95-25-0 | 5-Chlorobenzo[d]oxazol-2-ol

Packsize	Purity	Availability	Price	Discounted Price
25g	98%	in stock	$12.00	$8.00

Description

• Catalog Number: AB45280
• Chemical Name: 5-Chlorobenzo[d]oxazol-2-ol
• CAS Number: 95-25-0
• Molecular Formula: C7H4ClNO2
• Molecular Weight: 169.5652
• MDL Number: MFCD00005717
• SMILES: Clc1ccc2c(c1)[nH]c(=O)o2

Computed Properties

• Complexity: 185
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.8

Literature

• Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.

  Archives of toxicology 20180101

• Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine.

  Chemico-biological interactions 20170601

• A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.

  Toxicology and applied pharmacology 20160201

• Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.

  Toxicology letters 20160122

• Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.

  Toxicology letters 20150716

• Metabolic characterization of cell systems used in in vitro toxicology testing: lung cell system BEAS-2B as a working example.

  Toxicology in vitro : an international journal published in association with BIBRA 20130901

• The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches.

  Toxicology in vitro : an international journal published in association with BIBRA 20130801

• Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.

  Journal of neurophysiology 20130515

• Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.

  Journal of applied toxicology : JAT 20130201

• Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem.

  Toxicology 20121216

• Application of an innovative design space optimization strategy to the development of liquid chromatographic methods to combat potentially counterfeit nonsteroidal anti-inflammatory drugs.

  Journal of chromatography. A 20121109

• Cerebellar ataxia by enhanced Ca(V)2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1a(S218L) mutant mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20121031

• Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms.

  Journal of chromatographic science 20121001

• In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates.

  The Journal of pharmacy and pharmacology 20121001

• Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents.

  Arzneimittel-Forschung 20120701

• Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

  Journal of medicinal chemistry 20120524

• CYP2E1 phenotype in Mexican workers occupationally exposed to low levels of toluene.

  Toxicology letters 20120425

• Diffusion of counterfeit drugs in developing countries and stability of galenics stored for months under different conditions of temperature and relative humidity.

  Croatian medical journal 20120401

• Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120315

• Spectrofluorimetric assessment of chlorzoxazone and ibuprofen in pharmaceutical formulations by using Eu-tetracycline HCl optical sensor doped in sol-gel matrix.

  Journal of fluorescence 20120301

• Molecular dynamics simulations of CYP2E1.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20120301

• Fluorescence detection of ligand binding to labeled cytochrome P450 BM3.

  Dalton transactions (Cambridge, England : 2003) 20120221

• Metabolic capabilities of cytochrome P450 enzymes in Chinese liver microsomes compared with those in Caucasian liver microsomes.

  British journal of clinical pharmacology 20120201

• Muscle relaxants for pain management in rheumatoid arthritis.

  The Cochrane database of systematic reviews 20120118

• Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs.

  Journal of ethnopharmacology 20120106

• CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases.

  International journal of hepatology 20120101

• Immunological response as a source to variability in drug metabolism and transport.

  Frontiers in pharmacology 20120101

• Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo.

  Journal of Asian natural products research 20120101

• Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations.

  PloS one 20120101

• Plastics and carcinogenesis: The example of vinyl chloride.

  Journal of carcinogenesis 20120101

• An overview of the evidence and mechanisms of herb-drug interactions.

  Frontiers in pharmacology 20120101

• Genetic polymorphisms in CYP2E1: association with schizophrenia susceptibility and risperidone response in the Chinese Han population.

  PloS one 20120101

• K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration.

  Frontiers in pharmacology 20120101

• [Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

• Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats.

  Biomedical research (Tokyo, Japan) 20120101

• Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats.

  Journal of pharmaceutical sciences 20111201

• Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys.

  Drug metabolism and disposition: the biological fate of chemicals 20111201

• Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism.

  Drug metabolism and disposition: the biological fate of chemicals 20111201

• Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.

  Clinical pharmacokinetics 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: focusing on CYP2A6.

  Chemico-biological interactions 20111115

• Identification of the human liver cytochrome P450 isoenzymes responsible for the 5-methylhydroxylation of the novel anti-fibrotic drug AKF-PD.

