93249-62-8 | 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$19.00	$13.00
5g	95%	in stock	$62.00	$43.00
10g	95%	in stock	$109.00	$76.00
25g	95%	in stock	$169.00	$118.00
100g	95%	in stock	$566.00	$396.00

Description

• Catalog Number: AB62328
• Chemical Name: 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde
• CAS Number: 93249-62-8
• Molecular Formula: C8H5F3O3
• Molecular Weight: 206.1187096
• MDL Number: MFCD00075249
• SMILES: O=Cc1cc(ccc1O)OC(F)(F)F

Computed Properties

• Complexity: 205
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.8

Upstream Synthesis Route

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde is a versatile compound often used in chemical synthesis due to its unique properties. This compound is commonly employed as a building block in the creation of various complex organic molecules. Its trifluoromethoxy group, which is electron-withdrawing, can influence the reactivity and selectivity of reactions in which it is involved.One key application of 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde is in the synthesis of pharmaceuticals. The presence of the hydroxy and trifluoromethoxy groups in this compound can be strategically utilized to introduce specific functionality into drug molecules, potentially impacting their bioavailability, potency, or metabolic stability.Furthermore, the reactivity of 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde towards various nucleophiles allows for the formation of new carbon-carbon or carbon-heteroatom bonds, facilitating the construction of more complex molecular structures. Its use in coupling reactions, cyclization processes, and as a starting material for the synthesis of heterocyclic compounds highlights its importance in medicinal and materials chemistry.

Literature

• 2-[(E)-(Naphthalen-2-yl-imino)-meth-yl]-4-(trifluoro-meth-oxy)phenol.

  Acta crystallographica. Section E, Structure reports online 20120401

• 2-[(E)-2-Hy-droxy-5-(trifluoro-meth-oxy)benzyl-idene-amino]-4-methyl-phenol.

  Acta crystallographica. Section E, Structure reports online 20110101

• (E)-2-[(3-Fluoro-phen-yl)imino-meth-yl]-4-(trifluoro-meth-oxy)phenol.

  Acta crystallographica. Section E, Structure reports online 20100301

• (E)-2-[(4-Chloro-phen-yl)imino-meth-yl]-4-(trifluoro-meth-oxy)phenol.

  Acta crystallographica. Section E, Structure reports online 20091101