937272-79-2 | (16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$32.00	$22.00
2mg	97%	in stock	$42.00	$29.00
5mg	97%	in stock	$75.00	$52.00
10mg	97%	in stock	$126.00	$88.00
25mg	97%	in stock	$180.00	$126.00
50mg	97%	in stock	$270.00	$189.00
100mg	97%	in stock	$406.00	$284.00

Description

• Catalog Number: AB52881
• Chemical Name: (16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene
• CAS Number: 937272-79-2
• Molecular Formula: C28H32N4O3
• Molecular Weight: 472.5787
• MDL Number: MFCD22572772
• SMILES: C1/C=C/COCc2cc(ccc2OCCN2CCCC2)Nc2nc(-c3cc(CO1)ccc3)ccn2

Computed Properties

• Complexity: 644
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 3.8

Literature

• Current outlook on molecular pathogenesis and treatment of myeloproliferative neoplasms.

  Molecular diagnosis & therapy 20121001

• JAK2 inhibitors and their impact in myeloproliferative neoplasms.

  Hematology (Amsterdam, Netherlands) 20120401

• Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritis.

  Journal of medicinal chemistry 20120322

• Novel targeted therapy for acute myeloid leukemia with a dual FLT3 and JAK2 inhibitor.

  Acta pharmacologica Sinica 20120201

• SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.

  Leukemia 20111101

• Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma.

  Journal of medicinal chemistry 20110714