934-32-7 | 2-Aminobenzimidazole

Packsize	Purity	Availability	Price	Discounted Price
10g	98%	in stock	$8.00	$5.00
25g	98%	in stock	$10.00	$7.00
100g	98%	in stock	$35.00	$24.00

Description

• Catalog Number: AC84099
• Chemical Name: 2-Aminobenzimidazole
• CAS Number: 934-32-7
• Molecular Formula: C7H7N3
• Molecular Weight: 133.15058000000002
• MDL Number: MFCD00005596
• SMILES: Nc1nc2c([nH]1)cccc2

Computed Properties

• Complexity: 126
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• XLogP3: 0.9

Literature

• Microheterogeneity in native and cation-exchanged Nafion membranes.

  The journal of physical chemistry. B 20120823

• Bis(2-amino-1H-benzimidazol-3-ium) tetrakis(μ-but-2-enoato)-κ4O:O';κ3O,O':O;κ3O:O,O'-bis[bis(but-2-enoato-κ2O,O')holmium(III)].

  Acta crystallographica. Section C, Crystal structure communications 20120701

• Hollow-fiber liquid-phase microextraction for the determination of pesticides and metabolites in soils and water samples using HPLC and fluorescence detection.

  Electrophoresis 20120701

• 2-Aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms.

  Angewandte Chemie (International ed. in English) 20120521

• Mixed ligand copper(II) complexes of N,N-bis(benzimidazol-2-ylmethyl)amine (BBA) with diimine co-ligands: efficient chemical nuclease and protease activities and cytotoxicity.

  Inorganic chemistry 20120521

• Dispersive liquid-liquid microextraction of pesticides and metabolites from soils using 1,3-dipentylimidazolium hexafluorophosphate ionic liquid as an alternative extraction solvent.

  Electrophoresis 20120501

• Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

  The Journal of antimicrobial chemotherapy 20120201

• Molecular structure, vibrational spectroscopic, first-order hyperpolarizability and HOMO, LUMO studies of 2-aminobenzimidazole.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111215

• Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.

  Bioorganic & medicinal chemistry letters 20111201

• 1-Prop-2-ynyl-1H-benzimidazol-2-amine.

  Acta crystallographica. Section E, Structure reports online 20111201

• Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents.

  Archives of pharmacal research 20111001

• Removal of nonspecific binding proteins from cell and tissue extracts using 2-aminobenzimidazole-tethered affinity resin.

  Die Pharmazie 20110901

• Detection of benzimidazole carbamates and amino metabolites in liver by surface plasmon resonance-biosensor.

  Analytica chimica acta 20110826

• Accurate predictions of nonpolar solvation free energies require explicit consideration of binding-site hydration.

  Journal of the American Chemical Society 20110824

• 2-Amino-6-nitro-1,3-benzothia-zol-3-ium hydrogen sulfate.

  Acta crystallographica. Section E, Structure reports online 20110801

• 3,3'-Dichloro-biphenyl-4,4'-diaminium sulfate.

  Acta crystallographica. Section E, Structure reports online 20110801

• Ionic liquid-dispersive liquid-liquid microextraction for the simultaneous determination of pesticides and metabolites in soils using high-performance liquid chromatography and fluorescence detection.

  Journal of chromatography. A 20110729

• Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.

  Chemistry & biology 20110729

• Aggregation of 2-aminobenzimidazole--a combined experimental and theoretical investigation.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20110620

• Chromogenic and fluorescent recognition of iodide with a benzimidazole-based tripodal receptor.

  Organic letters 20110617

• Biodegradation kinetics of the benzimidazole fungicide thiophanate-methyl by bacteria isolated from loamy sand soil.

  Biodegradation 20110601

• A protocol to 2-aminobenzimidazoles via copper-catalyzed cascade addition and cyclization of o-haloanilines and carbodiimides.

  The Journal of organic chemistry 20110506

• Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

  ChemMedChem 20110207

• One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones.

  European journal of medicinal chemistry 20110101

• Synthesis of benzothiophene carboxamide derivatives and their pharmacological evaluation as potent antihypertriglyceridemic agents in rats.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101

• A facile and convenient synthesis of some novel hydrazones, Schiff's base and pyrazoles incorporating thieno[2,3-b]thiophenes.

  International journal of molecular sciences 20110101

• Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.

  Frontiers in pharmacology 20110101

• Isolation and characterization of Pseudomonas sp. CBW capable of degrading carbendazim.

  Biodegradation 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Biodegradation of carbendazim by a novel actinobacterium Rhodococcus jialingiae djl-6-2.

  Chemosphere 20101001

• Experimental and theoretical studies on the mechanism of photochemical hydrogen transfer from 2-aminobenzimidazole to nπ* and ππ* aromatic ketones.

  The journal of physical chemistry. B 20100916

• Fragment-based discovery and optimization of BACE1 inhibitors.

  Bioorganic & medicinal chemistry letters 20100901

• Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules.

