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Indian pacing and electrophysiology journal 20080101
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Effect of atrial electrical remodeling on the efficacy of antiarrhythmic drugs: comparison of amiodarone with I(Kr)- and I(to)/IKur-blockade in vivo.
Journal of cardiovascular electrophysiology 20071201
-
Amiodarone and atrial fibrillation.
Journal of cardiovascular electrophysiology 20071201
-
Acute conversion of persistent atrial fibrillation during dofetilide initiation.
Pacing and clinical electrophysiology : PACE 20071201
-
Optical measurements of intramural action potentials in isolated porcine hearts using optrodes.
Heart rhythm 20071101
-
Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.
The Cochrane database of systematic reviews 20071017
-
Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity.
Bioorganic & medicinal chemistry letters 20071015
-
Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects.
Laboratory animals 20071001
-
Risk factors and predictors of Torsade de pointes ventricular tachycardia in patients with left ventricular systolic dysfunction receiving Dofetilide.
The American journal of cardiology 20070901
-
Monotherapy versus combination therapy with class III antiarrhythmic agents to attenuate transmural dispersion of repolarization: a potential risk factor for torsade de pointes.
Pharmacotherapy 20070901
-
Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes.
British journal of pharmacology 20070801
-
Double pharmacological challenge on repolarization opens new avenues for drug safety research.
British journal of pharmacology 20070801
-
Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.
Biochemical pharmacology 20070801
-
Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction.
European journal of heart failure 20070801
-
Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model.
American journal of physiology. Heart and circulatory physiology 20070701
-
Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish.
Journal of leukocyte biology 20070701
-
Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat.
Cardiovascular research 20070701
-
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
Reproductive toxicology (Elmsford, N.Y.) 20070701
-
Dofetilide-induced long QT and torsades de pointes.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20070701
-
Using pharmacokinetic/pharmacodynamic modelling in safety pharmacology to better define safety margins: a regional workshop of the Safety Pharmacology Society.
Expert opinion on drug safety 20070701
-
Fluorescently labeled analogues of dofetilide as high-affinity fluorescence polarization ligands for the human ether-a-go-go-related gene (hERG) channel.
Journal of medicinal chemistry 20070628
-
Chronic arsenic exposure and cardiac repolarization abnormalities with QT interval prolongation in a population-based study.
Environmental health perspectives 20070501
-
The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents.
Bioorganic & medicinal chemistry letters 20070415
-
The pharmacological response of ischemia-related atrial fibrillation in dogs: evidence for substrate-specific efficacy.
Cardiovascular research 20070401
-
Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits.
Clinical and experimental pharmacology & physiology 20070401
-
Inhibitory effects of coronary vasodilator papaverine on heterologously-expressed HERG currents in Xenopus oocytes.
Acta pharmacologica Sinica 20070401
-
In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231.
Journal of cardiovascular pharmacology 20070401
-
A novel, non-substrate-based series of glycine type 1 transporter inhibitors derived from high-throughput screening.
Bioorganic & medicinal chemistry letters 20070315
-
Management of dofetilide overdose in a patient with known cocaine abuse.
Pharmacotherapy 20070301
-
Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function.
Journal of cardiovascular pharmacology and therapeutics 20070301
-
Simulation of developmental changes in action potentials with ventricular cell models.
Systems and synthetic biology 20070301
-
HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function.
The Journal of biological chemistry 20070223
-
Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation.
Cardiovascular research 20070201
-
L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation.
Journal of cardiovascular electrophysiology 20070201
-
Adjunctive antiarrhythmic drug therapy in patients with implantable cardioverter defibrillators: a systematic review.
European heart journal 20070201
-
Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation.
Journal of cardiovascular electrophysiology 20070201
-
Anti-arrhythmic effects of I (Na), I (Kr), and combined I (Kr)-I (CaL) blockade in an experimental model of acute stretch-related atrial fibrillation.
Cardiovascular drugs and therapy 20070201
-
A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.
Journal of pharmacological and toxicological methods 20070101
-
Pharmacological and biophysical isolation of K+ currents encoded by ether-à-go-go-related genes in murine hepatic portal vein smooth muscle cells.
American journal of physiology. Cell physiology 20070101
-
The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents.
