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Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170901
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Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication.
Archives of toxicology 20170101
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Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases.
Chemico-biological interactions 20161125
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Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease.
Chemico-biological interactions 20160405
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The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.
Chemico-biological interactions 20130905
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Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals.
Journal of applied toxicology : JAT 20130401
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A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
Chemico-biological interactions 20130325
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Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease.
The international journal of biochemistry & cell biology 20130201
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An efficient total synthesis of (-)-huperzine A.
Organic letters 20120907
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Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
Neurochemical research 20120901
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Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901
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Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.
Drug development and industrial pharmacy 20120601
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Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model.
Toxicology mechanisms and methods 20120401
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Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.
Cold Spring Harbor perspectives in medicine 20120301
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Chiral separation of Huperzine A using CE - method validation and application in pharmaceutical formulations.
Electrophoresis 20120201
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Treatment with Huperzine A improves cognition in vascular dementia patients.
Cell biochemistry and biophysics 20120101
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Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis.
Acta pharmacologica Sinica 20120101
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Examining the interactome of huperzine A by magnetic biopanning.
PloS one 20120101
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[+]-Huperzine A protects against soman toxicity in guinea pigs.
Neurochemical research 20111201
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Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata.
Journal of industrial microbiology & biotechnology 20110901
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An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production.
Mini reviews in medicinal chemistry 20110901
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Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.
Brain research 20110715
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The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.
Neuropharmacology 20110601
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Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110401
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Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method.
Nanomedicine : nanotechnology, biology, and medicine 20110201
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Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants.
Phytochemical analysis : PCA 20110101
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Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.
Neuro endocrinology letters 20110101
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Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.
Pharmacology, biochemistry, and behavior 20101001
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Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment.
Journal of pharmaceutical and biomedical analysis 20100605
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Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers.
Chemical & pharmaceutical bulletin 20100501
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Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.
Journal of neuroscience research 20100301
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Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.
Neuroscience letters 20100205
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Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.
Pharmacology, biochemistry, and behavior 20100101
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Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
The Journal of pharmacology and experimental therapeutics 20091201
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Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
Bioorganic & medicinal chemistry 20091001
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Matrine determination and pharmacokinetics in human plasma using LC/MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001
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Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog.
Epilepsy & behavior : E&B 20090801
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Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
Nutritional neuroscience 20090801
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Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
Acta pharmacologica Sinica 20090701
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[Release mechanism of huperzine-A swelling sustained-release tablets].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701
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BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide.
European journal of pharmacology 20090624
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Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.
Free radical biology & medicine 20090601
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Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins.
Journal of chromatography. A 20090320
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Lycojapodine A, a novel alkaloid from Lycopodium japonicum.
Organic letters 20090319
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Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.
Brain, behavior, and immunity 20090101
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Huperzine A for vascular dementia.
The Cochrane database of systematic reviews 20090101
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Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids.
Journal of AOAC International 20090101
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Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
Chemico-biological interactions 20080925
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Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease.
Chemico-biological interactions 20080925
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[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
Chemico-biological interactions 20080925
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The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
Proceedings of the National Academy of Sciences of the United States of America 20080916
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Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.
Journal of neuroscience research 20080815
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Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia.
Journal of neurochemistry 20080801
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Huperzine A for Alzheimer's disease.
The Cochrane database of systematic reviews 20080416
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Determination of huperzine A in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
Biomedical chromatography : BMC 20080401
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Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method.
Journal of agricultural and food chemistry 20080213
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Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase.
Cellular and molecular neurobiology 20080201
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[Effects of huperzine A on cognitive function of rats recovering from general anesthesia].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080201
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Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats.
Cellular and molecular neurobiology 20080101
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Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.
Neurotoxicity research 20080101
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Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Neuroscience 20071205
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East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
Current Alzheimer research 20070901
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Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector.
Journal of pharmaceutical and biomedical analysis 20070509
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Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha.
Neuroreport 20070507
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Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial.
Schizophrenia research 20070501
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Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
Toxicology 20070420
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Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Toxicology 20070420
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The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.
Fitoterapia 20070401
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Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine.
Basic & clinical pharmacology & toxicology 20070301
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Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.
FEBS letters 20070220
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Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography.
Journal of chromatography. A 20070126
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Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method.
Biomedical chromatography : BMC 20070101
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Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
Current topics in medicinal chemistry 20070101
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Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Journal of medicinal chemistry 20061116
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[Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061101
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Editorial: natural products chemistry in China.
Natural product reports 20061001
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Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
Journal of neuroscience research 20060901
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Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats.
Acta pharmacologica Sinica 20060901
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Harmless herbs? Think again: merits of a complete medication history.