  Xenobiotica; the fate of foreign compounds in biological systems 20111001

• Benefit of using muscle relaxants in the routine treatment protocol of oral submucosal fibrosis: a pilot study.

  Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20111001

• The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1.

  Chemico-biological interactions 20110815

• In vitro inhibitory effects of Wen-pi-tang-Hab-Wu-ling-san on human cytochrome P450 isoforms.

  Journal of clinical pharmacy and therapeutics 20110801

• Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus.

  British journal of pharmacology 20110701

• Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.

  Drug metabolism and pharmacokinetics 20110601

• In vitro inhibition of porcine cytochrome P450 by 17β -estradiol and 17α-estradiol.

  Interdisciplinary toxicology 20110601

• Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats.

  Biological psychiatry 20110401

• KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.

  Cell death & disease 20110401

• A UPLC-MS/MS assay of the 'Pittsburgh cocktail': six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution.

  The Analyst 20110207

• Determination of brain cytochrome P450 2E1 activity in rat with the probe of chlorzoxazone by liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110201

• Screening of conditions controlling spectrophotometric sequential injection analysis.

  Chemistry Central journal 20110101

• Fluorescence Spectrometric Determination of Drugs Containing α-Methylene Sulfone/Sulfonamide Functional Groups Using N-Methylnicotinamide Chloride as a Fluorogenic Agent.

  International journal of analytical chemistry 20110101

• The SK channel as a novel target for treating alcohol use disorders.

  Channels (Austin, Tex.) 20110101

• Network neighbors of drug targets contribute to drug side-effect similarity.

  PloS one 20110101

• Drug use in elderly patients: Are we there yet?

  Journal of pharmacology & pharmacotherapeutics 20110101

• Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y.

  Chemistry Central journal 20110101

• Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats.

  Pharmacognosy research 20110101

• Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form.

  Indian journal of pharmaceutical sciences 20110101

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

  Healthcare informatics research 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Screening and quantitative determination of twelve acidic and neutral pharmaceuticals in whole blood by liquid-liquid extraction and liquid chromatography-tandem mass spectrometry.

  Journal of analytical toxicology 20100901

• Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling.

  International journal of environmental research and public health 20100901

• Small scale screening to determine the ability of different polymers to inhibit drug crystallization upon rapid solvent evaporation.

  Molecular pharmaceutics 20100802

• Basolateral Cl- uptake mechanisms in Xenopus laevis lung epithelium.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100701

• Pharmacologic management of chronic pain.

  The Korean journal of pain 20100601

• KCa channels as therapeutic targets in episodic ataxia type-2.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526

• The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526

• Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.

  Drug metabolism and disposition: the biological fate of chemicals 20100501

• Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5.

  Drug metabolism and disposition: the biological fate of chemicals 20100501

• Effect of buagafuran on liver microsomal cytochrome P450 in rats.

  Journal of Asian natural products research 20100501

• Inhibition of human liver microsomal CYP by nateglinide.

  The Journal of pharmacy and pharmacology 20100501

• Human CYP2E1 is regulated by miR-378.

  Biochemical pharmacology 20100401

• Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats.

  Planta medica 20100201

• Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms.

  Toxicological sciences : an official journal of the Society of Toxicology 20100201

• Exposure of the U.S. population to acrylamide in the National Health and Nutrition Examination Survey 2003-2004.

  Environmental health perspectives 20100201

• Effects of nicotine on cytochrome P450 2A6 and 2E1 activities.

  British journal of clinical pharmacology 20100201

• In vivo CYP2E1 phenotyping as a new potential biomarker of occupational and experimental exposure to benzene.

  Toxicology letters 20100115

• Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tools, and possible solutions.

  Clinical interventions in aging 20100101

• Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.

  BMC genomics 20100101

• Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

  Bioorganic & medicinal chemistry letters 20091201

• [Role of physical therapy in the treatment of gonarthrosis].

  La Revue du praticien 20091120

• Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels.

  Biopharmaceutics & drug disposition 20091101

• Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats.

