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Chlorine atom substitution influences radical scavenging activity of 6-chromanol.
Bioorganic & medicinal chemistry 20120701
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How lipid unsaturation, peroxyl radical partitioning, and chromanol lipophilic tail affect the antioxidant activity of α-tocopherol: direct visualization via high-throughput fluorescence studies conducted with fluorogenic α-tocopherol analogues.
Journal of the American Chemical Society 20120620
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Is the chromanol head group of vitamin E nature's final truth on chain-breaking antioxidants?
FEBS letters 20120323
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Potassium 2,2,5,7,8-pentamethylchroman-6-oxide: a rationally designed base for Pd-catalysed amination.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120116
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Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 20111201
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6-Hy-droxy-2,5,7,8-tetra-methyl-3,4-dihydro-2H-1-benzopyran-2-carbonitrile, from synchrotron data.
Acta crystallographica. Section E, Structure reports online 20110801
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Toxic metabolite formation from Troglitazone (TGZ): new insights from a DFT study.
Chemical research in toxicology 20110718
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On the way to understand antioxidants: chromanol and dimethoxyphenols gas-phase acidities.
Journal of mass spectrometry : JMS 20110701
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2,2,5,7,8-Penta-methyl-chroman-6-yl 2,3,4,6-tetra-O-acetyl-α-d-glucopyran-oside from synchrotron data.
Acta crystallographica. Section E, Structure reports online 20110301
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Hypothyroidism of gene-targeted mice lacking Kcnq1.
Pflugers Archiv : European journal of physiology 20110101
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Chromanol derivatives--a novel class of CETP inhibitors.
Bioorganic & medicinal chemistry letters 20110101
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Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells.
Biological & pharmaceutical bulletin 20110101
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Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation.
Journal of clinical biochemistry and nutrition 20110101
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Chromanols from Sargassum siliquastrum and their antioxidant activity in HT 1080 cells.
Chemical & pharmaceutical bulletin 20110101
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Analysis of lipid content and quality in Arabidopsis plastids.
Methods in molecular biology (Clifton, N.J.) 20110101
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Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function.
Free radical biology & medicine 20101130
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Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 and JAK2 phosphorylation.
Free radical biology & medicine 20100901
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Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: the pivotal role of PKC-α translocation.
Pharmaceutical biology 20100801
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Assessment of oral toxicity and safety of pentamethylchromanol (PMCol), a potential chemopreventative agent, in rats and dogs.
Toxicology 20100629
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Synthesis and characterization of BODIPY-alpha-tocopherol: a fluorescent form of vitamin E.
The Journal of organic chemistry 20100507
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Asymmetric synthesis of alpha-tocopherol.
Chemistry (Weinheim an der Bergstrasse, Germany) 20100125
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In-vitro and in-vivo metabolic studies of the candidate chemopreventative pentamethylchromanol using liquid chromatography/tandem mass spectrometry.
The Journal of pharmacy and pharmacology 20091001
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Organocatalytic asymmetric Friedel-Crafts alkylation/cyclization cascade reaction of 1-naphthols and alpha,beta-unsaturated aldehydes: an enantioselective synthesis of chromanes and dihydrobenzopyranes.
The Journal of organic chemistry 20090904
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Impact of glucose concentration on cardiac ventricular repolarization under I Kr/I Ks blocking agents.
Journal of molecular and cellular cardiology 20090801
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Glycosidic moiety changes the spectroscopic properties of dl-alpha-tocopherol in DMSO/water solution and in organic solvents.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090715
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Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity.
European journal of medicinal chemistry 20090601
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In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes.
Chemico-biological interactions 20090515
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Phenol-based lipophilic fluorescent antioxidant indicators: a rational approach.
The Journal of organic chemistry 20090515
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Cholesterol-mediated activation of P-glycoprotein: distinct effects on basal and drug-induced ATPase activities.
Journal of pharmaceutical sciences 20090501
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Chain-breaking antioxidant activity of reduced forms of mitochondria-targeted quinones, a novel type of geroprotectors.
Aging 20090501
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Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells.
Cytotechnology 20090401
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Effects of nitric oxide donor antioxidants containing the phenol vitamin E substructure and a furoxan moiety on ischemia/reperfusion injury.
Arzneimittel-Forschung 20090101
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[Highly effective test-system for determination of the total antioxidant activity of human blood serum].
Biomeditsinskaia khimiia 20090101
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The specificity of neuroprotection by antioxidants.
Journal of biomedical science 20090101
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Diastereoselective synthesis of alpha-tocopherol: a new concept for the formation of chromanols.
Organic letters 20081120
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Tocochromanols, plastoquinol, and other biological prenyllipids as singlet oxygen quenchers-determination of singlet oxygen quenching rate constants and oxidation products.
Free radical biology & medicine 20080915
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Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.
Journal of pharmacological and toxicological methods 20080101
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A theoretical investigation on the geometry and vibrational spectra of 10,10,2,6,5-pentamethyl-1-hydroxychroman: a model of alpha-tocopherol.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071231
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The effect of the lipophilic cation lucigenin on mitochondria depends on the site of its reduction.
Biochemical pharmacology 20070815
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Calculation of the relative acidities and oxidation potentials of para-substituted phenols. A model for alpha-tocopherol in solution.
Organic & biomolecular chemistry 20070607
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Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter.