Journal of the American Medical Directors Association 20060901
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Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Proceedings of the National Academy of Sciences of the United States of America 20060829
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Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.
Biochemical pharmacology 20060728
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Acetylcholinesterase triggers the aggregation of PrP 106-126.
Biochemical and biophysical research communications 20060721
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Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060701
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Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Journal of medicinal chemistry 20060601
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[Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060601
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Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.
Journal of neuroscience research 20060501
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[Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim].
Wei sheng yan jiu = Journal of hygiene research 20060501
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Molecular lipophilicity determination of a huperzine series by HPLC: comparison of C18 and IAM stationary phases.
Journal of pharmaceutical and biomedical analysis 20060411
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Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS.
Journal of pharmaceutical and biomedical analysis 20060303
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Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102
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Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
Journal of peptide science : an official publication of the European Peptide Society 20060101
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Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
Acta pharmacologica Sinica 20060101
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In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid).
Chemical & pharmaceutical bulletin 20060101
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Herbal medicine in the treatment of Alzheimer's disease.
American journal of Alzheimer's disease and other dementias 20060101
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Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation.
Current medicinal chemistry 20060101
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Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
Chemico-biological interactions 20051215
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Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements.
Journal of neurochemistry 20051201
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Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.
Brain research 20051109
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A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales.
Journal of separation science 20051101
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Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
European journal of pharmacology 20050905
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Optimization of the capillary zone electrophoresis method for Huperzine A determination using experimental design and artificial neural networks.
Journal of chromatography. A 20050819
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Huperzine A--human serum albumin association: chromatographic and thermodynamic approach.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050625
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Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.
Acta pharmacologica Sinica 20050601
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Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325
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Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.
Neuroscience letters 20050221
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Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase.
Pharmacology, biochemistry, and behavior 20050101
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Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease.
Neuro-Signals 20050101
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The Lycopodium alkaloids.
Natural product reports 20041201
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(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
Journal of Alzheimer's disease : JAD 20041201
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Recent pharmacological studies on natural products in China.
European journal of pharmacology 20041001
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Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.
Neuroscience letters 20040506
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Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells.
Acta pharmacologica Sinica 20030901
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A convergent approach to huperzine A and analogues.
Organic & biomolecular chemistry 20030821
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Effects of huperzine A on liver cytochrome P-450 in rats.
Acta pharmacologica Sinica 20030801
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[Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-nor-huperzine A and its inhibitory activity of acetylcholinesterase].
Yao xue xue bao = Acta pharmaceutica Sinica 20030501
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Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons.
Neuroscience letters 20030410
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Potentiation of acetylcholine action by huperzine-A and physostigmine on some vertebrate effectors, including human iris sphincter muscle.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401
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Acute effects of huperzine A and tacrine on rat liver.
Acta pharmacologica Sinica 20030301
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Determination of huperzine A in formulated products by reversed-phase-liquid chromatography using diode array and electrospray ionization mass spectrometric detection.
Phytomedicine : international journal of phytotherapy and phytopharmacology 20030301
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Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.
European journal of pharmacology 20030214
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Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases.
Cellular and molecular neurobiology 20030201
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Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders.
Phytotherapy research : PTR 20030101
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Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
European journal of pharmacology 20021129
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Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity.
International immunopharmacology 20021001
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X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.
Biochemistry 20020903
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[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
Yao xue xue bao = Acta pharmaceutica Sinica 20020901
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Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.
Drug and chemical toxicology 20020801
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Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons.
Neuroscience letters 20020510
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Review of the value of huperzine as pretreatment of organophosphate poisoning.
Neurotoxicology 20020501
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3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Biochemistry 20020305
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Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex.
Neuroscience letters 20020215
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Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice.
Neuroscience letters 20020114
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Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation.
Journal of neuroscience research 20020101
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Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys.
European journal of pharmacology 20011221
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The NMDA receptor ion channel: a site for binding of Huperzine A.
Journal of applied toxicology : JAT 20011201
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Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
Neuroscience letters 20011109
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Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Mini reviews in medicinal chemistry 20010701
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Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
Neuroscience letters 20010622
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Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability.
Drug and chemical toxicology 20010501
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Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
Drug and chemical toxicology 20010501
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Long-term potentiation in hippocampus of rats is enhanced by endogenous acetylcholine in a way that is independent of N-methyl-D-aspartate receptors.
Neuroscience letters 20010316
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Effects of Huperzine used as pre-treatment against soman-induced seizures.
Neurotoxicology 20010201
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Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
Neuroscience 20010101
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Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
European journal of pharmacology 19980522
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Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats.
Pharmacology, biochemistry, and behavior 19950101