  Journal of medicinal chemistry 20100624

• Experimental and theoretical (DFT) characterization of the excited states and N-centered radical species derived from 2-aminobenzimidazole, the core substructure of a family of bioactive compounds.

  The journal of physical chemistry. B 20100520

• The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia.

  Bioorganic & medicinal chemistry letters 20100501

• 3,4-Dimethyl-1H-1,2,4-triazepino[2,3-a]benzimidazol-2(3H)-one.

  Acta crystallographica. Section E, Structure reports online 20100501

• Zinc fingered: new compounds that thwart gram-positive biofilm formation by sequestering zinc.

  Chembiochem : a European journal of chemical biology 20100412

• Design, synthesis, and in vitro antiproliferative activity of benzimidazole analogues for radiopharmaceutical efficacy.

  Cancer biotherapy & radiopharmaceuticals 20100401

• Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C.

  ACS chemical biology 20100319

• Concise synthesis of 2, 3-diarylpyrimido[1,2-a]benzimidazole based on isoflavones.

  Journal of combinatorial chemistry 20100308

• Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles.

  Bioorganic & medicinal chemistry letters 20100201

• The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.

  Bioorganic & medicinal chemistry 20100115

• The leucine zipper domains of the transcription factors GCN4 and c-Jun have ribonuclease activity.

  PloS one 20100101

• 2-Aminobenzimidazoles as potent Aurora kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20090901

• Simultaneous analysis of thiabendazole, carbendazim and 2-aminobenzimidazole in concentrated fruit juices by liquid chromatography after a single mix-mode solid-phase extraction cleanup.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20090801

• 2-Amino-6-nitro-1H-benzoimidazol-3-ium chloride.

  Acta crystallographica. Section E, Structure reports online 20090801

• Ethyl 5-[(1H-benzoimidazol-2-yl)amino-carbon-yl]-4-hydr-oxy-2-methyl-6-oxo-1-propyl-1,6-dihydro-pyridine-3-carboxyl-ate-ethanol-methanol (4/2/1).

  Acta crystallographica. Section E, Structure reports online 20090801

• A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

  Journal of the American Chemical Society 20090729

• One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

  Journal of medicinal chemistry 20090723

• Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

  Bioorganic & medicinal chemistry letters 20090701

• [Characterization of a carbendazim-degrading Trichoderma sp. T2-2 and its application in bioremediation].

  Wei sheng wu xue bao = Acta microbiologica Sinica 20090701

• IRAK-4 inhibitors for inflammation.

  Current topics in medicinal chemistry 20090501

• QSAR analysis of 2-amino or 2-methyl-1-substituted benzimidazoles against Pseudomonas aeruginosa.

  International journal of molecular sciences 20090401

• New sensitive kinetic spectrophotometric methods for determination of omeprazole in dosage forms.

  International journal of analytical chemistry 20090101

• 2-Amino-benzimidazolium hydrogen sulfate.

  Acta crystallographica. Section E, Structure reports online 20090101

• 2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket.

  Bioorganic & medicinal chemistry letters 20081201

• 2-Amino-1H-benzoimidazol-3-ium 4,4,4-trifluoro-1,3-dioxo-1-phenyl-butan-2-ide.

  Acta crystallographica. Section E, Structure reports online 20081201

• Discovery of potent, orally active benzimidazole glucagon receptor antagonists.

  Bioorganic & medicinal chemistry letters 20080701

• Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3.

  Bioorganic & medicinal chemistry letters 20080401

• Reaction of nitrilimines with 2-substituted aza-heterocycles. Synthesis of pyrrolo[1,2-a]pyridine and pyrimido[2,1-d]1,2,3,5- tetrazine.

  Molecules (Basel, Switzerland) 20080128

• Synthesis, structure and biological activities of cobalt(II) and zinc(II) coordination compounds with 2-benzimidazole derivatives.

  Journal of inorganic biochemistry 20080101

• A three component one-pot procedure for the synthesis of [1,2,4]triazolo/benzimidazolo-quinazolinone derivatives in the presence of H6P2W18O(62).18H2O as a green and reusable catalyst.

  Molecular diversity 20080101

• Synthesis and antitrichinellosis activity of some bis(benzimidazol-2-yl)amines.

  Bioorganic & medicinal chemistry 20070915

• Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.

  Bioorganic & medicinal chemistry 20070601

• Benzimidazole condensed ring systems: new synthesis and antineoplastic activity of substituted 3,4-dihydro- and 1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyrimidine derivatives.

  Archives of pharmacal research 20070601

• Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201

• Molecular modeling of some 1H-benzimidazole derivatives with biological activity against Entamoeba histolytica: a comparative molecular field analysis study.

  Bioorganic & medicinal chemistry 20070115

• Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles.

  The Journal of organic chemistry 20070105

• Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones.

  Beilstein journal of organic chemistry 20070101

• Synthesis of tetrahydrobenzimidazo[1,2-b]quinazolin-1(2H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one ring systems under solvent-free conditions.

