identification of chemical constituents from Selaginella tamariscina (Beauv.) Spring].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040101

• Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer.

  Current pharmaceutical design 20040101

• Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.

  Xenobiotica; the fate of foreign compounds in biological systems 20040101

• Quantitative changes of secondary metabolites of Matricaria chamomilla by abiotic stress.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

• Genetics of tobacco use.

  Tobacco induced diseases 20040101

• Study of inhibition of CYP2A6 by some drugs derived from quinoline.

  The Journal of pharmacy and pharmacology 20031201

• 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies.

  Xenobiotica; the fate of foreign compounds in biological systems 20031201

• Modulation of mitogen-activated protein kinases by 6-nitro-7-hydroxycoumarin mediates apoptosis in renal carcinoma cells.

  European journal of pharmacology 20031128

• The first fluorogenic assay for detecting a Baeyer-Villigerase activity in microbial cells.

  Organic & biomolecular chemistry 20031021

• Coumarins from Peucedanum wulongense.

  Journal of Asian natural products research 20030901

• Application of capillary electrophoresis with pH-mediated sample stacking to analysis of coumarin metabolites in microsomal incubations.

  Journal of pharmaceutical and biomedical analysis 20030808

• A low background high-throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone.

  Bioorganic & medicinal chemistry letters 20030707

• Interactions of a series of novel spiropyranocoumarin derivatives with reactive oxygen species.

  The Journal of pharmacy and pharmacology 20030701

• Spectrofluorimetric analysis of 7-hydroxycoumarin binding to bovine phenol sulfotransferase.

  Biochimica et biophysica acta 20030530

• Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives.

  Journal of natural products 20030501

• Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin.

  International journal of clinical pharmacology and therapeutics 20030401

• Fluorogenic stereochemical probes for transaldolases.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20030217

• Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid.

  Journal of agricultural and food chemistry 20030212

• Comparative metabolism and kinetics of coumarin in mice and rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030201

• Protection of coumarins against linoleic acid hydroperoxide-induced cytotoxicity.

  Chemico-biological interactions 20030106

• Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH?

  American journal of physiology. Heart and circulatory physiology 20030101

• CYP2A13-catalysed coumarin metabolism: comparison with CYP2A5 and CYP2A6.

  Xenobiotica; the fate of foreign compounds in biological systems 20030101

• Chemical constituents from the Hydrangea chinensis.

  Archives of pharmacal research 20030101

• Potential functional foods in the traditional Maori diet.

  Mutation research 20030101

• Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel.

  In vitro cellular & developmental biology. Animal 20030101

• Structural requirements of hydroxylated coumarins for in vitro anti-Helicobacter pylori activity.

  In vivo (Athens, Greece) 20030101

• Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

• Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.

  Journal of natural products 20021101

• Characterization of testosterone metabolism and 7-hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months.

  Xenobiotica; the fate of foreign compounds in biological systems 20021101

• [Prediction of eluotropic sequence of solutes in countercurrent chromatography].

  Se pu = Chinese journal of chromatography 20021101

• Inhibition of bovine phenol sulfotransferase (bSULT1A1) by CoA thioesters. Evidence for positive cooperativity and inhibition by interaction with both the nucleotide and phenol binding sites.

  The Journal of biological chemistry 20021018

• A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma.

  Biomedical chromatography : BMC 20020901

• Phenotypic polymorphism of CYP2A6 activity in a Chinese population.

  European journal of clinical pharmacology 20020801

• [Studies on the chemical constituents from the roots and rhizomes of Gerbera piloselloides].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020801

• Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices.

  Xenobiotica; the fate of foreign compounds in biological systems 20020501

• Superoxide organic chemistry within the liposomal bilayer, part II: a correlation between location and chemistry.

  Free radical biology & medicine 20020401

• Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females.

  Pharmacogenetics 20020401

• Some coumarins and triphenylethene derivatives as inhibitors of human testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD type 3): further studies with tamoxifen on the rat testes microsomal enzyme.

