I-BET726 Synthesis Route

I-BET726 Synthesis

I-BET726 (Synonyms: 4-[(2S,4R)-1-Acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]benzoic acid)

I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins.1,2 It exhibits >1,000-fold selectivity for these proteins over other bromodomain-containing homologs.2 I-BET726 inhibits cell growth and induces cytotoxicity in neuroblastoma cell lines by modulating the expression of genes involved in apoptosis and Myc signaling.2 I-BET726 can be administered orally to animals, and it reduces tumor growth in mouse xenograft models of human neuroblastoma.2

I-BET726

A selective inhibitor of BET family proteins

Item No. AA38544
CAS No. 1300031-52-0
Purity: 95%

1mg

＄27.00

2mg

＄37.00

5mg

＄58.00

10mg

＄88.00

50mg

＄252.00

100mg

＄411.00

250mg

＄808.00

＄2,317.00

Quantity

Add to Cart

Buy Now

I-BET726 Synthetic Route

AB51410

CAS: 106-40-1

AB43356

CAS: 95-14-7

AB45505

CAS: 75-07-0

CAS: 1300031-83-7

AA45848

CAS: 13162-05-5

AY18891

CAS: 2091562-05-7

AB45510

CAS: 75-36-5

CAS: 1300031-80-4

AB46513

CAS: 99768-12-4

CAS: 1300031-74-6

AB72588

CAS: 2743-38-6

CAS: 1304126-68-8

CAS: 1300031-74-6

AB66978

CAS: 106-39-8

BF33208

CAS: 1300031-70-2

AA38544

CAS: 1300031-52-0

1.1: toluene / 12 h / 20 °C / Inert atmosphere
2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere
2.2: 2 h / -5 °C
3.1: pyridine / dichloromethane / 2 h / 0 °C
4.1: tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 0.17 h / 20 °C
4.2: 16 h / Reflux
5.1: hydrogenchloride / methanol; water / 2 h / Reflux
6.1: L-Lactic acid / ethanol; water / 0.5 h / Reflux
6.2: 0.5 h / Reflux
7.1: sodium carbonate / dichloromethane; water
8.1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; DavePhos / toluene / 19 h / 80 °C / Reflux
9.1: sodium hydroxide; water / ethanol / 1 h / Reflux

Order I-BET726 Intermediates

{{item['cas']}} | {{item['name']}}

MF:{{item['mf']}} MW:{{item['mw']}}

Download SDS

Catalog No.

Pack Size

Purity

Availability

Price

${{getUSMoneyFormat(sku['price'])}}

Add to Cart

Buy Now

References

1.Current Patent Assignee: GLAXOSMITHKLINE - EP2955524, 2015, A2. 
2.Gosmini, R., Nguyen, V.L., Toum, J., et al. The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline apoA1 up-regulator and selective BET bromodomain inhibitor. J. Med. Chem. 57, 8111-8131 (2014).

3.Wyce, A., Ganji, G., Smitheman, K.N., et al. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PLoS One 8(8), e72967 (2013).