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Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors.
The Journal of pharmacy and pharmacology 20120801
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DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
Bioorganic & medicinal chemistry 20120715
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Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120715
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Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents.
DNA repair 20120102
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Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.
Cell death & disease 20120101
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Bioactivation pathways of the cannabinoid receptor 1 antagonist rimonabant.
Drug metabolism and disposition: the biological fate of chemicals 20111001
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Disproportionation of O-methylhydroxylamine catalyzed by aquapentacyanoferrate(II).
Inorganic chemistry 20110919
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DNA repair BER pathway inhibition increases cell death caused by oxidative DNA damage in Trypanosoma cruzi.
Journal of cellular biochemistry 20110801
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N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
Neuro-oncology 20110501
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Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110401
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Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair.
Cancer research 20110315
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Diphenylthiourea, a common rubber chemical, is bioactivated to potent skin sensitizers.
Chemical research in toxicology 20110114
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Accumulation of true single strand breaks and AP sites in base excision repair deficient cells.
Mutation research 20101210
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Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia.
Leukemia 20101001
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Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions.
DNA repair 20091102
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Nucleophile addition of reduced glutathione on 2-methyl-2-nitroso compound: a combined electron paramagnetic resonance spectroscopy and electrospray tandem mass spectrometry study.
Journal of the American Society for Mass Spectrometry 20091101
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Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair.
Nuclear medicine and biology 20091101
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Inhibitory properties of trapping agents: glutathione, potassium cyanide, and methoxylamine, against major human cytochrome p450 isoforms.
Drug metabolism letters 20090401
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Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 20090315
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Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.
Autonomic & autacoid pharmacology 20090101
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The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine.
Journal of cellular biochemistry 20080901
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[Effects of manumycin combined with methoxyamine on apoptosis in myeloid leukemia U937 cells].
Ai zheng = Aizheng = Chinese journal of cancer 20080801
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Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance.
Molecular pharmacology 20080701
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Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst.
Chemical communications (Cambridge, England) 20070421
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Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain.
Blood 20070301
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Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha.
Clinical cancer research : an official journal of the American Association for Cancer Research 20070301
-
Role for DNA polymerase beta in response to ionizing radiation.
DNA repair 20070204
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Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.
Clinical cancer research : an official journal of the American Association for Cancer Research 20070101
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The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target.
Molecular aspects of medicine 20070101
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A stronger DNA damage-induced G2 checkpoint due to over-activated CHK1 in the absence of PARP-1.
Cell cycle (Georgetown, Tex.) 20061001
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Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization.
International journal of radiation oncology, biology, physics 20060801
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Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence.
Molecular cancer therapeutics 20060401
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Improved measurement of dibenzo[a,l]pyrene-induced abasic sites by the aldehyde-reactive probe assay.
Mutation research 20051230
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DNA repair inhibition: a selective tumour targeting strategy.
Trends in molecular medicine 20051101
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Development and validation of an HPLC-UV method for the analysis of methoxyamine using 4-(diethylamino)benzaldehyde as a derivatizing agent.
Journal of pharmaceutical and biomedical analysis 20050915
-
Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705
-
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells.
Leukemia 20050401
-
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Molecular cancer therapeutics 20040801
-
Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway.
Current opinion in investigational drugs (London, England : 2000) 20040601
-
Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031005
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Role of MutSalpha in the recognition of iododeoxyuridine in DNA.
Cancer research 20030901
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Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization.
Cancer research 20030215
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A new sensitive HPLC assay for methoxyamine and its analogs.
Journal of pharmaceutical and biomedical analysis 20021015
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Base excision repair as a therapeutic target in colon cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20020901
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Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage.
DNA repair 20020429
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[Biochemical diagnosis of pheochromocytoma and neuroblastomas].
Annales de biologie clinique 20020101
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[Normal values of plasma methoxyamines in the setting of renal insufficiency and peri-operative stress. Consequences for the etiological diagnosis of hypertension].
Annales d'endocrinologie 20011101
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DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage.
Cancer research 20011015
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Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity.
Biochemistry 20010626
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Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.
Mutation research 20010510