  Toxicology 20091029

• Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers.

  Basic & clinical pharmacology & toxicology 20091001

• Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver.

  European journal of pharmacology 20090815

• [Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

• The mechanism of the rat liver cytochrome P4502E1 inhibition by the synthetic prostanoids of A-type.

  Prostaglandins & other lipid mediators 20090601

• Evidence that humans metabolize benzene via two pathways.

  Environmental health perspectives 20090601

• Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: design, synthesis, pharmacological investigations and docking studies.

  Bioorganic & medicinal chemistry 20090515

• Ion channel modulators mediated alterations in NO-induced free radical generation and neutrophil membrane potential.

  Free radical research 20090501

• Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1.

  Journal of cell science 20090415

• A simplified method to determine five cytochrome p450 probe drugs by HPLC in a single run.

  Biological & pharmaceutical bulletin 20090401

• Effects of rifampin on CYP2E1-dependent hepatotoxicity of isoniazid in rats.

  Pharmacological research 20090201

• In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090201

• Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.

  The Biochemical journal 20090101

• Interactions between herbal medicines and prescribed drugs: an updated systematic review.

  Drugs 20090101

• Chlorzoxazone hydroxylation in microsomes and hepatocytes from cytochrome P450 oxidoreductase-null mice.

  Journal of biochemical and molecular toxicology 20090101

• Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column.

  Journal of chromatography. A 20081226

• K(+)-channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neurons.

  Journal of pharmacological sciences 20081201

• Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

  The Journal of biological chemistry 20081114

• Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081101

• Deleterious effects induced by oxidative stress in liver nuclei from rats receiving an alcohol-containing liquid diet.

  Toxicology and industrial health 20081101

• Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

  Journal of medicinal chemistry 20081009

• Human CYP2E1 mediates the formation of glycidamide from acrylamide.

  Archives of toxicology 20081001

• Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.

  Cellular and molecular life sciences : CMLS 20081001

• Cellular imaging predictions of clinical drug-induced liver injury.

  Toxicological sciences : an official journal of the Society of Toxicology 20080901

• Simultaneous determination of aceclofenac, paracetamol, and chlorzoxazone by RP-HPLC in pharmaceutical dosage form.

  Journal of chromatographic science 20080801

• [HPLC for determination of activity of serum CYP2E1].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20080801

• Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus.

  Drug metabolism and disposition: the biological fate of chemicals 20080701

• Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

  Journal of medicinal chemistry 20080612

• Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical.

  The AAPS journal 20080601

• Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs.

  Journal of ethnopharmacology 20080522

• Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080501

• High-performance liquid chromatographic analysis of resveratrol analog 3,5,4'-trimethoxystilbene in rat plasma.

  Methods and findings in experimental and clinical pharmacology 20080401

• Modulation of P450 enzymes by Cuban natural products rich in polyphenolic compounds in rat hepatocytes.

  Chemico-biological interactions 20080310

• Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene.

  Chemical research in toxicology 20080301

• [Expression of human CYP2E1 in insect cells using bac-to-bac expression system].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20080301

• The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080201

• Association of potentially inappropriate medication use with adverse outcomes in ambulatory elderly patients with chronic diseases: experience in a Taiwanese medical setting.

  Drugs & aging 20080101

• Exogenous and endogenous determinants of blood trihalomethane levels after showering.

  Environmental health perspectives 20080101

• The influence of a newly developed quinolone: antofloxacin, on CYP activity in rats.

  European journal of drug metabolism and pharmacokinetics 20080101

• Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women.

  Biological research 20080101

• Soft occlusal splint therapy in the management of myofascial pain dysfunction syndrome: a follow-up study.

  Indian journal of dental research : official publication of Indian Society for Dental Research 20080101

• Role of cytochrome P450 in drug interactions.

  Nutrition & metabolism 20080101

• Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.

  Critical care (London, England) 20080101

• Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers.

  Drug metabolism and drug interactions 20080101

• Chlorzoxazone as a cause of acute liver failure requiring liver transplantation.

  Digestive diseases and sciences 20071201

• Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity.