Cardiology 20070101
-
Dofetilide: a new class III antiarrhythmic agent.
Expert review of cardiovascular therapy 20070101
-
Validation and clinical application of time-frequency analysis of atrial fibrillation electrocardiograms.
Journal of cardiovascular electrophysiology 20070101
-
Atrial fibrillation and revascularization procedures: clinical and prognostic significance. Incidence, predictors, treatment, and long-term outcome.
Indian pacing and electrophysiology journal 20070101
-
Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro.
Journal of pharmacological and toxicological methods 20070101
-
Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization.
Journal of pharmacological and toxicological methods 20070101
-
Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs.
Journal of pharmacological and toxicological methods 20070101
-
Phospholipid lysophosphatidylcholine as a metabolic trigger and HERG as an ionic pathway for extracellular K accumulation and 'short QT syndrome' in acute myocardial ischemia.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
-
[New antiarrhythmic agents in atrial fibrillation].
Archivos de cardiologia de Mexico 20070101
-
New proposals for testing drugs with IKr-blocking activity to determine their teratogenic potential.
Current pharmaceutical design 20070101
-
A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response.
PloS one 20070101
-
Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature.
BMC biotechnology 20070101
-
A call for international harmonization in therapeutic risk management.
Pharmacoepidemiology and drug safety 20061201
-
No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block.
British journal of pharmacology 20061201
-
Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels.
Clinical and experimental pharmacology & physiology 20061101
-
Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block.
Heart rhythm 20061101
-
Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide.
FEBS letters 20060918
-
Use of a failing rabbit heart as a model to predict torsadogenicity.
Toxicological sciences : an official journal of the Society of Toxicology 20060901
-
Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc.
Bioorganic & medicinal chemistry letters 20060901
-
Atrial fibrillation: choosing an antiarrhythmic drug.
Current cardiology reports 20060901
-
Frequency of high-risk use of QT-prolonging medications.
Pharmacoepidemiology and drug safety 20060601
-
RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents.
Cardiovascular research 20060601
-
Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles.
British journal of pharmacology 20060601
-
Importance of extracardiac alpha1-adrenoceptor stimulation in assisting dofetilide to induce torsade de pointes in rabbit hearts.
European journal of pharmacology 20060510
-
Molecular determinants of HERG channel block.
Molecular pharmacology 20060501
-
Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs.
Anesthesiology 20060501
-
The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers.
Journal of cardiovascular electrophysiology 20060501
-
Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials.
Archives of internal medicine 20060410
-
Effects of dofetilide and EGIS-7229, an antiarrhythmic agent possessing class III, IV, and IB activities, on myocardial refractoriness in hyperkalemia, hypokalemia, and during beta-adrenergic activation in the rabbit papillary muscle in vitro.
Journal of pharmacological sciences 20060401
-
An evaluation of the impact of oral magnesium lactate on the corrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20060401
-
Combined use of 1C and III agents for highly symptomatic, refractory atrial fibrillation.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20060401
-
Class III effects of dofetilide and arrhythmias are modulated by [K+]o in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium.
European journal of pharmacology 20060227
-
Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.
Assay and drug development technologies 20060201
-
Application of cryopreserved cells to HERG screening using a non-radioactive Rb+ efflux assay.
Assay and drug development technologies 20060201
-
Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes.
Circulation 20060124
-
Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs.
Journal of pharmacological and toxicological methods 20060101
-
Assessment of drug-induced QT interval prolongation in conscious rabbits.
Journal of pharmacological and toxicological methods 20060101
-
The reliability of echocardiographic left ventricular wall motion index to identify high-risk patients for multicenter studies.
Echocardiography (Mount Kisco, N.Y.) 20060101
-
Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval.
Journal of pharmacological and toxicological methods 20060101
-
Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs.
Journal of pharmacological and toxicological methods 20060101
-
What is drug-induced long QT and what is a potential clinical consequence?
Progress in cardiovascular nursing 20060101
-
Update of the clinical impact and issues surrounding Dofetilide (Tikosyn) therapy.
AACN advanced critical care 20060101
-
Pharmacological treatment of atrial fibrillation: mechanisms of action and efficacy of class III drugs.
