93565-01-6 | N1,N4-Di(buta-2,3-dienyl)butane-1,4-diamine dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$48.00	$34.00
100mg	95%	in stock	$130.00	$91.00
250mg	95%	in stock	$219.00	$153.00
1g	95%	in stock	$572.00	$400.00
5g	95%	in stock	$2,313.00	$1,619.00

Description

• Catalog Number: AC82336
• Chemical Name: N1,N4-Di(buta-2,3-dienyl)butane-1,4-diamine dihydrochloride
• CAS Number: 93565-01-6
• Molecular Formula: C12H22Cl2N2
• Molecular Weight: 265.2225
• MDL Number: MFCD13152261
• SMILES: C=C=CCNCCCCNCC=C=C.Cl.Cl

Computed Properties

• Complexity: 184
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 9

Literature

• Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells.

  Amino acids 20120201

• The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury.

  American journal of physiology. Cell physiology 20100701

• Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

  Journal of cellular and molecular medicine 20100601

• A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.

  Cancer research 20091001

• Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.

  International journal of oncology 20090901

• Modulation by polyamines of apoptotic pathways triggered by procyanidins in human metastatic SW620 cells.

  Cellular and molecular life sciences : CMLS 20080501

• Identification of a novel Cys2/His2-type zinc-finger protein as a component of a spermine-signaling pathway in tobacco.

  Journal of plant physiology 20070601

• MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells.

  Biochemical Society transactions 20070401

• Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction.

  Biochemical Society transactions 20070401

• Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol.

  International journal of oncology 20061201

• Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.

  Biochimica et biophysica acta 20061001

• Sensitization of human colon adenocarcinoma cells (LoVo) to reactive oxygen species by a lysosomotropic compound.

  International journal of oncology 20061001

• Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells.

  International journal of oncology 20060801

• Interaction of bovine serum amine oxidase with the polyamine oxidase inactivator MDL 72527.

  Biochemical and biophysical research communications 20060217

• Synergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention.

  Anticancer research 20060101

• Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue.

  International journal of oncology 20051201

• Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527.

  Biochemical and biophysical research communications 20050114

• Mouse spermine oxidase: a model of the catalytic cycle and its inhibition by N,N1-bis(2,3-butadienyl)-1,4-butanediamine.

  Biochemical and biophysical research communications 20040910

• How important is the oxidative degradation of spermine?: minireview article.

  Amino acids 20040701

• Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.

  The Journal of biological chemistry 20040625

• Contribution of spermidine to stimulation by hepatocyte growth factor in repair after damage of rabbit gastric mucosal cells in primary culture.

  Biochimica et biophysica acta 20030120

• Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020501

• The polyamine oxidase inactivator MDL 72527.

  Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20020101

• Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620.

  Cell biology and toxicology 20020101

• Role of polyamine metabolism in kainic acid excitotoxicity in organotypic hippocampal slice cultures.

  Journal of neurochemistry 20011201

• Rapid induction of apoptosis by deregulated uptake of polyamine analogues.

  The Biochemical journal 19971115