  Drug metabolism and disposition: the biological fate of chemicals 20071201

• Circadian rhythm of cytochrome P4502E1 and its effect on disposition kinetics of chlorzoxazone in rats.

  European journal of pharmacology 20071121

• Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes.

  Life sciences 20071027

• Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation.

  Drug metabolism and disposition: the biological fate of chemicals 20071001

• Is bupropion a more specific substrate for porcine CYP2E than chlorzoxazone and p-nitrophenol?

  Basic & clinical pharmacology & toxicology 20070901

• Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.

  Biological & pharmaceutical bulletin 20070901

• Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.

  Critical care medicine 20070901

• CFTR-dependent Cl- secretion in Xenopus laevis lung epithelium.

  Respiratory physiology & neurobiology 20070815

• Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis.

  Liver international : official journal of the International Association for the Study of the Liver 20070801

• In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies.

  Journal of mass spectrometry : JMS 20070701

• Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.

  Toxicology 20070603

• Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.

  Fundamental & clinical pharmacology 20070601

• Phenotyping of cytochrome P450 2E1 in vitro and in vivo.

  Current drug metabolism 20070601

• Expression of CYP2E1 in human nasopharynx and its metabolic effect in vitro.

  Molecular and cellular biochemistry 20070401

• Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070301

• Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium.

  Toxicology in vitro : an international journal published in association with BIBRA 20070201

• Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats.

  Biochemical pharmacology 20070101

• Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients.

  European journal of clinical pharmacology 20070101

• Simultaneous determination of paracetamol, chlorzoxazone, and related impurities 4-aminophenol, 4'-chloroacetanilide, and p-chlorophenol in pharmaceutical preparations by high-performance liquid chromatography.

  Journal of AOAC International 20070101

• The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.

  BMC medicine 20070101

• Simultaneous determination of chlorzoxazone and ketoprofen in binary mixtures and in ternary mixtures containing the chlorzoxazone degradation product by reversed-phase liquid chromatography.

  Journal of AOAC International 20070101

• A study on the pharmacokinetics of chlorzoxazone in healthy Thai volunteers.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20070101

• Pharmacokinetics of etoposide in rats with uranyl nitrate (UN)-induced acute renal failure (ARF): optimization of the duration of UN dosing.

  European journal of drug metabolism and pharmacokinetics 20070101

• Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism.

  European journal of pharmacology 20061215

• The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes.

  Life sciences 20061125

• Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h.

  Life sciences 20061102

• Pharmacokinetics of chlorzoxazone in rats with diabetes: Induction of CYP2E1 on 6-hydroxychlorzoxazone formation.

  Journal of pharmaceutical sciences 20061101

• Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women.

  Journal of clinical pharmacology 20061101

• OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.

  PLoS medicine 20061101

• Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat.

  Aquatic toxicology (Amsterdam, Netherlands) 20061025

• Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats.

  Life sciences 20061012

• Chlorzoxazone inhibits contraction of rat thoracic aorta.

  European journal of pharmacology 20060918

• Characteristics and trends of 3,4-methylenedioxymethamphetamine (MDMA) tablets found in Taiwan from 2002 to February 2005.

  Forensic science international 20060912

• In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment.

  Drug metabolism and disposition: the biological fate of chemicals 20060901

• Liver disease selectively modulates cytochrome P450--mediated metabolism.

  Clinical pharmacology and therapeutics 20060901

• Validation of incorporating flurbiprofen into the Pittsburgh cocktail.

  Clinical pharmacology and therapeutics 20060901

• Development of dosage design of hepatic metabolizing drugs using serum albumin level in chronic hepatic failure.

  Biological & pharmaceutical bulletin 20060801

• Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): comparison with human enzyme analogs.

  Comparative medicine 20060801

• Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers.

  Drug metabolism and disposition: the biological fate of chemicals 20060701

• Hepatic disposition of the cytochrome P450 2E1 marker chlorzoxazone and its hydroxylated metabolite in isolated perfused rat livers.

  Journal of pharmaceutical sciences 20060701

• Clearance of unusual muscular uptake of F-18 FDG in the lower lumbar region on a repeat FDG-PET scan after oral chlorzoxazone intervention.

