951671-92-4 | 14-Azido-3,6,9,12-tetraoxatetradecan-1-ylamine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$76.00	$54.00
5g	95%	in stock	$310.00	$217.00
10g	95%	in stock	$549.00	$384.00
25g	95%	in stock	$914.00	$640.00

Description

• Catalog Number: AI63970
• Chemical Name: 14-Azido-3,6,9,12-tetraoxatetradecan-1-ylamine
• CAS Number: 951671-92-4
• Molecular Formula: C10H22N4O4
• Molecular Weight: 262.30608000000007
• MDL Number: MFCD20134134
• SMILES: NCCOCCOCCOCCOCCN=[N+]=[N-]

Computed Properties

• Complexity: 212
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 14
• XLogP3: -0.4

Upstream Synthesis Route

To synthesize 14-Azido-3,6,9,12-tetraoxatetradecan-1-ylamine, commence with the starting material of tetraethylene glycol. Protect the hydroxyl groups through a silylation reaction using tert-butyldimethylsilyl chloride (TBDMS-Cl) in the presence of imidazole as the base, and purify the resultant silyl ether.

Next, conduct a mono-tosylation of the protected tetraethylene glycol using p-toluenesulfonyl chloride (TsCl) with a base such as triethylamine (Et3N) to yield the monotosylate, while keeping the reaction conditions mild enough to prevent ditosylation. Purify the monotosylated compound accordingly.

Subsequently, replace the tosyl group with an azide group via nucleophilic substitution using sodium azide (NaN3) in a suitable solvent, such as dimethyl sulfoxide (DMSO), maintaining the temperature to prevent any potential decomposition of azide.

Finally, remove the silyl protecting groups using an acid such as hydrochloric acid (HCl) in a mixture of tetrahydrofuran (THF) and water to obtain the desired 14-Azido-3,6,9,12-tetraoxatetradecan-1-ylamine. Purification can be performed through standard chromatographic techniques to yield the target compound at an appropriate level of purity for downstream applications.