96-09-3 | Styrene oxide

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$25.00	$18.00
25g	97%	in stock	$36.00	$25.00
100g	97%	in stock	$90.00	$63.00
500g	97%	in stock	$251.00	$176.00

Description

• Catalog Number: AB47054
• Chemical Name: Styrene oxide
• CAS Number: 96-09-3
• Molecular Formula: C8H8O
• Molecular Weight: 120.1485
• MDL Number: MFCD00005121
• SMILES: O1CC1c1ccccc1

Computed Properties

• Complexity: 94.7
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.6

Literature

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  Toxicology 20050131

• Styrene oxide DNA adducts: quantitative determination using 31P monitoring.

  Analytical and bioanalytical chemistry 20050101

• Review of the in vivo genotoxicity tests performed with styrene.

  Mutation research 20050101

• Purification and characterization of a yeast carbonyl reductase for synthesis of optically active (R)-styrene oxide derivatives.

  Bioscience, biotechnology, and biochemistry 20050101

• Size control of styrene oxide-ethylene oxide diblock copolymer aggregates with classical surfactants: DLS, TEM, and ITC study.

  Biomacromolecules 20050101

• A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics.

  Chemical research in toxicology 20041201

• Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons.

  Toxicology 20040901

• Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component flavin-diffusible monooxygenase.

  Journal of bacteriology 20040801

• Direct electrochemiluminescence detection of oxidized DNA in ultrathin films containing [Os(bpy)2(PVP)10]2+.

  Journal of the American Chemical Society 20040721

• Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice.

  Journal of toxicology and environmental health. Part A 20040625

• Gelation of concentrated micellar solutions of a triblock copolymer of ethylene oxide and styrene oxide, S5E45S5.

  Langmuir : the ACS journal of surfaces and colloids 20040511

• An efficient synthesis of 2-amino alcohols by silica gel catalysed opening of epoxide rings by amines.

  Organic & biomolecular chemistry 20040507

• Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide.

  Toxicology letters 20040502

• Donor ligand effect on the nature of the oxygenating species in Mn(III)(salen)-catalyzed epoxidation of olefins: experimental evidence for multiple active oxidants.

  Inorganic chemistry 20040419

• Unique reactions of glycosyl iodides with oxa- and thiocycloalkane acceptors.

  Organic letters 20040318

• Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3.

  Journal of biomolecular screening 20040301

• Mechanistic approaches for evaluating the toxicity of reactive organochlorines and epoxides in green algae.

  Environmental toxicology and chemistry 20040301

• Two-sample scale tests for comparison of metabolic rates for styrene in previously exposed and unexposed groups.

  Statistics in medicine 20040227

• Enantioselective hydrolysis of various substituted styrene oxides with Aspergillus Niger CGMCC 0496.

  Organic & biomolecular chemistry 20040207

• A recombinant model for assessing the role of GSTM1 in styrene-7,8-oxide toxicity and mutagenicity.

  Toxicology 20040115

• A novel approach based on solid phase microextraction gas chromatography and mass spectrometry to the determination of highly reactive organic compounds in cells cultures: styrene oxide.

  Chemical research in toxicology 20040101

• Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers.

  Environmental and molecular mutagenesis 20040101

• Styrene-7,8-oxide.

  Report on carcinogens : carcinogen profiles 20040101

• Epoxide-opening and group-transfer reactions mediated by monomeric zirconium imido complexes.

  Journal of the American Chemical Society 20031126

• Evaluation of bioanalytical assays for toxicity assessment and mode of toxic action classification of reactive chemicals.

  Environmental science & technology 20031101

• Refinements to physiologically-based pharmacokinetic model for styrene.

  Toxicology letters 20030930

• Kinetics and mechanism of rhenium-catalyzed O atom transfer from epoxides.

  Journal of the American Chemical Society 20030910

• Voltammetric sensor for chemical toxicity using [Ru(bpy)2poly(4-vinylpyridine)10Cl)+ as catalyst in ultrathin films. DNA damage from methylating agents and an enzyme-generated epoxide.

  Analytical chemistry 20030815

• Enzymatic transformations. Immobilized A. niger epoxide hydrolase as a novel biocatalytic tool for repeated-batch hydrolytic kinetic resolution of epoxides.

  Organic & biomolecular chemistry 20030807

• Association properties of ethylene oxide/styrene oxide diblock copolymer E17S8 in aqueous solution.

  Journal of colloid and interface science 20030701

• Assessment of biotransformation of the arene moiety of styrene in volunteers and occupationally exposed workers.

  Toxicology and applied pharmacology 20030615

• Models of neurotoxicity: extrapolation of benchmark doses in vitro.

