956697-53-3 | Nvp-lde225

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$18.00	$12.00
25mg	95%	in stock	$40.00	$28.00
100mg	95%	in stock	$116.00	$81.00
250mg	95%	in stock	$193.00	$135.00
1g	95%	in stock	$487.00	$341.00
5g	95%	in stock	$1,745.00	$1,221.00

Description

• Catalog Number: AB52128
• Chemical Name: Nvp-lde225
• CAS Number: 956697-53-3
• Molecular Formula: C26H26F3N3O3
• Molecular Weight: 485.4981
• MDL Number: MFCD16038928
• SMILES: C[C@@H]1O[C@H](C)CN(C1)c1ccc(cn1)NC(=O)c1cccc(c1C)c1ccc(cc1)OC(F)(F)F

Computed Properties

• Complexity: 691
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 5.8

Literature

• Sonidegib: First Global Approval.

  Drugs 20150901

• Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers.

  Cancer chemotherapy and pharmacology 20140701

• Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

  Nature medicine 20140701

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.

  Bioorganic & medicinal chemistry 20121115

• Smoothened antagonists reverse taxane resistance in ovarian cancer.

  Molecular cancer therapeutics 20120701

• Hedgehog inhibition with the orally bioavailable Smo antagonist LDE225 represses tumor growth and prolongs survival in a transgenic mouse model of islet cell neoplasms.

  Annals of surgery 20111101

• Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor.

  The Journal of investigative dermatology 20110801

• Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists.

  Cancer research 20110801

• Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.

  ACS medicinal chemistry letters 20100610