Current medicinal chemistry 20060101
-
Effects of sex hormones on ECG parameters and expression of cardiac ion channels in dogs.
Acta physiologica (Oxford, England) 20060101
-
A comparative study on the cost of new antibiotics and drugs of other therapeutic categories.
PloS one 20060101
-
Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality.
Therapeutics and clinical risk management 20051201
-
QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome.
British journal of pharmacology 20051101
-
Statistical analysis of the DIAMOND MI study by the multipole method.
Physiological measurement 20051001
-
Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle.
Circulation 20050906
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Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity.
Molecular pharmacology 20050901
-
Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.
Journal of cardiovascular pharmacology and therapeutics 20050901
-
Electrophysiological effects of azimilide in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium.
European journal of pharmacology 20050822
-
Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes.
Journal of cardiovascular electrophysiology 20050801
-
Atypical proarrhythmia with dofetilide: monomorphic VT and exercise-induced torsade de pointes.
Pacing and clinical electrophysiology : PACE 20050801
-
Pharmacologic control of ventricular rate: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery.
Chest 20050801
-
Propagation of population pharmacokinetic information using a Bayesian approach: comparison with meta-analysis.
Journal of pharmacokinetics and pharmacodynamics 20050801
-
[Long QT syndrome].
Nihon rinsho. Japanese journal of clinical medicine 20050701
-
Enhancing electrical cardioversion and preventing immediate reinitiation of hemodynamically deleterious atrial fibrillation with class III drug pretreatment.
Journal of cardiovascular electrophysiology 20050701
-
A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data.
Clinical pharmacology and therapeutics 20050601
-
Antiadrenergic therapy in the control of atrial fibrillation.
Journal of cardiovascular pharmacology and therapeutics 20050601
-
Expert Canadian consensus suggestions on the rational, clinical use of ziprasidone in the treatment of schizophrenia and related psychotic disorders.
Neuropsychiatric disease and treatment 20050601
-
Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs.
European journal of pharmacology 20050404
-
[Safety of new anti-arrhythmic drugs].
Archives des maladies du coeur et des vaisseaux 20050401
-
Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel.
Molecular pharmacology 20050301
-
The influence of extracellular acidosis on the effect of IKr blockers.
Journal of cardiovascular pharmacology and therapeutics 20050301
-
Greater than the sum of its parts: combining models for useful ADMET prediction.
Journal of medicinal chemistry 20050224
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Paradoxical effect of dofetilide on action potential duration and calcium transient amplitude in newborn rabbit ventricular myocytes.
Journal of cardiovascular pharmacology 20050201
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pH-mediated acid stacking with reverse pressure for the analysis of cationic pharmaceuticals in capillary electrophoresis.
Electrophoresis 20050201
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Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity.
Cardiovascular research 20050101
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[Atrial fibrillation: choice of the method of pharmacological cardioversion].
Kardiologiia 20050101
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A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs.
Journal of pharmacological and toxicological methods 20050101
-
Choice of cardiac tissue plays an important role in the evaluation of drug-induced prolongation of the QT interval in vitro in rabbit.
Journal of pharmacological and toxicological methods 20050101
-
Antiarrhythmic drugs in patients with implantable cardioverter-defibrillators.
American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101
-
Atrial fibrillation post-myocardial infarction: frequency, consequences, and management.
Current heart failure reports 20041201
-
A benefit-risk assessment of class III antiarrhythmic agents.
Expert opinion on drug safety 20041101
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Role of a KCNH2 polymorphism (R1047 L) in dofetilide-induced Torsades de Pointes.
Journal of molecular and cellular cardiology 20041101
-
Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
Journal of cardiovascular electrophysiology 20041101
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[New anti-arrhythmics--hope or disappointment?].
Archives des maladies du coeur et des vaisseaux 20041101
-
'Early' class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat.
Circulation 20040928
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Evaluation of KCB-328, a new IKr blocking antiarrhythmic agent in pacing induced canine atrial fibrillation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20040901
-
Antiarrhythmic and proarrhythmic properties of QT-prolonging antianginal drugs.
Journal of cardiovascular pharmacology and therapeutics 20040901
-
Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.
British journal of pharmacology 20040801
-
Structural determinants of HERG channel block by clofilium and ibutilide.