  Risk analysis : an official publication of the Society for Risk Analysis 20030601

• [Isolation of a bacterium producing epoxide hydrolase with high enantioselectivity and optimization of fermentation conditions].

  Wei sheng wu xue bao = Acta microbiologica Sinica 20030601

• Asymmetric environments in encapsulation complexes.

  Journal of the American Chemical Society 20030521

• Architecture and solution properties of amphiphilic polymer brushes with peripheral charged ions.

  Journal of colloid and interface science 20030515

• In vitro metabolism of styrene to styrene oxide in liver and lung of Cyp2E1 knockout mice.

  Journal of toxicology and environmental health. Part A 20030509

• Construction of a bacterial biosensor for styrene.

  Journal of biotechnology 20030508

• Epoxidation of styrene by human cyt P450 1A2 by thin film electrolysis and peroxide activation compared to solution reactions.

  Biophysical chemistry 20030501

• Biocatalysis of nitro substituted styrene oxides by non-conventional yeasts.

  Biotechnology letters 20030501

• Simultaneous direct electrochemiluminescence and catalytic voltammetry detection of DNA in ultrathin films.

  Journal of the American Chemical Society 20030430

• Effect of epoxide hydrolase and glutathione S-tranferase genotypes on the induction of micronuclei and DNA damage by styrene-7,8-oxide in vitro.

  Mutation research 20030420

• Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes.

  Toxicology 20030415

• Identification of residues in glutathione transferase capable of driving functional diversification in evolution. A novel approach to protein redesign.

  The Journal of biological chemistry 20030307

• Styrene-7,8-oxide activates a complex apoptotic response in neuronal PC12 cell line.

  Carcinogenesis 20030301

• A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung.

  Toxicology letters 20030218

• Toxicity screening by electrochemical detection of DNA damage by metabolites generated in situ in ultrathin DNA-enzyme films.

  Journal of the American Chemical Society 20030205

• Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage.

  Environmental and molecular mutagenesis 20030101

• A facile solid-phase synthesis of substituted 2(5H)-furanones from polymer-supported alpha-selenocarboxylic acids.

  Journal of combinatorial chemistry 20030101

• Quantitative analysis of modified proteins by LC-MS/MS of peptides labeled with phenyl isocyanate.

  Journal of proteome research 20030101

• [Definition of neurotoxic risk based on the benchmark dose in vitro: illustration with experimental models based on the use of known neurotoxic substances].

  Giornale italiano di medicina del lavoro ed ergonomia 20030101

• The repair of DNA damage induced in human peripheral lymphocytes with styrene oxide.

  Acta medica (Hradec Kralove) 20030101

• [Neurotoxic effect of 7,8-oxide styrene on striatal neuron culture].

  Giornale italiano di medicina del lavoro ed ergonomia 20030101

• Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals.

  Annals of the New York Academy of Sciences 20021201

• Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall.

  Annals of the New York Academy of Sciences 20021201

• Pilot-scale production of (S)-styrene oxide from styrene by recombinant Escherichia coli synthesizing styrene monooxygenase.

  Biotechnology and bioengineering 20021005

• Effect of the inhibition of the metabolism of 4-vinylphenol on its hepatotoxicity and pneumotoxicity in rats and mice.

  Toxicology 20020930

• Detection of cellular responses to toxicants by dielectrophoresis.

  Biochimica et biophysica acta 20020831

• Square wave voltammetric detection of chemical DNA damage with catalytic poly(4-vinylpyridine)-Ru(bpy)2(2+) films.

  Analytical chemistry 20020815

• Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans.

  Inhalation toxicology 20020801

• Oxiranyl anion-mediated synthesis of highly enantiomerically enriched styrene oxide derivatives.

  Organic letters 20020711

• Spectrum of styrene-induced DNA adducts: the relationship to other biomarkers and prospects in human biomonitoring.

  Mutation research 20020701

• Activation of microsomal epoxide hydrolase by interaction with cytochromes P450: kinetic analysis of the association and substrate-specific activation of epoxide hydrolase function.

  Archives of biochemistry and biophysics 20020615

• Sequence mapping of epoxide adducts in human hemoglobin with LC-tandem MS and the SALSA algorithm.

  Chemical research in toxicology 20020601

• Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites.

  Regulatory toxicology and pharmacology : RTP 20020601

• Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytes.

  Carcinogenesis 20020501

• Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells.

  Brain research 20020412

• DNA adducts of styrene-7,8-oxide in target and non-target organs for tumor induction in rat and mouse after repeated inhalation exposure to styrene.

  Mutation research 20020320

• Physiologically based modeling of the inhalation kinetics of styrene in humans using a bayesian population approach.

