956014-19-0 | 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$42.00	$29.00
5mg	95%	in stock	$129.00	$90.00
10mg	95%	in stock	$197.00	$138.00
25mg	95%	in stock	$441.00	$309.00
50mg	95%	in stock	$757.00	$530.00
100mg	95%	in stock	$862.00	$603.00

Description

• Catalog Number: AB47617
• Chemical Name: 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea
• CAS Number: 956014-19-0
• Molecular Formula: C16H9BrF6N6S
• Molecular Weight: 511.2423
• MDL Number: MFCD24387114
• SMILES: S=C(Nc1ccc(cc1c1nn[nH]n1)Br)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F

Computed Properties

• Complexity: 586
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: 4.8

Upstream Synthesis Route

The compound Thiourea, N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]- is a versatile and valuable tool in chemical synthesis. Due to its unique structure and reactivity, it is commonly used as a reagent in various synthetic reactions. One of its significant applications is in the formation of complex organic molecules through multi-step synthesis processes. This compound serves as a key building block for the creation of diverse chemical structures, making it an essential component in the toolkit of synthetic chemists. Additionally, its specific functional groups enable selective reactions and the introduction of important pharmacophores, making it particularly useful in the development of pharmaceutical compounds and agrochemicals. In summary, Thiourea, N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]- plays a crucial role in advancing chemical synthesis techniques and expanding the possibilities of molecule design.

Literature

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  Neuroscience 20100602

• Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo.

  Naunyn-Schmiedeberg's archives of pharmacology 20100301

• BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100201

• NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats.

  British journal of pharmacology 20091101

• Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury.

  Pflugers Archiv : European journal of physiology 20090301

• The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.

  Molecular pharmacology 20071001