Molecular pharmacology 20040801
-
[Perspectives and limitations in the treatment of vagus-induced atrial fibrillation. Insights from cellular pharmacology].
Medizinische Klinik (Munich, Germany : 1983) 20040715
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Torsade de pointes: the clinical considerations.
International journal of cardiology 20040701
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Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs.
Medical science monitor : international medical journal of experimental and clinical research 20040701
-
Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels.
Journal of pharmacological sciences 20040701
-
Comparison of kinetic properties of quinidine and dofetilide block of HERG channels.
European journal of pharmacology 20040616
-
Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels.
Basic & clinical pharmacology & toxicology 20040501
-
Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.
Acta pharmacologica Sinica 20040501
-
Pro- and antiarrhythmic effects of fast cardiac pacing in a canine model of acquired long QT syndrome.
Naunyn-Schmiedeberg's archives of pharmacology 20040401
-
Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study.
Circulation 20040330
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Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure.
Journal of the American College of Cardiology 20040303
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Cardiac ion channel effects of tolterodine.
The Journal of pharmacology and experimental therapeutics 20040301
-
Ventricular arrhythmias triggered by alerting stimuli in conscious rabbits pre-treated with dofetilide.
Basic research in cardiology 20040301
-
In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions.
Cardiovascular research 20040301
-
Dofetilide effects on the inhibition by trains of subthreshold conditioning stimuli.
Pacing and clinical electrophysiology : PACE 20040301
-
The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block.
Journal of cardiovascular pharmacology 20040301
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Antiarrhythmic drug therapy of atrial fibrillation.
Cardiology clinics 20040201
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[Pathophysiology and clinical management of atrial flatter].
Orvosi hetilap 20040125
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Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.
Bioorganic & medicinal chemistry letters 20040105
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Oral class III antiarrhythmics: what is new?
Current opinion in cardiology 20040101
-
Trials of new antiarrhythmic drugs for maintenance of sinus rhythm in patients with atrial fibrillation.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20040101
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Theoretical possibilities for the development of novel antiarrhythmic drugs.
Current medicinal chemistry 20040101
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QT and JT dispersion in the drug-induced long QT syndrome in anaesthetized rabbits is accurately detected by a three-lead surface ECG measurement.
Journal of pharmacological and toxicological methods 20040101
-
HERG K channel conductance promotes H2O2-induced apoptosis in HEK293 cells: cellular mechanisms.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101
-
Phase IV trial evaluating the effectiveness and safety of dofetilide.
The Annals of pharmacotherapy 20040101
-
Clinical review: clinical management of atrial fibrillation - rate control versus rhythm control.
Critical care (London, England) 20040101
-
Recent developments in cardiovascular drug therapy: treatment of atrial arrhythmias with new class III drugs and beyond.
Current medicinal chemistry. Cardiovascular and hematological agents 20040101
-
The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.
Journal of pharmacological and toxicological methods 20040101
-
Atrial fibrillation in the heart failure population.
The Journal of cardiovascular nursing 20040101
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Pharmacological cardioversion of atrial fibrillation: current management and treatment options.
Drugs 20040101
-
Minimally invasive atrial fibrillation ablation combined with a new technique for thoracoscopic stapling of the left atrial appendage: case report.
The heart surgery forum 20040101
-
Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiography.
Annals of internal medicine 20031216
-
The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201
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Atrial stunning: basics and clinical considerations.
International journal of cardiology 20031201
-
Introduction--roundtable on atrial fibrillation: update on mechanisms and approaches to treatment.
Journal of cardiovascular electrophysiology 20031201
-
Clinical experience with dofetilide in the treatment of patients with atrial fibrillation.
Journal of cardiovascular electrophysiology 20031201
-
Initiation and monitoring of class III antiarrhythmic agents.
Journal of cardiovascular electrophysiology 20031201
-
Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.
British journal of cancer 20031117
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Electrophysiological safety of sertindole in dogs with normal and remodeled hearts.
The Journal of pharmacology and experimental therapeutics 20031101
-
Differential recovery of action potential duration and HERG currents from the effects of two methanesulfonamide class III antiarrhythmic agents, KCB-328 and dofetilide.
Journal of cardiovascular pharmacology 20031101
-
Evaluation of the dofetilide risk-management program.
