DBCO-NHS Synthesis Route

DBCO-NHS Synthesis

DBCO-NHS (Synonyms: 11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester)

DBCO-NHS is an azido-reactive click-chemistry reagent.1 It has been conjugated to various anticancer agents for targeting azido-labeled cancer cells in mice.

DBCO-NHS

An azido-reactive click-chemistry reagent

Item No. AE66215
CAS No. 1353016-71-3
Purity: 98%

250mg

＄81.00

＄261.00

＄855.00

Quantity

Add to Cart

Buy Now

DBCO-NHS Synthetic Route

AB45313

CAS: 2222-33-5

AA08385

CAS: 1021-91-6

AX05228

CAS: 23112-88-1

AF38800

CAS: 23194-93-6

AB75873

CAS: 1490-25-1

A131868

CAS: 1353016-67-7

CAS: 1353016-68-8

CAS: 1353016-69-9

AE67930

CAS: 1353016-70-2

CAS: 6066-82-6

AE66215

CAS: 1353016-71-3

1.1: pyridine; hydroxylamine hydrochloride / ethanol / 3 h / Reflux
2.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / 20 °C
3.1: diisobutylaluminium hydride / THF / 20 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: bromine / dichloromethane / 1 h / 0 °C / Inert atmosphere
6.1: potassium tert-butylate / tetrahydrofuran / 4 h / -40 °C / Inert atmosphere
7.1: lithium hydroxide / water / 20 °C
7.2: pH 14
7.3: pH 2
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

Order DBCO-NHS Intermediates

{{item['cas']}} | {{item['name']}}

MF:{{item['mf']}} MW:{{item['mw']}}

Download SDS

Catalog No.

Pack Size

Purity

Availability

Price

${{getUSMoneyFormat(sku['price'])}}

Add to Cart

Buy Now

References

1.Angew. Chem. Int. Ed. 2011, 50, 11117 –11120. 
2.Wang, H., Wang, R., Cai, K., et al. Selective in vivo metabolic cell-labeling-mediated cancer targeting. Nat. Chem. Biol. 13(4), 415-424 (2017).