  Clinical nuclear medicine 20060701

• Inhibitory effects of cytostatically active 6-aminobenzo[c]phenanthridines on cytochrome P450 enzymes in human hepatic microsomes.

  Basic & clinical pharmacology & toxicology 20060701

• Enzymatic properties of human CYP2W1 expressed in Escherichia coli.

  Biochemical and biophysical research communications 20060623

• Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences.

  Xenobiotica; the fate of foreign compounds in biological systems 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine.

  Neuropharmacology 20060401

• Induction and recovery time course of rat brain CYP2E1 after nicotine treatment.

  Drug metabolism and disposition: the biological fate of chemicals 20060401

• Occupational toluene exposure induces cytochrome P450 2E1 mRNA expression in peripheral lymphocytes.

  Environmental health perspectives 20060401

• High-performance liquid chromatography spectrometric analysis of trans-resveratrol in rat plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307

• Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model.

  Critical care medicine 20060301

• Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba.

  Journal of clinical pharmacy and therapeutics 20060201

• CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone.

  Drug metabolism and disposition: the biological fate of chemicals 20060101

• Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients.

  Hepatology research : the official journal of the Japan Society of Hepatology 20060101

• Effects of steady-state lasofoxifene on CYP2D6- and CYP2E1-mediated metabolism.

  The Annals of pharmacotherapy 20060101

• Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats.

  The Journal of pharmacy and pharmacology 20060101

• Serum aminotransferase activity as a predictor for estimation of total clearance of hepatically metabolized drugs in rats with acute hepatic failure.

  Biological & pharmaceutical bulletin 20060101

• Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe.

  Journal of clinical pharmacology 20060101

• Effects of irsogladine on P450-isoform specific activities in human hepatic microsomes.

  Arzneimittel-Forschung 20060101

• Methemoglobinemia: life-threatening hazard of multiple drug ingestions.

  Boletin de la Asociacion Medica de Puerto Rico 20060101

• Functional characterisation of an engineered multidomain human P450 2E1 by molecular Lego.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20051201

• Antitumor drug ellipticine inhibits the activities of rat hepatic cytochromes P450.

  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201

• Cytochrome P450 2E polymorphism in feline liver.

  Biochimica et biophysica acta 20051115

• In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.

  Drug metabolism and pharmacokinetics 20051001

• Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.

  Bioorganic & medicinal chemistry letters 20050915

• Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20050801

• Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20050701

• Enzyme-selective effects of nitric oxide on affinity and maximum velocity of various rat cytochromes P450.

  Drug metabolism and disposition: the biological fate of chemicals 20050601

• Minipig cytochrome P450 2E1: comparison with human enzyme.

  Drug metabolism and disposition: the biological fate of chemicals 20050601

• Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation.

  Journal of clinical pharmacology 20050601

• Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050501

• Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics.

  Hepatology (Baltimore, Md.) 20050501

• In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes.

  Clinical pharmacology and therapeutics 20050501

• [Ratio spectrophotometry and its application to assay of compound pharmacy preparations].

  Guang pu xue yu guang pu fen xi = Guang pu 20050401

• The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity.

  Drug metabolism and disposition: the biological fate of chemicals 20050301

• The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation.

  Mutagenesis 20050301

• Cytochrome P-450 activity is differentially altered in severely injured patients.

  Critical care medicine 20050301

• Comparison of cytochrome P4502E1 (CYP2E1) activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis C.

  Toxicology letters 20050115

• Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101

• Validation of a simple bioanalytical method for the determination of DRF-6196, a novel oxazolidinone, in mouse plasma: application to a single-dose pharmacokinetic study.

  Arzneimittel-Forschung 20050101

• Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba.

  Drugs & aging 20050101

• High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• Effects of etodolac on P450 isoform-specific activities in human hepatic microsomes.

  Arzneimittel-Forschung 20050101

• The effect of isoniazid containing regimen on CYP2E1 during antituberculosis therapy.

  Research communications in molecular pathology and pharmacology 20050101

• Bioequivalence revisited: influence of age and sex on CYP enzymes.

