93-60-7 | Methyl nicotinate

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$15.00	$10.00
5g	98%	in stock	$16.00	$11.00
25g	98%	in stock	$18.00	$12.00
100g	98%	in stock	$35.00	$24.00
500g	98%	in stock	$99.00	$69.00

Description

• Catalog Number: AB76105
• Chemical Name: Methyl nicotinate
• CAS Number: 93-60-7
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.13598
• MDL Number: MFCD00006388
• SMILES: COC(=O)c1cccnc1

Computed Properties

• Complexity: 125
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• XLogP3: 0.8

Literature

• Status of surfactants as penetration enhancers in transdermal drug delivery.

  Journal of pharmacy & bioallied sciences 20120101

• Honeybees Apis mellifera can detect the scent of Mycobacterium tuberculosis.

  Tuberculosis (Edinburgh, Scotland) 20110701

• Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion.

  Physical chemistry chemical physics : PCCP 20110328

• Human skin penetration of a copper tripeptide in vitro as a function of skin layer.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110101

• Persistent erythema with niacin is not attributable to aspirin resistance.

  Journal of clinical lipidology 20110101

• Evodia rutaecarpa and Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Chemokines Production and Cell Migration.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Suppression of jasmonic acid-dependent defense in cotton plant by the mealybug Phenacoccus solenopsis.

  PloS one 20110101

• Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.

  Journal of liposome research 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Niacin sensitivity and the arachidonic acid pathway in schizophrenia.

  Schizophrenia research 20100901

• In vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum.

  The AAPS journal 20091201

• Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091105

• Excess substrate is a spectator ligand in a rhodium-catalyzed asymmetric [2 + 2 + 2] cycloaddition of alkenyl isocyanates with tolanes.

  Organic letters 20091105

• The scent of Mycobacterium tuberculosis--part II breath.

  Tuberculosis (Edinburgh, Scotland) 20090701

• Effects of lipid nanocarriers on the performance of topical vehicles in vivo.

  Journal of cosmetic dermatology 20090601

• Impaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: the effect of genetic loading.

  Schizophrenia bulletin 20090101

• Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration.

  Journal of biomedical optics 20090101

• Contact urticaria: present scenario.

  Indian journal of dermatology 20090101

• The scent of Mycobacterium tuberculosis.

  Tuberculosis (Edinburgh, Scotland) 20080701

• In vivo methods for the assessment of topical drug bioavailability.

  Pharmaceutical research 20080101

• Evaluation of simultaneous permeation and metabolism of methyl nicotinate in human, snake, and shed snake skin.

  Pharmaceutical development and technology 20080101

• In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols.

  Journal of cosmetic science 20080101

• The topical niacin sensitivity test: an inter- and intra-rater reliability study in healthy controls.

  Prostaglandins, leukotrienes, and essential fatty acids 20080101

• Stability of methylnicotinate in aqueous solution as utilized in the 'niacin patch test'.

  BMC research notes 20080101

• The role of vitamins and minerals in psychiatry.

  Integrative medicine insights 20080101

• A new coordination mode of 6-methylnicotinic acid in trans-tetraaquabis(6-methylpyridine-3-carboxylato-kappaO)cobalt(II) tetrahydrate.

  Acta crystallographica. Section C, Crystal structure communications 20071201

• Sub-epidermal imaging using polarized light spectroscopy for assessment of skin microcirculation.

  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20071101

• Cannabinoids influence lipid-arachidonic acid pathways in schizophrenia.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20071001

• Influence of skin colour on the detection of cutaneous erythema and tanning phenomena using reflectance spectrophotometry.

  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20070801

• Niacin skin test response in dyslexia.

  Prostaglandins, leukotrienes, and essential fatty acids 20070801

• Percutaneous penetration of methyl nicotinate from ointments using the laser Doppler technique: bioequivalence and enhancer effects.

  Journal of pharmacokinetics and pharmacodynamics 20061201

• Transfer of the experimental methodology described in the FDA guidance for corticosteroid bioequivalence testing to pharmacodynamic effects caused by nicotinates.

  Journal of cosmetic dermatology 20061201

• A non-invasive method for the in vivo determination of skin antioxidant capacity (IAC-S).

  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20061101

• Niacin skin flushing in schizophrenic and depressed patients and healthy controls.

  Psychiatry research 20060830

• Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay.

  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20060801

• Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.

  Journal of medicinal chemistry 20060629

• Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine.