  Combinatorial chemistry & high throughput screening 20061201

• An in vitro investigation on acid catalyzed reactions of proton pump inhibitors in the absence of an electrophile.

  International journal of pharmaceutics 20061012

• Toward bifunctional antibody catalysis.

  Bioorganic & medicinal chemistry 20060915

• Synthesis and QSAR studies of novel 1-substituted-2-aminobenzimidazoles derivatives.

  European journal of medicinal chemistry 20060901

• Isolation and characterization of a carbendazim-degrading Rhodococcus sp. djl-6.

  Current microbiology 20060701

• Site-specific cleavage of RNA by a metal-free artificial nuclease attached to antisense oligonucleotides.

  Journal of the American Chemical Society 20060621

• Structure-guided design of peptide-based tryptase inhibitors.

  Biochemistry 20060516

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series.

  Bioorganic & medicinal chemistry 20060301

• A novel one-pot three-component reaction: synthesis of triheterocyclic 4H-pyrimido[2,1-b]benzazoles ring systems.

  Bioorganic & medicinal chemistry letters 20051215

• In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors.

  Bioorganic & medicinal chemistry letters 20051201

• Validation of a histamine H3 receptor model through structure-activity relationships for classical H3 antagonists.

  Bioorganic & medicinal chemistry 20051001

• Convenient synthesis of fused heterocyclic 1,3,5-triazines from some N-acyl imidates and heterocyclic amines as anticancer and antioxidant agents.

  Archiv der Pharmazie 20050801

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Determination of azolic fungicides in wine by solid-phase extraction and high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.

  Journal of chromatography. A 20050527

• Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20050415

• Influence of solvent properties on separation and detection performance in non-aqueous capillary electrophoresis-mass spectrometry of basic analytes.

  Journal of chromatography. A 20050311

• Metal-free catalysts for the hydrolysis of RNA derived from guanidines, 2-aminopyridines, and 2-aminobenzimidazoles.

  Journal of the American Chemical Society 20050223

• Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

  Journal of molecular biology 20041119

• Simultaneous separation and on-line concentration of amitrole and benzimidazole pesticides by capillary electrophoresis with a volatile migration buffer applicable to mass spectrometric detection.

  Journal of chromatography. A 20041008

• Inhibition of human immunodeficiency virus type I integrase by naphthamidines and 2-aminobenzimidazoles.

  Antiviral research 20041001

• Heterocyclic bis-cations as starting hits for design of inhibitors of the bifunctional enzyme histidine-containing protein kinase/phosphatase from Bacillus subtilis.

  Journal of medicinal chemistry 20040422

• Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists.

  Bioorganic & medicinal chemistry 20040215

• Synthesis and antiproliferative activity in vitro of 2-aminobenzimidazole derivatives.

  Farmaco (Societa chimica italiana : 1989) 20040201

• Generation of bis-cationic heterocyclic inhibitors of Bacillus subtilis HPr kinase/phosphatase from a ditopic dynamic combinatorial library.

  Journal of medicinal chemistry 20031218

• The role of HB-donor groups in the heterocyclic polar fragment of H3-antagonists. I. Synthesis and biological assays.

  Farmaco (Societa chimica italiana : 1989) 20030901

• Identification of 2-aminobenzimidazole dimers as antibacterial agents.

  Bioorganic & medicinal chemistry letters 20030519

• Photochemical behaviour of carbendazim in aqueous solution.

  Chemosphere 20030201

• Copper- and palladium-catalyzed intramolecular aryl guanidinylation: an efficient method for the synthesis of 2-aminobenzimidazoles.

  Organic letters 20030123

• Carbendazim: disposition, cellular permeability, metabolite identification, and pharmacokinetic comparison with its nanoparticle.

  Journal of pharmaceutical sciences 20030101

• On-line automated sample preparation for liquid chromatography using parallel supported liquid membrane extraction and microporous membrane liquid-liquid extraction.

  Journal of chromatography. A 20021025

• Synthesis and antiparasitic activity of 1H-benzimidazole derivatives.

  Bioorganic & medicinal chemistry letters 20020819

• Kinetic study of catalytic CO(2) hydration by water-soluble model compound of carbonic anhydrase and anion inhibition effect on CO(2) hydration.

  Journal of inorganic biochemistry 20020428

• Preparation, physicochemical characterization and pharmacological study of novel ruthenium(III) complexes with imidazole and benzimidazole derivatives.

  Arzneimittel-Forschung 20010901

• Trigonal planar copper(I) complex: synthesis, structure, and spectra of a redox pair of novel copper(II/I) complexes of tridentate bis(benzimidazol-2'-yl) ligand framework as models for electron-transfer copper proteins.

  Inorganic chemistry 20010507

• Potential transition state phosphoramidate inhibitors of beta-tubulin as antifilarial agents.

  The Journal of pharmacy and pharmacology 20010101

• Thermodynamic and multinuclear magnetic resonance study of dimethyltin (IV) complexes with some imidazoles in aqueous solutions.

  Annali di chimica 20010101