American heart journal 20031101
-
Atrial effects of the novel K(+)-channel-blocker AVE0118 in anesthetized pigs.
Cardiovascular research 20031101
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The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes.
Naunyn-Schmiedeberg's archives of pharmacology 20031001
-
A review of clinical trials assessing the efficacy and safety of newer antiarrhythmic drugs in atrial fibrillation.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20031001
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New antiarrhythmic agents for atrial fibrillation and atrial flutter: United States drug market response as an indicator of acceptance.
Pharmacotherapy 20031001
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[Progress in the clinical use of anti-arrhythmic drugs (I)].
Zhonghua er ke za zhi = Chinese journal of pediatrics 20031001
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IKr channel blockers: novel antiarrhythmic agents.
Current medicinal chemistry. Cardiovascular and hematological agents 20031001
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Blockers of the slowly delayed rectifier potassium IKs channel: potential antiarrhythmic agents.
Current medicinal chemistry. Cardiovascular and hematological agents 20031001
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Pure class III agents for prevention of sudden cardiac death.
Journal of cardiovascular electrophysiology 20030901
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Does conversion and prevention of atrial fibrillation enhance survival in patients with left ventricular dysfunction? Evidence from the Danish Investigations of Arrhythmia and Mortality ON Dofetilide/(DIAMOND) study.
Cardiac electrophysiology review 20030901
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Role of dofetilide in patients with atrial fibrillation. Insights from the Symptomatic Atrial Fibrillation Investigative Research on Dofetilide (SAFIRE-D) study.
Cardiac electrophysiology review 20030901
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Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Bioorganic & medicinal chemistry letters 20030818
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Beta-adrenoceptor activation plays a role in the reverse rate-dependency of effective refractory period lengthening by dofetilide in the guinea-pig atrium, in vitro.
British journal of pharmacology 20030802
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Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia.
Cardiovascular research 20030801
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Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog.
Cardiovascular research 20030801
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Modulation of ventricular fibrillation in isolated perfused heart by dofetilide.
Journal of cardiovascular pharmacology 20030601
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Dofetilide: a new drug to control cardiac arrhythmia.
Expert opinion on pharmacotherapy 20030601
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[Effects of clinically available drugs on the repolarization process of the heart assessed by the in vivo canine models].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030601
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Block of HERG-carried K+ currents by the new repolarization delaying agent H 345/52.
Journal of cardiovascular electrophysiology 20030601
-
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.
Bioorganic & medicinal chemistry letters 20030519
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Differences in electrophysiological and contractile properties of mammalian cardiac tissues bathed in bicarbonate - and HEPES-buffered solutions.
Acta physiologica Scandinavica 20030501
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The prognostic value of QTc interval and QT dispersion following myocardial infarction in patients treated with or without dofetilide.
Clinical cardiology 20030501
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Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems.
European journal of pharmacology 20030411
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Old and new antiarrhythmic drugs for converting and maintaining sinus rhythm in atrial fibrillation: comparative efficacy and results of trials.
The American journal of cardiology 20030320
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Pharmacologic and nonpharmacologic options to maintain sinus rhythm: guideline-based and new approaches.
The American journal of cardiology 20030320
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Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues.
The American journal of cardiology 20030320
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Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: insights into the mechanism of the superior efficacy of amiodarone.
Circulation 20030318
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Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.
Cardiovascular research 20030301
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Detection of proarrhythmia in the female rabbit heart: blinded validation.
Journal of cardiovascular electrophysiology 20030301
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Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels.
Cardiovascular research 20030201
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Dofetilide and atrial fibrillation.
The American journal of nursing 20030201
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Survival after withdrawal of dofetilide in patients with congestive heart failure and a short baseline QTc interval; a follow-up on the Diamond-CHF QT substudy.
European heart journal 20030201
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Management of arrhythmias in heart failure.
Congestive heart failure (Greenwich, Conn.) 20030101
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Potentially significant drug interactions of class III antiarrhythmic drugs.
Drug safety 20030101
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Effect of HERG-like potassium channel blocker on the carotid body chemoreception.
Advances in experimental medicine and biology 20030101
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Prevalence, prognostic significance, and treatment of atrial fibrillation in congestive heart failure with particular reference to the DIAMOND-CHF study.