  Clinical pharmacology and therapeutics 20041201

• Comparative studies of the effects of two novel sugar drug candidates on the CYP 1A2 and CYP 2E1 enzymes in different sexed rats using a 'cocktail' approach.

  Molecules (Basel, Switzerland) 20041130

• Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities.

  Journal of pharmacological sciences 20041101

• In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.

  Clinical pharmacology and therapeutics 20041101

• Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung.

  The Journal of pharmacology and experimental therapeutics 20040901

• A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study.

  British journal of clinical pharmacology 20040901

• Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils.

  Xenobiotica; the fate of foreign compounds in biological systems 20040901

• Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.

  Xenobiotica; the fate of foreign compounds in biological systems 20040901

• Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity.

  British journal of clinical pharmacology 20040801

• Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.

  Journal of pain and symptom management 20040801

• Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation.

  Chemical research in toxicology 20040801

• Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression.

  American journal of physiology. Cell physiology 20040701

• The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.

  Drug metabolism and disposition: the biological fate of chemicals 20040701

• Validated assays for human cytochrome P450 activities.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients.

  Clinical pharmacology and therapeutics 20040601

• Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats.

  The Journal of pharmacy and pharmacology 20040601

• Presence of cytochrome P450 enzymes in human CD34+ haematopoietic progenitor cells.

  General physiology and biophysics 20040601

• Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes.

  Xenobiotica; the fate of foreign compounds in biological systems 20040501

• Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040401

• ATP release triggered by activation of the Ca2+-activated K+ channel in human airway Calu-3 cells.

  American journal of respiratory cell and molecular biology 20040301

• Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress?

  Archives of toxicology 20040301

• Phase I and II enzyme characterization of two sources of HepG2 cell lines.

  Xenobiotica; the fate of foreign compounds in biological systems 20040301

• Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.

  British journal of clinical pharmacology 20040201

• Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.

  International journal of pharmaceutics 20040128

• Characteristics and a functional implication of Ca(2+)-activated K(+) current in mouse aortic endothelial cells.

  Pflugers Archiv : European journal of physiology 20040101

• The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture.

  Drug metabolism and disposition: the biological fate of chemicals 20040101

• Annular leucocytoclastic vasculitis induced by chlorzoxazone.

  The British journal of dermatology 20040101

• Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study.

  Breast cancer research : BCR 20040101

• Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast.

  Biochemistry 20031216

• Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans.

  European journal of clinical pharmacology 20031201

• Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies.

  Clinical pharmacology and therapeutics 20031201

• 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies.

  Xenobiotica; the fate of foreign compounds in biological systems 20031201

• GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer.

  Drug metabolism and disposition: the biological fate of chemicals 20031101

• Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.

  Drug metabolism and disposition: the biological fate of chemicals 20031101

• Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.

  Clinical pharmacology and therapeutics 20031101

• CYP2E1 regulation by benzene and other small organic chemicals in rat liver and peripheral lymphocytes.

  Toxicology letters 20030915

• Simultaneous determination of aspirin and isosorbide 5-mononitrate in formulation by reversed phase high pressure liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20030821

• Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF.

  American journal of physiology. Cell physiology 20030801

• Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes.

  Toxicology in vitro : an international journal published in association with BIBRA 20030801

• CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.

  Hepatology (Baltimore, Md.) 20030801

• Effects of glucose on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.

  Journal of pharmaceutical sciences 20030801

• Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism.

  Journal of neurochemistry 20030801

• Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages.

  Life sciences 20030718

• Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.

  Life sciences 20030606

• Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20030601

• How useful is the 'cocktail approach' for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?

  Journal of clinical pharmacy and therapeutics 20030601

• Functional characterization of three human cytochrome p450 2E1 variants with amino acid substitutions.

  Xenobiotica; the fate of foreign compounds in biological systems 20030601

• Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2.

  Xenobiotica; the fate of foreign compounds in biological systems 20030601

• Cytochrome P450 expression and testosterone metabolism in the liver of deer.

  Toxicology 20030501

• Construction and assessment of models of CYP2E1: predictions of metabolism from docking, molecular dynamics, and density functional theoretical calculations.