  Toxicology and applied pharmacology 20020215

• Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient air.

  Toxicology letters 20020105

• DNA damage and repair in human leukocytes exposed to styrene-7,8-oxide measured by the comet assay.

  Toxicology letters 20020105

• Structural analysis of styrene oxide/haemoglobin adducts by mass spectrometry: identification of suitable biomarkers for human exposure evaluation.

  Rapid communications in mass spectrometry : RCM 20020101

• PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol.

  BMC clinical pharmacology 20020101

• Styrene-7,8-oxide.

  Report on carcinogens : carcinogen profiles 20020101

• The role of cytochromes P-450 in styrene induced pulmonary toxicity and carcinogenicity.

  Toxicology 20011214

• Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5' nuclease assay (TaqMan).

  Mutation research 20011212

• Physiological modeling of the relative contributions of styrene-7,8-oxide derived from direct inhalation and from styrene metabolism to the systemic dose in humans.

  Toxicological sciences : an official journal of the Society of Toxicology 20011201

• Highly efficient asymmetric epoxidation of alkenes with a D(4)-symmetric chiral dichlororuthenium(IV) porphyrin catalyst.

  The Journal of organic chemistry 20011130

• Kinetics of formation of specific styrene oxide adducts in double-stranded DNA.

  Chemico-biological interactions 20011128

• Detection of chemically induced DNA damage in layered films by catalytic square wave voltammetry using Ru(bpy)3(2+).

  Analytical chemistry 20011015

• Polymorphism of xenobiotic-metabolizing enzymes and excretion of styrene-specific mercapturic acids.

  Chemical research in toxicology 20011001

• Investigation of protein-styrene oxide adducts as a molecular biomarker of human exposed to styrene.

  Journal of environmental sciences (China) 20011001

• DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation.

  Chemico-biological interactions 20010928

• The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans.

  Chemico-biological interactions 20010831

• Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction.

  Mutation research 20010822

• Metabolism of the styrene metabolite 4-vinylphenol by rat and mouse liver and lung.

  Journal of toxicology and environmental health. Part A 20010810

• Stereoselective synthesis of styrene oxides via a Mitsunobu cyclodehydration.

  Organic letters 20010809

• Stereochemical metabolism of styrene in volunteers.

  International archives of occupational and environmental health 20010701

• Determination of styrene and styrene-7,8-oxide in human blood by gas chromatography-mass spectrometry.

  Journal of chromatography. B, Biomedical sciences and applications 20010605

• Effect of mass transfer limitations on the enzymatic kinetic resolution of epoxides in a two-liquid-phase system.

  Biotechnology and bioengineering 20010405

• Genotoxic effects of styrene-7,8-oxide in human white blood cells: comet assay in relation to the induction of sister-chromatid exchanges and micronuclei.

  Mutation research 20010405

• Biotransformations catalyzed by cloned p-cymene monooxygenase from Pseudomonas putida F1.

  Applied microbiology and biotechnology 20010401

• Effects of styrene-7,8-oxide over p53, p21, bcl-2 and bax expression in human lymphocyte cultures.

  Mutagenesis 20010301

• Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity.

  Xenobiotica; the fate of foreign compounds in biological systems 20010201

• Chronic toxicity/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeks.

  Journal of applied toxicology : JAT 20010101

• Role of glutathione S-transferase mu (GSTM1) in styrene-7,8-oxide toxicity and mutagenicity.

  Environmental and molecular mutagenesis 20010101

• Sequestration of biological reactive intermediates by trapping as covalent enzyme-intermediate complex.

  Advances in experimental medicine and biology 20010101

• Stereochemistry of styrene biotransformation.

  Drug metabolism reviews 20010101

• Efficient nonmutagenic replication bypass of DNAs containing beta-adducts of styrene oxide at adenine N(6).

  Environmental and molecular mutagenesis 20010101

• Metabolism of styrene-7,8-oxide in human liver in vitro: interindividual variation and stereochemistry.

  Toxicology and applied pharmacology 20001115

• Protein adducts as dosimeters of human exposure to styrene, styrene-7,8-oxide, and benzene.

  Toxicology letters 19990905

• Styrene metabolism in Exophiala jeanselmei and involvement of a cytochrome P-450-dependent styrene monooxygenase.

  Applied and environmental microbiology 19960401

• Glutathione conjugation of microsome-mediated and synthetic aflatoxin B1-8,9-oxide by purified glutathione S-transferases from rats.

  Cancer letters 19920710

• Glutathione conjugation of styrene 7,8-oxide enantiomers by major glutathione transferase isoenzymes isolated from rat livers.

  Biochemical pharmacology 19891215