  Journal of enzyme inhibition and medicinal chemistry 20020401

• A novel ISFET-type biosensor based on P450 monooxygenases.

  Biosensors & bioelectronics 20020301

• Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarin in human liver microsomes treated with alamethicin.

  Drug metabolism and disposition: the biological fate of chemicals 20020301

• A rapid fluorescence-based assay for detecting soluble methane monooxygenase.

  Applied microbiology and biotechnology 20020201

• Inhibitory effects of phenylpropanoid metabolites on copper-induced protein oxidative modification of mice brain homogenate, in vitro.

  Biological trace element research 20020201

• An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles.

  Biochemical and biophysical research communications 20020111

• Induction of 4-hydroxycinnamate decarboxylase in Klebsiella oxytoca cells exposed to substrates and non-substrate 4-hydroxycinnamate analogs.

  Bioscience, biotechnology, and biochemistry 20011201

• [Constituents of Liguliria vellerea (Franch.) Hand-Mazz].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011201

• Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin.

  Journal of molecular biology 20011130

• Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products.

  Archives of biochemistry and biophysics 20011101

• Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin.

  Lung cancer (Amsterdam, Netherlands) 20011101

• [Nonpolar components of the leaves of Philadelphus coronarius L].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20011101

• Characterization of peroxidase-mediated chlorophyll bleaching in strawberry fruit.

  Phytochemistry 20011001

• Tissue slices revisited: evaluation and development of a short-term incubation for integrated drug metabolism.

  Drug metabolism and disposition: the biological fate of chemicals 20011001

• The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins.

  Archives of biochemistry and biophysics 20011001

• Study of the in vitro cytotoxic potential of natural and synthetic coumarin derivatives using human normal and neoplastic skin cell lines.

  Melanoma research 20011001

• A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.

  Bioorganic & medicinal chemistry letters 20010903

• [Studies on chemical constituents of Stellera chamejasma L].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010701

• Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion.

  Drug metabolism and disposition: the biological fate of chemicals 20010601

• Consumption of watercress fails to alter coumarin metabolism in humans.

  Drug metabolism and disposition: the biological fate of chemicals 20010601

• Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.

  Journal of natural products 20010501

• Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur.

  Japanese journal of cancer research : Gann 20010501

• Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion.

  Drug metabolism and disposition: the biological fate of chemicals 20010401

• Determination of coumarin metabolism in Turkish population.

  Human & experimental toxicology 20010401

• Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms.

  Drug metabolism and disposition: the biological fate of chemicals 20010301

• The in vivo dermal absorption and metabolism of [4-14C] coumarin by rats and by human volunteers under simulated conditions of use in fragrances.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010201

• [Sensitization and crossreaction of simple coumarins].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101

• Excited-state dipole moments of some hydroxycoumarin dyes using an efficient solvatochromic method based on the solvent polarity parameter, EN(T).

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010101

• High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1.

  Rapid communications in mass spectrometry : RCM 20010101

• Medicinal and ethnoveterinary remedies of hunters in Trinidad.

  BMC complementary and alternative medicine 20010101

• A new bicoumarin from Stellera chamaejasme L.

  Journal of Asian natural products research 20010101

• Steroid hormone activity of flavonoids and related compounds.

  Breast cancer research and treatment 20000701

• St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

  Proceedings of the National Academy of Sciences of the United States of America 20000620

• Metabolism of N-nitrosobenzylmethylamine by human cytochrome P-450 enzymes.

  Journal of toxicology and environmental health. Part A 19991210

• Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.

  Journal of medicinal chemistry 19990826

• Mono- and sesquiterpenes and antifungal constituents from Artemisia species.

  Planta medica 19990201

• Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications.

  Pharmacogenetics 19971201

• Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.

  Archives of biochemistry and biophysics 19951001

• Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.

  Drug metabolism and disposition: the biological fate of chemicals 19940101

• Inhibitory effect of coumarins on HIV-1 replication and cell-mediated or cell-free viral transmission.

  Acta virologica 19930801