  Journal of medicinal chemistry 20030424

• Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice.

  Drug metabolism and disposition: the biological fate of chemicals 20030401

• Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis.

  Hepatology (Baltimore, Md.) 20030401

• The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine.

  International archives of occupational and environmental health 20030401

• Kinetic study of alkaline induced hydrolysis of the skeletal muscle relaxant chlorzoxazone using ratio spectra first derivative spectrophotometry.

  Farmaco (Societa chimica italiana : 1989) 20030401

• Metabolism of chloroform in the human liver and identification of the competent P450s.

  Drug metabolism and disposition: the biological fate of chemicals 20030301

• Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.

  Hepatology (Baltimore, Md.) 20030301

• Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes.

  Biopharmaceutics & drug disposition 20030301

• Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.

  Clinical pharmacology and therapeutics 20030301

• Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome P450s.

  Analytical chemistry 20030201

• Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation.

  The Journal of biological chemistry 20030131

• Determination of 6-hydroxychlorzoxazone and chlorzoxazone in porcine microsome samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030125

• Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells.

  Brain research 20030103

• Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.

  Archives of biochemistry and biophysics 20030101

• Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans.

  British journal of clinical pharmacology 20030101

• Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel.

  In vitro cellular & developmental biology. Animal 20030101

• In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

  Drug metabolism and pharmacokinetics 20030101

• Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1.

  Alternatives to laboratory animals : ATLA 20030101

• Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs.

  Archives of toxicology 20021201

• Validated HPLC method for determination of chlorzoxazone in human serum and its application in a clinical pharmacokinetic study.

  Die Pharmazie 20021201

• Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

  Biochemistry 20021126

• Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

• Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population.

  Xenobiotica; the fate of foreign compounds in biological systems 20021101

• [Simultaneous determination of three probe drugs by reversed-phase high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20021101

• Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes.

  Biochemical pharmacology 20021001

• Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption.

  Human reproduction (Oxford, England) 20021001

• Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.

  Journal of cardiac failure 20021001

• Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress.

  Antioxidants & redox signaling 20021001

• Cytochrome P4502E1 phenotyping by the measurement of the chlorzoxazone metabolic ratio: assessment of its usefulness in workers exposed to styrene.

  International archives of occupational and environmental health 20020901

• Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans.

  Clinical pharmacology and therapeutics 20020901

• Cytochrome P450 2E1 and 3A activities do not differ between Mexicans and European Americans.

  Clinical pharmacology and therapeutics 20020901

• Watercress has no Importance for the elimination of ethanol by CYP2E1 inhibition.

  Pharmacology & toxicology 20020901

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Effect of methacrylonitrile on cytochrome P-450 2E1 (CYP2E1) expression in male F344 rats.

  Journal of toxicology and environmental health. Part A 20020412

• Effects of cysteine on the pharmacokinetics of intravenous chlorzoxazone in rats with protein-calorie malnutrition.

  Biopharmaceutics & drug disposition 20020401

• Inhibition of cytochromes P450 by antifungal imidazole derivatives.

  Drug metabolism and disposition: the biological fate of chemicals 20020301

• The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20020301

• Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.

  Biochemical pharmacology 20020301

• Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes.

  Journal of toxicology and environmental health. Part A 20020301

• Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.

  Pharmacology & toxicology 20020301

• Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.

  British journal of clinical pharmacology 20020201

• Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.

  Journal of hepatology 20020101

• Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs.

  Clinical pharmacokinetics 20020101

• Mechanism of aerobic transformation of carbon tetrachloride by poplar cells.

  Biodegradation 20020101

• Stability of cytochrome P450 enzymes in human liver samples stored in different tissue preservation buffers.

  Research communications in molecular pathology and pharmacology 20020101

• Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.

  Toxicology letters 20011215

• Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20011101

• Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver.

  The Journal of pharmacology and experimental therapeutics 20011101

• Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices.

  Journal of pineal research 20011101

• Assessment of cytochrome P450 activity by a five-drug cocktail approach.

  Clinical pharmacology and therapeutics 20011101

• In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9).

