944261-79-4 | A-803467

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$20.00	$14.00
5mg	≥98%	in stock	$48.00	$34.00
10mg	98%	in stock	$72.00	$51.00
50mg	98%	in stock	$150.00	$105.00

Description

• Catalog Number: AC76450
• Chemical Name: A-803467
• CAS Number: 944261-79-4
• Molecular Formula: C19H16ClNO4
• Molecular Weight: 357.7876
• MDL Number: MFCD10574689
• SMILES: COc1cc(cc(c1)OC)NC(=O)c1ccc(o1)c1ccc(cc1)Cl

Computed Properties

• Complexity: 429
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 4.4

Literature

• Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.

  Circulation research 20120720

• A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis.

  Annals of neurology 20120201

• The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.

  Anesthesia and analgesia 20120101

• Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis.

  Arthritis research & therapy 20120101

• Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons.

  Brain : a journal of neurology 20110201

• Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.

  Bioorganic & medicinal chemistry letters 20101115

• Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.

  Journal of neurochemistry 20100601

• Structural determinants of drugs acting on the Nav1.8 channel.

  The Journal of biological chemistry 20090417

• Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.

  The journal of pain : official journal of the American Pain Society 20090301

• A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.

  The Journal of pharmacology and experimental therapeutics 20080301

• Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.

  Journal of medicinal chemistry 20080214

• Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels.

  Molecular interventions 20070801

• Sodium channel blockers.

  Journal of medicinal chemistry 20070531

• A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

  Proceedings of the National Academy of Sciences of the United States of America 20070515

• Block of Nav1.8 by small molecules.

  Channels (Austin, Tex.) 20070101