957135-43-2 | Sm-164

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$242.00	$170.00

Description

• Catalog Number: AX51327
• Chemical Name: Sm-164
• CAS Number: 957135-43-2
• Molecular Formula: C62H84N14O6
• Molecular Weight: 1121.4205600000007
• MDL Number: MFCD28167763
• SMILES: CN[C@H](C(=O)N[C@H]1CCCC[C@@H]2N(C1=O)[C@@H](CC2)C(=O)N[C@H](c1nnn(c1)CCCCc1ccc(cc1)CCCCn1nnc(c1)[C@H](c1ccccc1)NC(=O)[C@@H]1CC[C@H]2N1C(=O)[C@H](CCCC2)NC(=O)[C@@H](NC)C)c1ccccc1)C

Computed Properties

• Complexity: 1930
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 10
• Heavy Atom Count: 82
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 24
• XLogP3: 5.8

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.

  Bioorganic & medicinal chemistry 20121115

• Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis.

  Breast cancer research and treatment 20120501

• LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling.

  Cancer research 20120301

• Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases.

  Molecular cancer therapeutics 20110401