Congestive heart failure (Greenwich, Conn.) 20030101
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[Development of original Russian antiarrhythmic drugs of the 3rd class].
Vestnik Rossiiskoi akademii meditsinskikh nauk 20030101
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Role of atrial fibrillation threshold evaluation on guiding treatment.
Indian pacing and electrophysiology journal 20030101
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Preventing sudden death and the use of prophylactic implanted defibrillators.
Indian pacing and electrophysiology journal 20030101
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Atrial remodeling: evolving concepts.
Indian pacing and electrophysiology journal 20030101
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Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20021201
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Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide.
Naunyn-Schmiedeberg's archives of pharmacology 20021101
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Combined endpoints: can we use them?
Statistics in medicine 20021015
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Testosterone diminishes the proarrhythmic effects of dofetilide in normal female rabbits.
Circulation 20021015
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Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations.
European journal of pharmacology 20021004
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Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve.
British journal of pharmacology 20021001
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Pfizer allows community pharmacies to dispense dofetilide.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020915
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Maintaining stability of sinus rhythm in atrial fibrillation: antiarrhythmic drugs versus ablation.
Current cardiology reports 20020901
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QT interval dynamics predict mortality in high-risk patients after myocardial infarction.
Scandinavian cardiovascular journal : SCJ 20020901
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Practitioner acceptance of the dofetilide risk-management program.
Pharmacotherapy 20020801
-
The functional properties of the human ether-à-go-go-like (HELK2) K+ channel.
The European journal of neuroscience 20020801
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How to enhance acute outcome of electrical cardioversion by drug therapy: importance of immediate reinitiation of atrial fibrillation.
Journal of cardiovascular electrophysiology 20020801
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[Synthesis and vasorelaxant activities of benzopyran-4-one hydrazone derivatives].
Yao xue xue bao = Acta pharmaceutica Sinica 20020801
-
New p-methylsulfonamido phenylethylamine analogues as class III antiarrhythmic agents: design, synthesis, biological assay, and 3D-QSAR analysis.
Journal of medicinal chemistry 20020704
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Transient atrial mechanical dysfunction (stunning) after cardioversion of atrial fibrillation and flutter.
American heart journal 20020701
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Prevention of and medical therapy for atrial arrhythmias in heart failure.
Heart failure reviews 20020701
-
Significance and control of cardiac arrhythmias in patients with congestive cardiac failure.
Heart failure reviews 20020701
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A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia.
European journal of clinical pharmacology 20020601
-
[Atrial fibrillation in heart failure].
Herz 20020601
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Effects of dofetilide on cardiovascular tissues from normo- and hypertensive rats.
The Journal of pharmacy and pharmacology 20020501
-
Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line.
Chinese medical journal 20020501
-
Evaluation of Pulsincap to provide regional delivery of dofetilide to the human GI tract.
International journal of pharmaceutics 20020402
-
A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?
The Journal of physiology 20020401
-
Electrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patterns.
Circulation 20020305
-
Effects of the I(Kr)-blocking agent dofetilide and of the I(Ks)-blocking agent chromanol 293b on regional disparity of left ventricular repolarization in the intact canine heart.
Journal of cardiovascular pharmacology 20020301
-
Antidysrhythmic agents at the turn of the twenty-first century: a current review.
Critical care nursing clinics of North America 20020301
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Effect of dofetilide on QT dispersion and the prognostic implications of changes in QT dispersion for patients with congestive heart failure.
European journal of heart failure 20020301
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Sex, hormones, and repolarization.
Cardiovascular research 20020215
-
Dofetilide block involves interactions with open and inactivated states of HERG channels.
Pflugers Archiv : European journal of physiology 20020201
-
New antiarrhythmic drugs for the treatment of atrial fibrillation.
Pacing and clinical electrophysiology : PACE 20020201
-
Management of arrhythmias in heart failure.
Cardiology in review 20020101
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Pharmacodynamic effect of continuous vs intermittent dosing of dofetilide on QT interval.
British journal of clinical pharmacology 20020101
-
Vascular effects of class-III antiarrhythmic drugs: chromanol 293B, but not dofetilide blocks the smooth muscle delayed rectifier K+ channel.