  British journal of clinical pharmacology 20011101

• An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).

  British journal of clinical pharmacology 20011101

• Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats.

  Archives of toxicology 20011101

• Cytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments.

  Toxicology letters 20011015

• The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat.

  The Journal of pharmacy and pharmacology 20011001

• Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20010901

• Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama).

  Chemico-biological interactions 20010831

• Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.

  Drug metabolism and disposition: the biological fate of chemicals 20010801

• Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.

  Drug metabolism and disposition: the biological fate of chemicals 20010801

• Expression of cytochrome P450 2E1 in normal human bronchial epithelial cells and activation by ethanol in culture.

  Archives of toxicology 20010801

• Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat.

  Human & experimental toxicology 20010801

• Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia.

  American journal of physiology. Lung cellular and molecular physiology 20010701

• The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone.

  Human & experimental toxicology 20010701

• Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine.

  Drug metabolism and disposition: the biological fate of chemicals 20010601

• Spectrofluorometric determination of ibuprofen in pharmaceutical formulations.

  Journal of pharmaceutical and biomedical analysis 20010601

• Genetic and dietary factors affecting human metabolism of 1,3-butadiene.

  Chemico-biological interactions 20010601

• Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics.

  Alcoholism, clinical and experimental research 20010601

• A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation.

  Chemico-biological interactions 20010516

• Metabolic capacity and interindividual variation in toxicokinetics of styrene in volunteers.

  Human & experimental toxicology 20010501

• Mitochondrial dysfunction by gamma-irradiation accompanies the induction of cytochrome P450 2E1 (CYP2E1) in rat liver.

  Toxicology 20010321

• In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene.

  Drug metabolism and disposition: the biological fate of chemicals 20010301

• Tissue-specific alterations in the 6-hydroxylation of chlorzoxazone following traumatic brain injury in the rat.

  Drug metabolism and disposition: the biological fate of chemicals 20010301

• Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.

  The Journal of pharmacology and experimental therapeutics 20010301

• Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney.

  Toxicological sciences : an official journal of the Society of Toxicology 20010301

• Cytochrome P450 expression and related metabolism in human buccal mucosa.

  Carcinogenesis 20010301

• Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.

  Xenobiotica; the fate of foreign compounds in biological systems 20010301

• Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia.

  British journal of pharmacology 20010201

• Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20010201

• One hundred percent online identity check of pharmaceutical products by near-infrared spectroscopy on the packaging line.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20010101

• Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms in ringed and grey seals from the Baltic Sea and reference sites.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010101

• High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1.

  Rapid communications in mass spectrometry : RCM 20010101

• EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes.

  Pflugers Archiv : European journal of physiology 20010101

• In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.

  British journal of clinical pharmacology 20000401

• Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels.

  American journal of physiology. Cell physiology 20000301

• [Rhabdomyolysis and cholestatic hepatitis under treatment with simvastatin and chlorzoxazone].

  Schweizerische medizinische Wochenschrift 19990403

• Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression.

  Archives of toxicology 19990201

• CYP2E1-dependent benzene toxicity: the role of extrahepatic benzene metabolism.

  Archives of toxicology 19990101

• [Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage].

  Praxis 19981007

• Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype.

  Pharmacogenetics 19981001

• Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes.

  Chemico-biological interactions 19980814

• Identification of CYP2E1 in marmoset monkey.

  Biochimica et biophysica acta 19980217

• Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.

  The Journal of pharmacology and experimental therapeutics 19980201

• Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone.

  Cancer research 19970715

• In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians.

  The Journal of pharmacology and experimental therapeutics 19961001

• Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene.

  The Journal of pharmacology and experimental therapeutics 19960101

• Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes.

  Toxicology and applied pharmacology 19950501

• Renal tumorigenicity of 1,1-dichloroethene in mice: the role of male-specific expression of cytochrome P450 2E1 in the renal bioactivation of 1,1-dichloroethene.

  Toxicology and applied pharmacology 19950101

• Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.

  Molecular pharmacology 19920201

• Chlorzoxazone-induced spasmotic torticollis.

  JAMA 19811204