930-35-8 | 1,3-Dithiole-2-thione

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$129.00	$90.00
5g	97%	in stock	$510.00	$357.00

Description

• Catalog Number: AB54035
• Chemical Name: 1,3-Dithiole-2-thione
• CAS Number: 930-35-8
• Molecular Formula: C3H2S3
• Molecular Weight: 134.243
• MDL Number: MFCD00014536
• SMILES: S=c1sccs1

Computed Properties

• Complexity: 84.2
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 3
• XLogP3: 2

Literature

• Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1).

  Toxicology 20120928

• Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.

  Cancer research 20120501

• 6,6-Dimethyl-2H,5H,6H,7H-1,3-dithiolo[4,5-f][1,5,3]dithia-silepin-2-one.

  Acta crystallographica. Section E, Structure reports online 20120401

• 2-Methyl-sulfanyl-5,6-dihydro-2H-1,3-dithiolo[4,5-b][1,4]dioxin-2-ium tetra-fluoro-borate.

  Acta crystallographica. Section E, Structure reports online 20120401

• Mechanism of chemical activation of Nrf2.

  PloS one 20120101

• The yin and yang of nrf2-regulated selenoproteins in carcinogenesis.

  International journal of cell biology 20120101

• The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells.

  Experimental diabetes research 20120101

• 2-Sulfanylidene-1,3-dithiolo[4,5-b]naphtho-[2,3-e][1,4]dithiine-5,10-dione.

  Acta crystallographica. Section E, Structure reports online 20111101

• 5,6-Dihydro-2H-1,3-dithiolo[4,5-b][1,4]dioxine-2-thione.

  Acta crystallographica. Section E, Structure reports online 20110601

• S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling.

  PloS one 20110101

• 5,6-Diamino-1,3-benzodithiole-2-thione.

  Acta crystallographica. Section E, Structure reports online 20101201

• New aryldithiolethione derivatives as potent histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry 20100615

• 4,6,7,9,10,12,13,15,16,18-Decahydro-1,3-dithiolo[4,5-l][1,4,7,10,15]trioxadithia-cyclo-hepta-decine-2-thione.

  Acta crystallographica. Section E, Structure reports online 20100601

• Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

  Lung cancer (Amsterdam, Netherlands) 20100501

• Modulation of thiol homeostasis induced by H2S-releasing aspirin.

  Free radical biology & medicine 20100501

• HPLC determination of novel dithiolethione containing drugs and its application for in vivo studies in rats.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

• PSMB7 is associated with anthracycline resistance and is a prognostic biomarker in breast cancer.

  British journal of cancer 20100119

• Redox-active tetrathiafulvalene and dithiolene compounds derived from allylic 1,4-diol rearrangement products of disubstituted 1,3-dithiole derivatives.

  Beilstein journal of organic chemistry 20100101

• Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.

  Oncogene 20091029

• Therapeutic potential of dithiolethiones for hepatic diseases.

  Pharmacology & therapeutics 20091001

• Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect.

  Molecular cancer therapeutics 20091001

• Structural and vibrational studies of molecular conductors using quantum mechanical methods: 1,3-Dithiole-2-thione, 1,3-dithiole-2-one, 1,3-dioxole-2-one and 1,3-dioxole-2-thione.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090915

• Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.

  Chemical research in toxicology 20090817

• 4,6,7,9,10,12-Hexahydro-1,3-dithiolo[4,5-f][1,4,9]oxadithia-cyclo-undecine-2-thione.

  Acta crystallographica. Section E, Structure reports online 20090701

• Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090315

• Chemical genomics of cancer chemopreventive dithiolethiones.

  Carcinogenesis 20090301

• 3-(2-Thioxo-1,3-dithiol-4-ylsulfan-yl)-propane-nitrile.

  Acta crystallographica. Section E, Structure reports online 20081101

• New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.

  Bioorganic & medicinal chemistry letters 20080315

• An Hg2+-gated chiral molecular switch created by using binaphthalene molecules with two anthracene units and two 1,3-dithiole-2-thione (1,3-dithiole-2-one) units.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.

  European journal of pharmacology 20071222

• Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway.

  Hepatology (Baltimore, Md.) 20070901

• Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein.

  Life sciences 20070606

• Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.

  PLoS medicine 20070601

• Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

  British journal of pharmacology 20070501

• The thiol antioxidant 1,2-dithiole-3-thione stimulates the expression of heat shock protein 70 in dopaminergic PC12 cells.

  Neuroscience letters 20070406

• Thiolated pi-extended tetrathiafulvalenes: versatile multifunctional pi-systems.

  The Journal of organic chemistry 20070216

• The nature of the chemical bond in linear three-body systems: from i3- to mixed chalcogen/halogen and trichalcogen moieties.

  Bioinorganic chemistry and applications 20070101

• The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model.

  Carcinogenesis 20060801

• The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes.

  Journal of neural transmission (Vienna, Austria : 1996) 20060501

• Reactions Between Chalcogen Donors and Dihalogens/Interalogens: Typology of Products and Their Characterization by FT-Raman Spectroscopy.

  Bioinorganic chemistry and applications 20060101

• 1,3-Dithiole-2-thione derivatives featuring an anthracene unit: new selective chemodosimeters for Hg(II) ion.

  Chemical communications (Cambridge, England) 20050428

• Safety and efficacy of weekly oral oltipraz in chronic smokers.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050401

• NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.

  The Journal of biological chemistry 20040618

• Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz.

  Carcinogenesis 20031201

• Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.

  Journal of the National Cancer Institute 20030101

• Chemoprotective potential of phase 2 enzyme inducers.

  Expert review of anticancer therapy 20021001