Basic research in cardiology 20020101
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A benefit-risk assessment of class III antiarrhythmic agents.
Drug safety 20020101
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Tachycardiomyopathy.
Indian pacing and electrophysiology journal 20020101
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Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels.
Molecular pharmacology 20011201
-
A review of class III antiarrhythmic agents for atrial fibrillation: maintenance of normal sinus rhythm.
Pharmacotherapy 20011201
-
Effects of the class III antiarrhythmic agent dofetilide (UK-68,798) on L-type calcium current from rabbit ventricular myocytes.
The Journal of pharmacy and pharmacology 20011201
-
Dofetilide: what role in the treatment of ventricular tachyarrhythmias?
European heart journal 20011201
-
A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained ventricular tachycardia and ischaemic heart disease.
European heart journal 20011201
-
Effects of intravenous dofetilide on induction of atrioventricular re-entrant tachycardia.
Heart (British Cardiac Society) 20011101
-
Drug block of I(kr): model systems and relevance to human arrhythmias.
Journal of cardiovascular pharmacology 20011101
-
Transient kinetic and dynamic interactions between verapamil and dofetilide, a class III antiarrhythmic.
Journal of clinical pharmacology 20011101
-
Practical approach to the use and monitoring of dofetilide therapy.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011101
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[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
European journal of pharmacology 20011026
-
Development and evaluation of high throughput functional assay methods for HERG potassium channel.
Journal of biomolecular screening 20011001
-
Is it rational, reasonable or excessive, and consistently applied? One view of the increasing FDA emphasis on safety first for the release and use of antiarrhythmic drugs for supraventricular arrhythmias.
Journal of cardiovascular pharmacology and therapeutics 20011001
-
Pericardioversion dofetilide does not suppress immediate and subacute recurrences of persistent atrial fibrillation.
Circulation 20010911
-
Efficacy of azimilide and dofetilide in the dog right atrial enlargement model of atrial flutter.
Journal of cardiovascular electrophysiology 20010901
-
A randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of intravenously administered dofetilide in patients with Wolff-Parkinson-White syndrome.
Pacing and clinical electrophysiology : PACE 20010801
-
Efficacy of dofetilide in the treatment of atrial fibrillation-flutter in patients with reduced left ventricular function: a Danish investigations of arrhythmia and mortality on dofetilide (diamond) substudy.
Circulation 20010717
-
What niche will newer class III antiarrhythmic drugs occupy?
Current cardiology reports 20010701
-
Efficacy and safety of dofetilide in the prevention of symptomatic episodes of paroxysmal supraventricular tachycardia: a 6-month double-blind comparison with propafenone and placebo.
American heart journal 20010701
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'Use-dependent' effects of cisapride on postrest action potentials in rabbit ventricular myocardium.
European journal of pharmacology 20010622
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Three things you should know when considering the atria: location, location, location.
Circulation research 20010608
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Potential ionic mechanism for repolarization differences between canine right and left atrium.
Circulation research 20010608
-
Class III antiarrhythmics and phenytoin: teratogenicity due to embryonic cardiac dysrhythmia and reoxygenation damage.
Current pharmaceutical design 20010601
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Cardiac and hemodynamic effects of intravenous dofetilide in patients with heart failure.
The American journal of cardiology 20010601
-
Impact of sex and gonadal steroids on prolongation of ventricular repolarization and arrhythmias induced by I(K)-blocking drugs.
Circulation 20010501
-
Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part II: Pharmacological profile.
Cardiovascular research 20010501
-
Role of antiarrhythmic therapy in patients at risk for sudden cardiac death: an evidence-based review.
Pharmacotherapy 20010501
-
Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model.
Journal of cardiovascular electrophysiology 20010501
-
Comparison of the rate dependent effects of dofetilide and ibutilide in the newborn heart.
Pacing and clinical electrophysiology : PACE 20010501
-
Mechanisms of antiarrhythmic drug action on termination of atrial flutter.
Pacing and clinical electrophysiology : PACE 20010501
-
Tedisamil and dofetilide-induced torsades de pointes, rate and potassium dependence.
British journal of pharmacology 20010401
-
The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF.
Cardiovascular research 20010401
-
Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade.
