965-52-6 | Nifuroxazide

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$6.00	$4.00
50mg	98%	in stock	$7.00	$5.00
250mg	98%	in stock	$9.00	$6.00
1g	98%	in stock	$13.00	$9.00
5g	98	in stock	$25.00	$17.00
25g	98%	in stock	$54.00	$38.00
100g	98%	in stock	$173.00	$121.00
500g	98%	in stock	$603.00	$422.00

Description

• Catalog Number: AB77489
• Chemical Name: Nifuroxazide
• CAS Number: 965-52-6
• Molecular Formula: C12H9N3O5
• Molecular Weight: 275.2170
• MDL Number: MFCD00079482
• SMILES: Oc1ccc(cc1)C(=O)N/N=C/c1ccc(o1)[N+](=O)[O-]
• NSC Number: 759261

Computed Properties

• Complexity: 387
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 2.1

Literature

• Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats.

  Chemico-biological interactions 20180201

• Caco-2 cells cytotoxicity of nifuroxazide derivatives with potential activity against Methicillin-resistant Staphylococcus aureus (MRSA).

  Toxicology in vitro : an international journal published in association with BIBRA 20120401

• Synthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents.

  Bioorganic & medicinal chemistry 20111101

• [Enterofuril eradication therapy in chronic inflammatory diseases of the upper digestive tract].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Assessment of isorhamnetin 3-O-neohesperidoside from Acacia salicina: protective effects toward oxidation damage and genotoxicity induced by aflatoxin B1 and nifuroxazide.

  Journal of applied toxicology : JAT 20100801

• Polyamine reduced diet (PRD) nutrition therapy in hormone refractory prostate cancer patients.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100501

• [Eradication therapy of antibiotic-resistant strains of Helicobacter pylori].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20100101

• Design, synthesis, antimicrobial activity and molecular modeling studies of novel benzofuroxan derivatives against Staphylococcus aureus.

  Bioorganic & medicinal chemistry 20090415

• Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T. cruzi agents.

  Bioorganic & medicinal chemistry 20090401

• Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

  Blood 20081215

• A simple and sensitive spectrofluorimetric method for analysis of some nitrofuran drugs in pharmaceutical preparations.

  Journal of fluorescence 20080901

• Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides.

  Bioorganic & medicinal chemistry 20080715

• Antioxidant activity and inhibition of aflatoxin B1-, nifuroxazide-, and sodium azide-induced mutagenicity by extracts from Rhamnus alaternus L.

  Chemico-biological interactions 20080710

• Simultaneous determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by bivariate and multivariate spectral analysis.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201

• Mutagenic, antimutagenic, cytotoxic, and apoptotic activities of extracts from Pituranthos tortuosus.

  Drug and chemical toxicology 20080101

• [Topical issues of paediatric gastroenterology].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20080101

• Polyamine contents in current foods: a basis for polyamine reduced diet and a study of its long term observance and tolerance in prostate carcinoma patients.

  Amino acids 20070801

• A new class of nifuroxazide analogues: synthesis of 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus.

  Bioorganic & medicinal chemistry 20070615

• Synthesis and antigenotoxic activity of some naphtho[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives.

  European journal of medicinal chemistry 20070501

• Determination of nitrofurans in animal feeds by liquid chromatography-UV photodiode array detection and liquid chromatography-ionspray tandem mass spectrometry.

  Analytica chimica acta 20070314

• Study of antimutagenic and antioxidant activities of gallic acid and 1,2,3,4,6-pentagalloylglucose from Pistacia lentiscus. Confirmation by microarray expression profiling.

  Chemico-biological interactions 20070105

• Antigenotoxic activities of crude extracts from Acacia salicina leaves.

  Environmental and molecular mutagenesis 20070101

• Nifuroxazide-induced acute pancreatitis: a new side-effect for an old drug?

  Acta gastro-enterologica Belgica 20070101

• Organ-targeted mutagenicity of nitrofurantoin in Big Blue transgenic mice.

  Mutagenesis 20060901

• A comparative study on various spectrometries with thin layer chromatography for simultaneous analysis of drotaverine and nifuroxazide in capsules.

  Chemical & pharmaceutical bulletin 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by three independent analytical methods.

  Journal of AOAC International 20060101

• Fly agaric (Amanita muscaria) poisoning, case report and review.

  Toxicon : official journal of the International Society on Toxinology 20050601

• Anti-genotoxic and free-radical scavenging activities of extracts from (Tunisian) Myrtus communis.

  Mutation research 20041114

• Determination of attapulgite and nifuroxazide in pharmaceutical formulations by sequential digital derivative spectrophotometry.

  Journal of AOAC International 20040101

• Genotoxicity of 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000): a case study with some considerations on nitrofurantoin and nifuroxazide.

  Research in microbiology 20020901

• Potential tuberculostatic agents. Topliss application on benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazide series.

  Bioorganic & medicinal chemistry 20020301

• Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer.

  Anticancer research 20020101