Molecular pharmacology 20070601
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Generation of superoxide and singlet oxygen from alpha-tocopherolquinone and analogues.
Free radical research 20070601
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Identification and quantitation of novel vitamin E metabolites, sulfated long-chain carboxychromanols, in human A549 cells and in rats.
Journal of lipid research 20070501
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Modulation of ERG channels by XE991.
Basic & clinical pharmacology & toxicology 20070501
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Advantages and limitation of BODIPY as a probe for the evaluation of lipid peroxidation and its inhibition by antioxidants in plasma.
Bioorganic & medicinal chemistry letters 20070401
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Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions.
Biochemical pharmacology 20070301
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Kinetic and thermochemical study of the antioxidant activity of sulfur-containing analogues of vitamin E.
Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
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Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.
Biochimica et biophysica acta 20061001
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A pharmacological action of vitamin E unrelated to its antioxidant capacity.
Methods and findings in experimental and clinical pharmacology 20061001
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Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).
Assay and drug development technologies 20060801
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Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials.
Cardiovascular research 20060601
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NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties.
Journal of medicinal chemistry 20060518
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Formation of singlet oxygen from solutions of vitamin E.
Free radical research 20060301
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A biomimetic chromanol cyclization leading to alpha-tocopherol.
Angewandte Chemie (International ed. in English) 20060206
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Transformation of alpha-tocopherol (vitamin E) and related chromanol model compounds into their phenoxonium ions by chemical oxidation with the nitrosonium cation.
The Journal of organic chemistry 20051209
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The protection of bioenergetic functions in mitochondria by new synthetic chromanols.
Biochemical pharmacology 20051101
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Prooxidant and antioxidant activity of vitamin E analogues and troglitazone.
Chemical research in toxicology 20051001
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Antioxidant properties of natural and synthetic chromanol derivatives: study by fast kinetics and electron spin resonance spectroscopy.
The Journal of organic chemistry 20050429
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Electron-transfer mechanism in radical-scavenging reactions by a vitamin E model in a protic medium.
Organic & biomolecular chemistry 20050221
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Role of nitric oxide in Ca2+ sensitivity of the slowly activating delayed rectifier K+ current in cardiac myocytes.
Circulation research 20050107
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Both beta-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of I(Ks) channel blockers in vitro.
Journal of pharmacological and toxicological methods 20050101
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Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.
Bioorganic & medicinal chemistry letters 20041220
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13C CP/MAS NMR studies of vitamin E model compounds.
Magnetic resonance in chemistry : MRC 20041001
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Kinetic studies on stilbazulenyl-bis-nitrone (STAZN), a nonphenolic chain-breaking antioxidant in solution, micelles, and lipid membranes.
The Journal of organic chemistry 20040430
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Inhibitory mechanisms of YC-1 and PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages.
Biochemical pharmacology 20040401
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Alpha-tocopherol influences the lipid membrane affinity of desipramine in a pH-dependent manner.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040201
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Soft ionization mass spectrometry of chromanols produces radical cation molecular ions.
European journal of mass spectrometry (Chichester, England) 20040101
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Kinetic study of the electron-transfer oxidation of the phenolate anion of a vitamin E model by molecular oxygen generating superoxide anion in an aprotic medium.
Organic & biomolecular chemistry 20031121
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Blockers of the slowly delayed rectifier potassium IKs channel: potential antiarrhythmic agents.
Current medicinal chemistry. Cardiovascular and hematological agents 20031001
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Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol in human prostate carcinoma cells.
Molecular cancer therapeutics 20030801
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Antioxidant effects of phytosterol and its components.
Journal of nutritional science and vitaminology 20030801
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Transmural heterogeneity of the action potential configuration in the feline left ventricle.
Circulation journal : official journal of the Japanese Circulation Society 20030501
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Diesel exhaust particle-induced cell death of cultured normal human bronchial epithelial cells.
Biological & pharmaceutical bulletin 20030401
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Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.
Biochimica et biophysica acta 20030317
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Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain.
Free radical research 20021101
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Naphthalene diols: a new class of antioxidants intramolecular hydrogen bonding in catechols, naphthalene diols, and their aryloxyl radicals.
The Journal of organic chemistry 20020726
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Antithrombotic effect of PMC, a potent alpha-tocopherol analogue on platelet plug formation in vivo.
British journal of haematology 20020601
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Reduction of 8a-hydroxy-2,2,5,7,8-pentamethyl-6-chromanone.
Redox report : communications in free radical research 20020101
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Cellular basis for complex T waves and arrhythmic activity following combined I(Kr) and I(Ks) block.
Journal of cardiovascular electrophysiology 20011201
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Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.
Drug metabolism and disposition: the biological fate of chemicals 20011101
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Ionic basis for membrane potential changes induced by hypoosmotic stress in guinea-pig ventricular myocytes.
Cardiovascular research 20010701
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Diesel exhaust particle-induced cell death of human leukemic promyelocytic cells HL-60 and their variant cells HL-NR6.
Biological & pharmaceutical bulletin 20010401
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Co-oxidation of 2,2,5,7,8-pentamethyl-6-chromanol and diphenyl disulfide with 3-chloroperoxybenzoic acid.
Redox report : communications in free radical research 20010101
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Antioxidant activity of 5-alkoxymethyl-6-chromanols.
Redox report : communications in free radical research 20010101
