945-24-4 | 2,4-Diamino-6-(hydroxymethyl)pteridine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$19.00	$14.00
5g	95%	in stock	$53.00	$37.00
25g	95%	in stock	$145.00	$102.00
100g	95%	in stock	$375.00	$263.00

Description

• Catalog Number: AB43651
• Chemical Name: 2,4-Diamino-6-(hydroxymethyl)pteridine
• CAS Number: 945-24-4
• Molecular Formula: C7H8N6O
• Molecular Weight: 192.1780
• MDL Number: MFCD00006711
• SMILES: OCc1cnc2c(n1)c(N)nc(n2)N

Computed Properties

• Complexity: 203
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1
• XLogP3: -1.7

Literature

• Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness.

  PloS one 20110101

• Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model.

  Experimental parasitology 20081101

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Determination of the chiral and achiral related substances of methotrexate by cyclodextrin-modified micellar electrokinetic chromatography.

  Electrophoresis 20040801

• Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer.

  Photochemistry and photobiology 20021101

• Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.

  Journal of medicinal chemistry 20010719

• Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.

  Journal of medicinal chemistry 19990826