The Journal of physiology 20010401
-
Dofetilide (Tikosyn): a new drug to control atrial fibrillation.
Cleveland Clinic journal of medicine 20010401
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Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy.
Journal of cardiovascular pharmacology and therapeutics 20010401
-
Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits.
Circulation 20010320
-
Pause-dependent polymorphic ventricular tachycardia during long-term treatment with dofetilide: a placebo-controlled, implantable cardioverter-defibrillator-based evaluation.
Journal of the American College of Cardiology 20010315
-
Dofetilide: is the treatment worse than the disease?
Journal of the American College of Cardiology 20010315
-
Qtc interval as a guide to select those patients with congestive heart failure and reduced left ventricular systolic function who will benefit from antiarrhythmic treatment with dofetilide.
Circulation 20010313
-
[Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter].
Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20010301
-
Myocardial repolarization and drugs. Impossibility to predict the dominance of anti-arrhythmic over pro-arrhythmic effects of drugs due to differential and ventricular electrical remodeling.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20010301
-
Qt dispersion has no prognostic information for patients with advanced congestive heart failure and reduced left ventricular systolic function.
Circulation 20010213
-
[3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel?
European journal of pharmacology 20010202
-
Pharmacologic management of atrial fibrillation: current therapeutic strategies.
American heart journal 20010201
-
Differential effects of dofetilide, amiodarone, and class lc drugs on left and right atrial refractoriness and left atrial vulnerability in pigs.
Naunyn-Schmiedeberg's archives of pharmacology 20010201
-
Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias.
European journal of pharmacology 20010119
-
Effect of dofetilide on the pharmacokinetics of digoxin.
The American journal of cardiology 20010115
-
Intravenous antiarrhythmic agents.
Current opinion in cardiology 20010101
-
Effects of EGIS-7229 (S 21407), a novel class III antiarrhythmic drug, on myocardial refractoriness to electrical stimulation in vivo and in vitro.
Journal of cardiovascular pharmacology 20010101
-
Dofetilide: a new class III antiarrhythmic agent.
The Canadian journal of cardiology 20010101
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pH-mediated field-amplified sample stacking of pharmaceutical cations in high-ionic strength samples.
Electrophoresis 20010101
-
Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibers.
Journal of cardiovascular electrophysiology 20010101
-
How to manage atrial fibrillation: an update on recent clinical trials.
Cardiology in review 20010101
-
Dofetilide: a new class III antiarrhythmic for the management of atrial fibrillation.
Progress in cardiovascular nursing 20010101
-
Newer antiarrhythmic drugs.
Indian heart journal 20010101
-
New antiarrhythmic agents for atrial fibrillation.
Current opinion in investigational drugs (London, England : 2000) 20010101
-
KCB-328 (C&C Research Labs).
Current opinion in investigational drugs (London, England : 2000) 20010101
-
Current management of symptomatic atrial fibrillation.
Drugs 20010101
-
Pharmacologic conversion of atrial fibrillation: a systematic review of available evidence.
Progress in cardiovascular diseases 20010101
-
Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017.
Acta pharmacologica Sinica 20010101
-
Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells.
Molecular pharmacology 20001101
-
Dofetilide: A new antiarrhythmic agent approved for conversion and/or maintenance of atrial fibrillation/atrial flutter.
Drugs of today (Barcelona, Spain : 1998) 20001101
-
Positive atrial inotropic effect of dofetilide after cardioversion of atrial fibrillation or flutter.
The American journal of cardiology 20000915
-
Dofetilide, a new class III antiarrhythmic agent.
Pharmacotherapy 20000701
-
Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation.
FEBS letters 20000526
-
Dofetilide: a review of its use in atrial fibrillation and atrial flutter.
Drugs 19991201
-
Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group.
The New England journal of medicine 19990916
-
Dynamic analysis of dofetilide-induced changes in ventricular repolarization.
Clinical pharmacology and therapeutics 19980901
-
A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.
FEBS letters 19971103
-
Electrophysiologic profile and efficacy of intravenous dofetilide (UK-68,798), a new class III antiarrhythmic drug, in patients with sustained monomorphic ventricular tachycardia. Dofetilide Arrhythmia Study Group.
The American journal of cardiology 19951115