  Journal of dermatological science 20060401

• In-vitro and in-vivo evaluation of oligoethylene esters as dermal prodrugs of 18beta-glycyrrhetic acid.

  The Journal of pharmacy and pharmacology 20060301

• Establishing a minimal erythema concentration of methyl nicotinate for optimum evaluation of anti-inflammatories.

  Skin pharmacology and physiology 20060101

• Cluster analysis of the dermal permeability and stratum corneum/solvent partitioning of ten chemicals in twenty-four chemical mixtures in porcine skin.

  Skin pharmacology and physiology 20060101

• Time of erythema onset after application of methyl nicotinate ointments as response parameter: influence of penetration kinetics and enhancing agents.

  Skin pharmacology and physiology 20060101

• Isolation and characterization of 3-carbomethoxypyridine from the leaves of Pyrenacantha staudtii Hutch and Dalz (Icacinaceae).

  Acta poloniae pharmaceutica 20060101

• Pattern recognition analysis for classification of hypertensive model rats and diurnal variation using 1H-NMR spectroscopy of urine.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20051101

• Predicting skin permeability from complex chemical mixtures.

  Toxicology and applied pharmacology 20051015

• Effect of charge and lipid concentration on in-vivo percutaneous absorption of methyl nicotinate from liposomal vesicles.

  The Journal of pharmacy and pharmacology 20050901

• Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers.

  Journal of controlled release : official journal of the Controlled Release Society 20050818

• Impaired niacin sensitivity in acute first-episode but not in multi-episode schizophrenia.

  Prostaglandins, leukotrienes, and essential fatty acids 20050601

• Clinical microneedle injection of methyl nicotinate: stratum corneum penetration.

  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20050501

• Objective biophysical findings in patients with sensitive skin.

  Drugs under experimental and clinical research 20050101

• Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder.

  Journal of affective disorders 20041015

• Intramolecular Photocycloaddition of Unsaturated Isoquinuclidines. Synthesis of 2-Azatetracyclo[4.0.0.(4,9)0(7,10)]decanes and 3-Azatetracyclo[6.1.1.0.(2,7)0(5,9)]decanes.

  The Journal of organic chemistry 20040528

• Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema.

  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20040515

• Reduced vasodilatory response to methylnicotinate in schizophrenia as assessed by laser Doppler flowmetry.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040501

• Preparation of deuterated methyl and dimethyl substituted nicotinoylating agents for derivatization of the N-terminal of protein.

  Chemical & pharmaceutical bulletin 20031201

• Methyl nicotinate-induced vasodilation in generalized social phobia.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031001

• Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with topical pharmacological effect.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20031001

• On the relationship between methylnicotinate-induced skin flush and fatty acids levels in acute psychosis.

  Progress in neuro-psychopharmacology & biological psychiatry 20030901

• The niacin skin flush abnormality in schizophrenia: a quantitative dose-response study.

  Schizophrenia research 20030801

• Determination of antioxidant efficacy of cosmetic formulations by non-invasive measurements.

  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20030801

• Formulation study and anti-inflammatory efficacy of topical semi-solids containing a nitro ester of flurbiprofen.

  Skin pharmacology and applied skin physiology 20030101

• Topical methyl nicotinate-induced skin vasodilation in diabetic neuropathy.

  Journal of diabetes and its complications 20030101

• Normal phospholipid-related signal transduction in autism.

  Progress in neuro-psychopharmacology & biological psychiatry 20021201

• Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transport.

  Toxicological sciences : an official journal of the Society of Toxicology 20021001

• Influence of processing conditions in the manufacture of O/W creams: II. Effect on drug availability.

  Farmaco (Societa chimica italiana : 1989) 20020501

• A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia.

  Progress in neuro-psychopharmacology & biological psychiatry 20020101

• Comparison of the effects of daily applications between topical corticosteroid and tacrolimus ointments on normal skin: evaluation with noninvasive methods.

  Dermatology (Basel, Switzerland) 20020101

• In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010901

• Impaired phospholipid-related signal transduction in advanced Huntington's disease.

  Experimental physiology 20010901

• Mixture component effects on the in vitro dermal absorption of pentachlorophenol.

  Archives of toxicology 20010801

• Selective fowler reductions: asymmetric total syntheses of isofagomine and other 1-azasugars from methyl nicotinate.

  Organic letters 20010125

• The niacin skin flush test in schizophrenia: a replication study.

  International journal of clinical practice 20010101

• Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship?

  Contact dermatitis 19980201