(S,R,S)-AHPC-Me hydrochloride Synthesis Route

(S,R,S)-AHPC-Me hydrochloride Synthesis

(S,R,S)-AHPC-Me hydrochloride (Synonyms: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride)

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

(S,R,S)-AHPC-Me hydrochloride

Item No. AX64028
CAS No. 1948273-03-7
Purity: 98%

100mg

＄16.00

250mg

＄27.00

＄90.00

＄300.00

Quantity

Add to Cart

Buy Now

(S,R,S)-AHPC-Me hydrochloride Synthetic Route

AB50285

CAS: 27298-97-1

AB56178

CAS: 847728-89-6

BG36647

CAS: 1973408-97-7

A168334

CAS: 1948273-01-5

AB45674

CAS: 13726-69-7

BL17309

CAS: 2313528-38-8

BL17832

CAS: 2086301-13-3

Al54018

CAS: 62965-35-9

BG36677

CAS: 1997302-16-5

AX64028

CAS: 1948273-03-7

1: triethylamine / dichloromethane / 2 h / 20 °C
2: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 2 h / 120 °C
3: hydrogenchloride / methanol / 2 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C
5: hydrogenchloride / methanol / 2 h / 20 °C
6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C
7: hydrogenchloride / methanol / 2 h / 20 °C

Order (S,R,S)-AHPC-Me hydrochloride Intermediates

{{item['cas']}} | {{item['name']}}

MF:{{item['mf']}} MW:{{item['mw']}}

Download SDS

Catalog No.

Pack Size

Purity

Availability

Price

${{getUSMoneyFormat(sku['price'])}}

Add to Cart

Buy Now

References

1.Current Patent Assignee: YALE UNIVERSITY - WO2019/195609, 2019, A2. 
2.WO/2017/030814A1
3.Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.